Overuse of any class of drugs, Triptans, ergots, opioids, simple, or combination analgesics used to treat acute headaches, especially migraine, can lead to the development of medication overuse headache. People suffering from primary headache types, such as migraine or tension-type headache, are at higher risk to develop chronic headache following the overuse of acute headache drugs. Treatment of medication overuse headache requires withdrawal as an initial step, coincident initiation of preventive treatment, a multidisciplinary setting, and includes education of patients.