Imaging myeloma is often performed when complications occur which may reveal the disease. Since the malignant plasma cell proliferation characteristic of this disease can affect the whole of the bony skeleton to various degrees, examination of the bones should be as complete as possible. The radiographic images must be studied for lytic lesions or signs of diffuse osteopenia, as well for fracture complications such as vertebral compression. Slice imaging has the advantage of being more sensitive and showing extra-osseous extension well. With a CT scan and MRI, spinal compression can be detected or a surgical procedure planned, while MRI or a PET scan can be used to assess extension of the disease and the response to treatment.