Elevated S100B level in cerebrospinal fluid could predict poor outcome of carbon monoxide poisoning - 21/11/11
, Yoshito Kamijo, MD b, Ayako Ide, MD c, Kuniko Yoshimura b, Takashi Nishikawa, PhD b, Kazui Soma, MD b, Hideki Mochizuki, MD aAbstract |
Objective |
S100B is a calcium-binding protein produced by astroglia in the brain and has been used as a marker of neuronal damage after brain trauma. We investigated the utility of S100B in cerebrospinal fluid (CSF) measured during the early phase of carbon monoxide (CO) poisoning in predicting the subsequent clinical course.
Methods |
The study included 31 patients who were admitted to the hospital with loss of consciousness following CO poisoning. S100B levels were measured by enzyme-linked immunosorbent assay in CSF, and serum samples collected simultaneously within 24 hours and on the fourth day after CO exposure. All patients were followed for at least 3 months and divided into 3 groups based on the clinical course: persistent vegetative state (PVS), delayed encephalopathy (DE), and complete recovery with no complications (NC).
Results |
During the 3-month period, 3 patients developed PVS, 5 developed DE, and 23 were classified as NC. The mean S100B levels in the CSF within 24 hours after CO exposure were higher in the PVS group (9.25 ng/mL) than in the DE (2.03 ng/mL) and NC groups (1.86 ng/mL). However, the mean serum S100B levels were not elevated in the 3 groups (0.21, 0.59, and 0.16 ng/mL, respectively).
Conclusion |
Early elevation of S100B in CSF after CO poisoning could be a suitable predictor of subsequent development of PVS.
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| ☆ | Author contributions: T.I. and Y.K. designed the study. T.I., Y.K., and A.I. treated the patients. K.Y. assisted with sample analysis, and T.I. supervised data collection. T.I. drafted the manuscript, and all authors contributed to the revisions and approved the final submission. T.I. takes responsibility for the paper as a whole. |
| ☆☆ | Funding and support: This work was supported by The Japanese Ministry of Education, Culture, Sports, Science and Technology KAKENHI 21790849: Grant-in-Aid for Young Scientists (B). |
| Conflict of interest statement: The authors declare no conflict of interest. |
Vol 30 - N° 1
P. 222-225 - gennaio 2012 Ritorno al numero
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