Extraluminal Atherosclerosis: An Under-recognised Finding in Human Aortocoronary Venous Bypass Grafts - 16/01/13
, Maryam Sadeghian, MD d, Haleh Afshar, MD d, Shadi Kalantarian, MD, MPH d, h, Shahram Sabeti, MD f, Hossein Ahmadi, MD i, Mehrab Marzban, MD i, Foroozan Mohammadi, MD c
Corresponding author at: Center for Outcomes Research and Evaluation Yale/YNHH, One Church Street, Suite #200, New Haven, CT 06510, United States. Tel.: +1 203 764 5887.Riassunto |
Background |
Coronary artery bypass grafting (CABG) is commonly compromised by graft atherosclerosis. Histopathologic studies confirm various forms of atherosclerosis, including positively remodelled lesions in native coronary arteries but there are no histopathologic reports of extraluminal atherosclerosis in vein grafts.
Methods |
We prospectively investigated the histopathologic presence and pattern of extraluminal atherosclerosis in human old vein grafts in a two-year interval among patients undergoing redo-CABG at three university hospitals in Tehran. We separately documented clinical and angiographic findings.
Results |
We evaluated 100 segments from 20 human old vein grafts obtained during the redo CABG. All but four segments demonstrated some degrees of luminal narrowing. Luminal atherosclerotic plaques were detectable in 61 segments. We detected extraluminal atheroscleoris in seven segments. Mean vessel wall thickness was greater in segments containing extraluminal plaques (1.41±0.26mm versus 0.91±0.04mm, P=0.008). Angiographic findings had a modest correlation with presence or absence of luminal atheromatous lesions (Spearman’s rho: 0.331, P=0.007). Angiographic degree of stenosis could not predict the presence of positively remodelled atherosclerotic plaques (Spearman’s rho: −2.21, P=0.073).
Conclusion |
Previous studies suggested positive remodelling in vein grafts. Out study provides histopathologic evidence on extraluminal atherosclerosis in human aortocoronary vein grafts.
Il testo completo di questo articolo è disponibile in PDF.Abbreviations : CABG, HPF, IVUS, NRITLD
Keywords : Atherosclerosis, Vein, Graft, Extraluminal, Positive remodelling
Mappa
 | This study was supported by a research grant from Shahid Beheshti University of Medical Sciences High Research Council. |
Vol 22 - N° 1
P. 19-24 - gennaio 2013 Ritorno al numero
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