Insulin-Like Growth Factor-I and -II Levels Are Associated with the Progression of Nonalcoholic Fatty Liver Disease in Obese Children - 25/06/14
, Elena Inzaghi, MD 1, Anna Alisi, BS 3, Daniela Germani, BS 4, Antonella Puglianiello, BS 4, Valerio Nobili, MD 3Abstract |
Objective |
To correlate circulating levels of insulin-like growth factor (IGF)-I, IGF-II, and IGF binding protein (IGFBP)-3 in a population of obese children with biopsy-proven nonalcoholic fatty liver disease (NAFLD) with clinical, biochemical, and histological features.
Study design |
We conducted a cross-sectional study at the Hepatometabolic Unit of the Bambino Gesù Children's Hospital, Rome, Italy. Obese children (42 girls and 57 boys) underwent liver biopsy, anthropometry, biochemical assessment, and IGF system evaluation. Serum concentrations of IGF-I, IGF-II, and IGFBP-3 were measured. The liver biopsy features of each case were graded according to the NAFLD Activity Scoring system. The degrees of steatosis, inflammation, ballooning, and fibrosis were calculated.
Results |
Nonalcoholic steatohepatitis was diagnosed in 14/99 obese subjects. Stepwise regression analysis revealed that IGF-I was the major predictor of ballooning (β = −0.463; P < .0001) and NAFLD activity score (β = −0.457; P < .0001), IGF-I/IGFBP-3 ratio was the major predictor of liver inflammation (β = -0.285; P = .005), and IGF-II was the major predictor of liver fibrosis (β = 0.343; P < .005).
Conclusion |
Circulating levels of IGF-I and IGF-II are associated with the histological stages of NAFLD and may represent novel markers of liver damage progression in obese children.
Il testo completo di questo articolo è disponibile in PDF.Keyword : apoB, BMI, CRP, CV, GH, HOMA-IR, IGF, IGFBP, IL, IR, ISI, NAFLD, NAS, NASH, OGTT, TNF, WC
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| The authors declare no conflicts of interest. |
Vol 165 - N° 1
P. 92-98 - luglio 2014 Ritorno al numero
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