Despite the early description of the anatomy of the adrenal glands by Eustachio<sup>55 Orth D.N., Kovacs W.J., DeBold C.R. The adrenal cortex Williams Textbook of Endocrinology Philadelphia: WB Saunders (1992).  489

Cliccare qui per andare alla sezione Riferimenti</sup> in 1563, the function and diseases of the “glandulae renis incumbentes” remained unknown until Addison's report of three patients with anemia and adrenal disease in the mid 1800s.<sup>24 Gaunt R. History of the adrenal cortex Handbook of Physiology. Section 7, Endocrinology, vol VI, Adrenal Gland Washington, DC: American Physiological Society (1975).  1

Cliccare qui per andare alla sezione Riferimenti, 55 Orth D.N., Kovacs W.J., DeBold C.R. The adrenal cortex Williams Textbook of Endocrinology Philadelphia: WB Saunders (1992).  489

Cliccare qui per andare alla sezione Riferimenti</sup> Adrenal tumors were recognized and studied by the end of the nineteenth century.<sup>24 Gaunt R. History of the adrenal cortex Handbook of Physiology. Section 7, Endocrinology, vol VI, Adrenal Gland Washington, DC: American Physiological Society (1975).  1

Cliccare qui per andare alla sezione Riferimenti</sup> The rarity of adrenal cancer increased the difficulty of treating this disease and remains the main reason for the lack of significant advances in its treatment despite other improvements in molecular understanding and clinical detection.