%In March 1998, the American Journal of Ophthalmology featured a cluster of publications1Nussenblatt R.B., Lane H.C. Human immunodeficiency virus diseasechanging patterns of intraocular inflammation Am J Ophthalmol 1998 ;  125 : 374-382 [cross-ref]

Cliccare qui per andare alla sezione Riferimenti, 2Holland G.N. Pieces of a puzzletoward a better understanding of intraocular inflammation associated with human immunodeficiency virus disease Am J Ophthalmol 1998 ;  125 : 383-385 [cross-ref]

Cliccare qui per andare alla sezione Riferimenti, 3Zegans M.E., Walton R.C., Holland G.N., O’Donnell J.R., Jacobson M.A., Margolis T.P. Transient vitreous inflammatory reactions associated with combination antiretroviral therapy in patients with AIDS and cytomegalovirus retinitis Am J Ophthalmol 1998 ;  125 : 292-300 [cross-ref]

Cliccare qui per andare alla sezione Riferimenti that focused on the emerging problem of intraocular inflammation in patients with human immunodeficiency virus disease. Included was one of the early descriptions of “immune recovery uveitis,” a condition in which heightened intraocular inflammatory reactions, attributable to the improved immune function associated with new potent antiretroviral therapies, occurs in some patients with preexisting cytomegalovirus retinitis.3Zegans M.E., Walton R.C., Holland G.N., O’Donnell J.R., Jacobson M.A., Margolis T.P. Transient vitreous inflammatory reactions associated with combination antiretroviral therapy in patients with AIDS and cytomegalovirus retinitis Am J Ophthalmol 1998 ;  125 : 292-300 [cross-ref]

Cliccare qui per andare alla sezione Riferimenti, 4Karavellas M.P., Lowder C.Y., Macdonald J.C., Avila C.P., Freeman W.R. Immune recovery vitritis associated with inactive cytomegalovirus retinitis Arch Ophthalmol 1998 ;  116 : 169-175

Cliccare qui per andare alla sezione Riferimenti Now, 2 years later, immune recovery uveitis is believed to be the leading cause of severe, new vision loss in patients with cytomegalovirus retinitis related to the acquired immunodeficiency syndrome.5Holland G.N. Immune recovery uveitis Ocul Immunol Inflamm 1999 ;  7 : 215-221 [cross-ref]

Cliccare qui per andare alla sezione Riferimenti Nevertheless, the disorder remains poorly understood. A recently published study⁶ and two additional articles^7,8 in this issue of the journal address some of the questions that have arisen about immune recovery uveitis, and highlight many of the problems that remain to be solved.