The impairment and severity of schizophrenia, comparable in disability and lost human potential to other (more established) neurologic disorders, belied its earlier characterization as a psychologic malady devoid of organic causation or pathology. Although its fundamental pathobiology remains elusive, an ever-increasing array of neuroimaging technologies now provides compelling evidence of (subtle) abnormalities of cerebral structure and function in patients with schizophrenia. This article reviews the progress thus far, as the Decade of the Brain draws to a close, in understanding the nature and extent of structural brain abnormalities observed in neuroimaging studies of schizophrenia.