Batteryless implantable dual-sensor capsule for esophageal reflux monitoring - 19/03/13
Reprint requests: Shou-jiang Tang, MD, Division of Digestive Diseases, Department of Internal Medicine, 2500 North State Street, Jackson, MS 39216Riassunto |
Background |
Chronic GERD affects approximately 15% of adults in the United States and is one of the most prevalent clinical conditions involving the GI tract. The commercial tools for monitoring GERD include multichannel intraluminal impedance (MII) probes and pH-sensing capsules. However, MII probes cause discomfort, which alters patients' regular activities, whereas the pH-sensing capsule lacks the ability to detect weak or nonacid episodes, misses reflux episodes with similar pH values, and has a limited sampling rate and battery life.
Objective |
To develop and test an implantable batteryless dual-sensor capsule that can be used to diagnose and monitor GERD.
Design |
The implanted capsule is wirelessly powered by an external device. Simulated reflux episodes were created in 3 live porcine models. Impedance and pH data were continuously measured and recorded.
Intervention |
The implant capsule was placed in the esophagus along with a commercial pH-sensing capsule for comparison.
Main Outcome Measurements |
Precise impedance and pH readouts were obtained and compared with those from a commercial pH-sensing capsule.
Results |
The wireless energy supplied by the external unit was strong enough to power the implant. The pH sensor accurately measured pH levels and the impedance sensor precisely located the reflux episodes.
Limitation |
Simulated reflux events in a pig model.
Conclusion |
Our wireless sensors are reliable in operation and provide accurate assessment of simulated reflux episodes. The entire device can potentially be used to diagnose and monitor GERD.
Il testo completo di questo articolo è disponibile in PDF.Abbreviations : BEST, MII, NG
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| DISCLOSURE: Smitha Rao was employed by Med-Worx. University of Texas at Arlington received a subcontract of a National Science Foundation SBIR grant from Med-Worx to J.-C. Chiao's research group for device design and telemetry characterization. The other authors disclosed no financial relationships relevant to this publication. Shou-jiang Tang, H. F. Tibbals, Stuart Spechler, and J.-C. Chiao were listed as the co-inventors of the reported technology. Certain aspects of this technology have been covered in intellectual property filed by the University of Texas Arlington and UT Southwestern. |
Vol 77 - N° 4
P. 649-653 - aprile 2013 Ritorno al numero
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