Optimal Surgical Margin in Nephron-sparing Surgery for T1b Renal Cell Carcinoma - 01/04/12
Reprint requests: Xin Yao, Department of Genitourinary Oncology, Tianjin Medical University Cancer Institute & Hospital, Tianjin, 300060, ChinaRiassunto |
Objective |
To determine the optimal surgical margins in nephron-sparing surgery (NSS) for T1b renal cell carcinomas (RCC).
Materials and Methods |
We retrospectively assessed 87 T1b RCC specimens after radical nephrectomy through whole-kidney continuous sections, with 92 T1a RCCs included as controls. The completeness of pseudocapsule (PS) and extra-PS lesions and multifocality were microscopically examined, as was the greatest distance between extra-PS lesions and primary tumors.
Results |
The rates of incomplete PS (34% [30/87] vs 18% [17/92], P = .015) and positive cancer lesions beyond the PS (39% [34/87] vs 25% [23/92], P = .043) were significantly higher in the T1b than in the T1a group. All extra-PS lesions were located within 3.0 mm of the primary tumor. Multifocal tumors were found in 6% (5/87) of patients with T1b and 5% (5/92) of patients with T1a tumors (P = .928).
Conclusion |
These results indicate that 4 mm may be the optimal surgical margin for NSS for patients with T1b RCC because all extra-PS lesions were located within 3 mm of the primary tumors.
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Vol 79 - N° 4
P. 836-839 - aprile 2012 Ritorno al numero
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