Clinicopathologic study of node-negative advanced gastric cancer and analysis of factors predicting its recurrence and prognosis - 16/05/13
, Tsung-Hsing Chen, M.D. b, Chun-Jun Lin, M.D. b, Jeng-Hwei Tseng, M.D. c, Ta-Sen Yeh, M.D., Ph.D. a, Tsann-Long Hwang, M.D. a, Yi-Yin Jan, M.D. aAbstract |
Background |
This study aimed to reveal the predictors for the recurrence pattern of gastric cancer (GC) and analyze the prognostic factors in node-negative advanced (T2 to T4) GC after curative resection.
Methods |
Between 1994 and 2006, 448 patients with node-negative advanced GC undergoing radical resection were enrolled in this study. Clinicopathologic factors affecting the recurrence pattern and prognosis for GC were analyzed.
Results |
Location, size, tumor invasion depth, and perineural invasion were associated with tumor recurrence and outcome. T4 status was a predictor for locoregional recurrence and peritoneal seeding, and a large tumor size and the presence of perineural invasion predicted hematogenous spread. Patients with only locoregional recurrence had better survival than those with peritoneal seeding or hematogenous spread.
Conclusions |
In node-negative advanced GC, the prognostic factor differed significantly between locoregional recurrence/peritoneal seeding and hematogenous metastasis. Survival rates were higher in patients with locoregional recurrence alone than in patients with other recurrence patterns.
Il testo completo di questo articolo è disponibile in PDF.Keywords : Advanced gastric adenocarcinoma, Node negative, Recurrence pattern, Prognostic factor
Mappa
| Supported in part by the Chang Gung Medical Research Program, Taiwan (CMRPG 380161), and the grants of Department of Health, Taiwan (DOH99-TD-C-111-006; PMRPG390071). |
Vol 205 - N° 6
P. 623-630 - giugno 2013 Ritorno al numero
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