Since the introduction of systemic corticosteroids, clinical dermatologists have learned to modify a vast array of skin diseases by using the potent antiinflammatory and immunosuppressive properties of this class of drugs. However, glucocorticoids have proven to be the “archetypal double-edged sword of medicine.”<sup>28 Gallant C., Kenny P. Oral glucocorticoids and their complications J Am Acad Dermatol 1986 ;  14 : 161-177  [cross-ref]

Cliccare qui per andare alla sezione Riferimenti</sup> Their potential to cause multiple adverse side effects presents the dermatologist with difficult decisions on the management of patients with potentially steroid-responsive disorders. The possible beneficial effects of systemic glucocorticoids must be weighed against risk factors including their probability of occurrence and their degree of harm. In general, the risk of adverse effects of corticosteroids increases with duration of therapy and frequency of administration. Side effects such as gastrointestinal intolerance, mood changes, nervousness, and insomnia can occur with short courses of corticosteroids.