Ursodeoxycholic acid treatment for patients with postcholecystectomy pain and bile microlithiasis - 26/04/12
Reprint address: Qiang Cai, MD, Division of Digestive Diseases, Emory University School of Medicine, 1365 Clifton Rd, Ste B1262, Atlanta, GA 30322.Atlanta, Georgia, USA
Abstract |
Background |
Microlithiasis has been identified as a cause of idiopathic acute pancreatitis in patients with an intact gallbladder. Microlithiasis has also been identified in the bile of some patients who have undergone cholecystectomy. However, it is unknown whether bile microlithiasis causes postcholecystectomy pain.
Objective |
To identify bile microlithiasis in patients with postcholecystectomy pain and to investigate the therapeutic effect of ursodeoxycholic acid (urso) on such patients with microlithiasis in the bile.
Design |
Prospective randomized trial.
Setting |
Tertiary medical center.
Patients |
Patients with postcholecystectomy pain and bile crystals.
Interventions |
Urso treatment.
Main Outcome Measurements |
The severity and frequency of right upper-quadrant abdominal pain were compared with and without urso treatment, and before and after urso treatment.
Results |
A total of 118 patients with postcholecystectomy pain were screened for the study. Twelve patients (10%) were identified with bile crystals. In the first phase, 6 of these patients received urso treatment, whereas the other 6 patients did not receive urso treatment. In the second phase, the latter 6 patients were given the urso treatment. After using urso for a few months, their biliary-type abdominal pain significantly improved or resolved. In the control group, there was no improvement in symptoms. There was a significant difference between the 2 groups (P = .01).
Limitations |
Single-center, small number of patients.
Conclusions |
This study provided evidence that supports the hypothesis that bile microlithiasis is indeed a cause for postcholecystectomy pain. Patients with such postcholecystectomy pain may benefit from a microscopic examination of bile for crystals or microlithiasis, and urso treatment if bile crystals are identified.
Il testo completo di questo articolo è disponibile in PDF.Abbreviations : CBG, CMC, IV, MRI, RUQ, SOD, urso
Mappa
| See CME section; p. 112. |
Vol 68 - N° 1
P. 69-74 - luglio 2008 Ritorno al numero
Articolo precedente
- Laparoscopy—a historical perspective: are gastroenterologists going to reclaim it?
- H. Juergen Nord
- Should patients with biliary-type pain after cholecystectomy be evaluated for microlithiasis?
- Furqaan Ahmed, Stuart Sherman
Benvenuto su EM|consulte, il riferimento dei professionisti della salute.
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