Ethnic differences in the relationship between birth weight and type 2 diabetes mellitus in postmenopausal women - 28/10/14

Doi : 10.1016/j.diabet.2014.03.003

K.K. Ryckman ^a,^⁎ , E. Rillamas-Sun ^b, C.N. Spracklen ^a, R.B. Wallace ^a,^j, L. Garcia ^c, F.A. Tylavsky ^d, B.V. Howard ^e, S. Liu ^f, Y. Song ^f, E.S. LeBlanc ^g, M.V. White ^h, N.I. Parikh ⁱ, J.G. Robinson ^a,^j
^a Department of Epidemiology, University of Iowa, 145 North Riverside Drive, S400 CPHB, Iowa City, IA 52242, United States
^b Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109, United States
^c Department of Public Health Sciences, University of California at Davis, Med Sci 1C, Davis, CA, United States
^d Department of Preventive Medicine, University of Tennessee Health Science Center, 600 Jefferson Avenue, Memphis, TN 38105, United States
^e Medstar Health Research Institute and Georgetown/Howard Universities Center for Clinical and Translational Research, 6525 Belcrest Road #700, Hyattsville, MD, United States
^f Department of Epidemiology, University of California, Box 951740, 27-138 CHS, Los Angeles, CA 90095, United States
^g Kaiser Permanente Center for Health Research, 3800 N Interstate Avenue, Portland, OR 97227, United States
^h Department of Family, Community and Rural Health, The Commonwealth Medical College, Medical Sciences Building, Room 1013, 525 Pine Street, Scranton, PA 18509, United States
ⁱ John A. Burns School of Medicine and Cardiovascular Division, University of Hawaii, The Queens Medical Center, 1301 Punchbowl Street, Honolulu, HI 96813, United States
^j Department of Internal Medicine, University of Iowa, 145 North Riverside Drive, S400 CPHB, Iowa City, United States

^⁎Corresponding author. Tel.: +1 319 384 4155; fax: +1 319 384 4155.

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Abstract

Aim

The objective of this study is to examine the relationship between self-reported birth weight and the adult occurrence of type 2 diabetes mellitus in a large multi-ethnic population of women.

Methods

Baseline data from the Women's Health Initiative Observational Study [n=75,993] was used to examine the association between participant birth weight category and prevalent type 2 diabetes mellitus. Models were adjusted for age, ethnicity, body mass index and other pertinent risk factors. Sub-analyses were performed stratifying by ethnicity.

Results

There was a strong inverse association between birth weight and type 2 diabetes mellitus with a birth weight of <6 pounds (lbs) (OR: 1.16, 95% CI: 1.01, 1.33) significantly associated with an increased risk of type 2 diabetes mellitus and a birth weight of ≥10 lbs (OR: 0.72, 95% CI: 0.57, 0.92) associated with a decreased risk of type 2 diabetes mellitus compared to women who reported their birth weight between 7 and 8 lbs 15 ounces (oz). Stratifying by ethnicity, the inverse association between birth weight and type 2 diabetes mellitus was only apparent in White women, but not Black, Hispanic or Asian women.

Conclusion

Lower birth weight was associated with increased T2D risk in American White and Black post-menopausal women.

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Keywords : Birth weight, Diabetes, Fetal programming

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Introduction

Methods

Results

Baseline characteristics

Birth weight and T2DM

Birth weight and T2DM by ethnicity

Post-hoc power calculations

Discussion

Disclosure of interest

Esportazione

Vol 40 - N° 5

P. 379-385 - novembre 2014 Ritorno al numero

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Ethnic differences in the relationship between birth weight and type 2 diabetes mellitus in postmenopausal women - 28/10/14

Abstract

Aim

Methods

Results

Conclusion

Mappa

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