Primary cutaneous diffuse large B-cell lymphoma, leg type and secondary cutaneous involvement by testicular B-cell lymphoma share identical clinicopathological and immunophenotypical features - 14/03/12
Reprint requests: Octavio Servitje, MD, Department of Dermatology, Hospital Universitari de Bellvitge, C/Feixa Llarga s/n, L’ Hospitalet de Llobregat, 08907-Barcelona, Spain.Abstract |
Background |
Primary cutaneous diffuse large B-cell lymphoma (PCDLBCL), leg type can eventually disseminate to extracutaneous sites including testes. In addition, patients with testicular lymphoma can develop specific skin involvement.
Objective |
We sought to describe similarities between PCDLBCL, leg type and testicular B-cell lymphoma affecting the skin.
Methods |
We report two cases with typical clinicopathological and immunophenotypical features of leg type lymphoma occurring simultaneously with a testicular B-cell lymphoma. We also report an additional case of PCDLBCL, leg type with secondary testicular involvement.
Results |
All cases presented with typical red tumors exclusively located on the legs. Histologically, all cases showed a diffuse nonepidermotropic infiltrate composed of large blastic cells mainly centroblastic type. Phenotype showed strong positivity for Bcl-2, MUM-1, and FOXP1. Epstein-Barr virus stains and CD30 were negative in the 3 cases. In all cases the testicular infiltration showed the same pathological and phenotypical changes to those observed in the skin.
Limitations |
This was a retrospective case series study.
Conclusion |
Skin involvement by testicular B-cell lymphomas and PCDLBCL, leg type are indistinguishable on the basis of pathologic and immunophenotypical features, therefore specific investigation and clinic correlation are needed.
Il testo completo di questo articolo è disponibile in PDF.Key words : extracutaneous involvement, extracutaneous spread, primary cutaneous diffuse large B-cell lymphoma leg type, secondary cutaneous involvement, testicular involvement, testicular lymphoma
Abbreviations used : CNS, CT, EBV, PCDLBCL
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| Funding sources: None. |
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| Conflicts of interest: None declared. |
Vol 66 - N° 4
P. 650-654 - aprile 2012 Ritorno al numero
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