The recommended immunization protocols for children have changed dramatically over time. In fact, none of the current vaccines were available at all or in their current make-up only a decade ago. The changes of immunizations continue at a rapid rate and within another decade, the current vaccinations likely will have been replaced. This article highlights the newly released vaccine for Lyme disease, especially how it applies to pediatric patients, and discusses a selection of potential vaccines or technologies, including vaccines for allergy and cocaine abuse, and the potential for edible plant vaccines.