Mortality from nonulcer bleeding is similar to that of ulcer bleeding in high-risk patients with nonvariceal hemorrhage: a prospective database study in Italy - 15/01/12
PNED 1, PNED 2, and Prometeo Investigators
Reprint requests: Riccardo Marmo, MD, Division of Gastroenterology, Hospital “L. Curto,” Polla, Via Sottobraida 32, 84037 Sant'Arsenio, ItalyRiassunto |
Background |
Nonulcer causes of bleeding are often regarded as minor, ie, associated with a lower risk of mortality.
Objective |
To assess the risk of death from nonulcer causes of upper GI bleeding (UGIB).
Design |
Secondary analysis of prospectively collected data from 3 national databases.
Settings |
Community and teaching hospitals.
Patients |
Consecutive patients admitted for acute nonvariceal UGIB.
Interventions |
Early endoscopy, medical and endoscopic treatment as appropriate.
Main Outcome Measurements |
Thirty-day mortality, recurrent bleeding, and need for surgery.
Results |
A total of 3207 patients (65.8% male), mean (standard deviation) age 68.3 (16.4) years, were analyzed. Overall mortality was 4.45% (143 patients). According to the source of bleeding, mortality was 9.8% for neoplasia, 4.8% for Mallory-Weiss tears, 4.8% for vascular lesions, 4.4% for gastroduodenal erosions, 4.4% for duodenal ulcer, and 3.1% for gastric ulcer. Frequency of death was not different among benign endoscopic diagnoses (overall P = .567). Risk of death was significantly higher in patients with neoplasia compared with benign conditions (odds ratio 2.50; 95% CI, 1.32-4.46; P < .0001). Gastric or duodenal ulcer significantly increased the risk of death, but this was not related to the presence of high-risk stigmata (P = .368). The strongest predictor of mortality for all causes of nonvariceal UGIB was the overall physical status of the patient measured with the American Society of Anesthesiologists score (1-2 vs 3-4, P < .001).
Limitations |
No data on the American Society of Anesthesiologists class score in the Prometeo study.
Conclusions |
Nonulcer causes of nonvariceal UGIB have a risk of death, similar to bleeding peptic ulcers in the clinical context of a high-risk patient.
Il testo completo di questo articolo è disponibile in PDF.Abbreviations : ASA, IQR, SD, UGIB
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| DISCLOSURE: The authors disclosed no financial relationships relevant to this publication. |
Vol 75 - N° 2
P. 263 - febbraio 2012 Ritorno al numero
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