Decreased Bone Mineral Density with Off-Label Use of Tenofovir in Children and Adolescents Infected with Human Immunodeficiency Virus - 07/03/14
Doi : 10.1016/j.jpeds.2007.12.020
Julia B. Purdy, RN, MSN a, Rachel I. Gafni, MD a, b, James C. Reynolds, MD c, Steven Zeichner, MD, PhD a, Rohan Hazra, MD a, d, e, ⁎ 
a HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD
b Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD
c Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD
d Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD
e Pediatric Adolescent and Maternal AIDS Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD.
Reprint requests: Rohan Hazra, MD, Pediatric Adolescent and Maternal AIDS Branch, National Institute of Child Health and Human Development, 6100 Executive Boulevard, Room 4B11, Bethesda, MD 20892-7510.Riassunto |
5 of 6 children infected with human immunodeficiency virus (HIV) receiving Tenofovir disoproxil fumarate (TDF) experienced absolute decreases in bone mineral density (BMD). 2 pre-pubertal subjects experienced >6% BMD decreases. 1 subject was the smallest child and experienced a 27% decrease, necessitating withdrawal of TDF. Subsequently, her BMD recovered. Monitoring of children infected with HIV who require treatment with TDF is warranted.
Il testo completo di questo articolo è disponibile in PDF.Abbreviations : BMD, DXA, HAART, HIV, TDF
Mappa
| Supported by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. |
© 2008
Mosby, Inc. Tutti i diritti riservati.
Vol 152 - N° 4
P. 582-584 - aprile 2008 Ritorno al numero
Articolo precedente
- Comida en Venta: After-School Advertising on Spanish-Language Television in the United States
- Darcy A. Thompson, Glenn Flores, Beth E. Ebel, Dimitri A. Christakis
- Performance of QuantiFERON-TB Testing in a Tuberculosis Outbreak at a Primary School
- Paola Molicotti, Alessandra Bua, Graziella Mela, Paolina Olmeo, Renzo Delogu, Silvia Ortu, Leonardo Antonio Sechi, Stefania Zanetti
Benvenuto su EM|consulte, il riferimento dei professionisti della salute.
L'accesso al testo integrale di questo articolo richiede un abbonamento.
Già abbonato a @@106933@@ rivista ?