Impaired Endothelial Function in Adolescents with Type 1 Diabetes Mellitus - 07/03/14
, Stan Van Uum, MD, PhD b, c, Nimira Kanji, MD a, Heather Thiessen-Philbrook, MMath, AStat d, Cheril L. Clarson, BM, BS a
Reprint requests: Farid H. Mahmud, MD, Division of Paediatric Endocrinology, Children’s Hospital of Western Ontario, 800 Commissioners Road East, London, Ontario, Canada N6C 2V5.Riassunto |
Objective |
To evaluate the effect of a high-fat meal on endothelial function in adolescents with type 1 diabetes mellitus (T1D).
Study design |
Twenty-three children with T1D, aged 12 to 18 years, and age- and sex-matched healthy control subjects were assessed for baseline macronutrient intake, and endothelial function was measured both fasting and after a standardized fast-food, high-fat breakfast.
Results |
Endothelial function, assessed noninvasively by peripheral arterial tonometry, was impaired in the T1D group in the fasting state as compared with control subjects (T1D 1.78 ± 0.4, control subjects 2.06 ± 0.4, P = .02), and worsened postprandially in both groups (T1D 1.45 ± 0.3, control subjects 1.71 ± 0.3, P = .01). Both groups demonstrated significantly elevated triglyceride levels 3.5 hours after ingestion of the high-fat meal (T1D 114.8 ± 42.8 and control subjects 126.7 ± 54.9 mg/dL). Nutrient intake in both groups showed higher than recommended intakes of total fat, saturated fat, and cholesterol.
Conclusions |
Patients with T1D exhibited worse endothelial function both before and after a high-fat breakfast than their peers. This suggests that patients with T1D are at greater risk of vascular impairment after a high-fat meal, the cumulative effect of which may contribute to the higher atherosclerotic burden observed in T1D.
Il testo completo di questo articolo è disponibile in PDF.Abbreviations : BP, EF, HDL, LDL, PAT, TG, T1D
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| Supported by research funds granted to FHM by the Lawson Health Research Institute. |
Vol 152 - N° 4
P. 557-562 - aprile 2008 Ritorno al numero
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