Giant papillary conjunctivitis (GPC) was first described by Spring in 1974.<sup>64 Spring T.F. Reaction to hydrophilic lenses Med J Aust 1974 ;  1 : 499-500

Cliccare qui per andare alla sezione Riferimenti</sup> He described an allergic-like reaction on the upper tarsal plate in 78 of 170 wearers of contact lenses. These patients complained of ocular irritation, mucus discharge, and excessive contact lens movement, as well as a decrease in their ability to wear contact lenses. He noted that this condition occurred on an average of 18 months after patients had been fitted with soft contact lenses.

Allansmith et al<sup>4References 4, 13, 22, 31, 32, 37, 44, 58, 61, 63, 65, and 67. Portions of this article appeared in Transactions of the American Ophthalmological Society, 1994; reprinted with permission.

Cliccare qui per andare alla sezione Riferimenti</sup> described this syndrome in detail, naming it GPC. Although GPC is predominantly associated with soft contact lens wear, it has now been reported in patients with rigid lenses, ocular prostheses, exposed sutures following ocular surgery, extruded scleral buckle, filtering blebs, band keratopathy, corneal foreign bodies, limbal dermoids, and cyanoacrylate tissue adhesives. ^{*References 4, 13, 22, 31, 32, 37, 44, 58, 61, 63, 65, and 67. Portions of this article appeared in Transactions of the American Ophthalmological Society, 1994; reprinted with permission.}