Sessile serrated polyp prevalence determined by a colonoscopist with a high lesion detection rate and an experienced pathologist - 23/02/15
Abstract |
Background |
The prevalence of sessile serrated adenomas and/or polyps (SSA/Ps) is uncertain.
Objective |
To determine the prevalence of SSA/Ps and SSA/Ps with cytologic dysplasia (SSA/P-CD) by using a colonoscopist with a high lesion detection rate and an expert in serrated lesion pathology.
Design |
Retrospective screening colonoscopy study.
Setting |
Academic endoscopy unit.
Patients |
A total of 1910 average risk, asymptomatic patients aged ≥50 years underwent screening colonoscopy between August 2005 and April 2012 by a single colonoscopist with a high lesion detection rate.
Interventions |
Slides of all lesions in the serrated class proximal to the sigmoid colon and all rectal and sigmoid colon serrated lesions >5 mm in size were reviewed by an experienced GI pathologist.
Main Outcome Measurements |
Prevalence of SSA/Ps, defined as the proportion of patients with ≥1 SSA/P.
Results |
There were 1910 patients, of whom 389 had 656 lesions in the serrated class. Review by the experienced GI pathologist determined a prevalence of SSA/Ps without cytologic dysplasia of 7.4% and SSA/Ps-CD of 0.6% (total SSA/P prevalence 8.1%). SSA/Ps and SSA/Ps-CD comprised 5.6% and 0.3%, respectively, of all resected polyps. The mean size of SSA/Ps was 7.13 mm (standard deviation [SD] 4.66), and 51 of 77 (66.2%) polyps ≥10 mm in the serrated class were SSA/Ps.
Limitations |
Retrospective design.
Conclusion |
A colonoscopist with a high lesion detection rate and an experienced pathologist identified a high prevalence (8.1%) of SSA/Ps in a screening population. SSA/Ps are more common than previously believed.
Il testo completo di questo articolo è disponibile in PDF.Abbreviations : CRC, HP, SSA, SSA/P, SSA/P-CD, SSP, TSA, WHO
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| Disclosure: This work was funded by a gift from Scott and Kay Schurz of Bloomington, Indiana. No other financial relationships relevant to this article were disclosed. |
Vol 81 - N° 3
P. 517-524 - marzo 2015 Ritorno al numero
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