Characterization of effector components from the humoral and cellular immune response stimulated by melanoma cells exhibiting modified IGF-1 expression - 14/03/15
, Huynh-Thien Duc aBenvenuto su EM|consulte, il riferimento dei professionisti della salute.
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Abstract |
Modified melanoma B16 cells inhibited in their IGF-1 expression (B16MOD), on the contrary to the IGF-1 fully expressed parental wild-type (B16WT) counterpart, were shown to stimulate humoral as well as cellular immune responses. Among humoral components, the neutralizing and complement-fixing antibodies of IgM and essentially IgG2 (a+b) isotypes exhibited in vitro and in vivo effects upon tumour growth, while the IgG1 antibody isotype promoted enhanced tumour proliferation. As for the cellular immunity, it was found that the T CD8+ lymphocyte subpopulation remained the main potent and long lasting immune active effector regulating tumour growth.
Il testo completo di questo articolo è disponibile in PDF.Keywords : Modified melanoma cells (B16MOD), Wild-type melanoma cells (B16WT), IGF-1 (insulin-like growth factor-1), Humoral and cellular immune effectors
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Vol 70
P. 53-57 - marzo 2015 Ritorno al numero
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