Sommario

• • ·Will cancer care be a winner in the US election?

    Pagina :1253

     
• • ·BROCADE3: a challenge to the treatment paradigm in BRCA breast cancer?

    Pagina :1254-1255

    Melinda L Telli

     
• • ·Tumour mutational burden as a driver for treatment choice in resistant tumours (and beyond)

    Pagina :1255-1257

    Melissa Bersanelli

     
• • ·The STRASS trial: an important step in the right direction

    Pagina :1257-1258

    Kenneth Cardona

     
• • ·Gastric cancer risk: between genetics and lifestyle

    Pagina :1258-1260

    Massimo Rugge

     
• • ·Ethical concerns regarding private equity in Right to Try in the USA

    Pagina :1260-1262

    Susannah W Lee, Daniel J Hurst

     
• • ·Correction to Lancet Oncol 2019; 20: 193–201

    Pagina :e462

    
• • ·Correction to Lancet Oncol 2020; 21: 796–807

    Pagina :e462

    
• • ·Correction to Lancet Oncol 2020; 21: 1309–16

    Pagina :e462

    
• • ·SSO 2020 virtual meeting

    Pagina :1263

    Cheryl Lai

    Mappa Mappa  
• • ·2020 US election and implications for cancer care

    Pagina :1264-1265

    Mary Beth Nierengarten

     
• • ·Less Survivable Cancers Taskforce calls for faster diagnosis

    Pagina :1265-1266

    Talha Khan Burki

     
• • ·Oncology training in Latin America: are we ready for 2040?

    Pagina :1267-1268

    Narjust Duma, Fabio Ynoe Moraes

      
• • ·Veliparib with carboplatin and paclitaxel in BRCA-mutated advanced breast cancer (BROCADE3): a randomised, double-blind, placebo-controlled, phase 3 trial

    Pagina :1269-1282

    Véronique Diéras, Hyo S Han, Bella Kaufman, Hans Wildiers, Michael Friedlander, Jean-Pierre Ayoub, Shannon L Puhalla, Igor Bondarenko, Mario Campone, Erik H Jakobsen, Mathilde Jalving, Cristina Oprean, Marketa Palácová, Yeon Hee Park, Yaroslav Shparyk, Eduardo Yañez, Nikhil Khandelwal, Madan G Kundu, Matthew Dudley, Christine K Ratajczak, David Maag, Banu K Arun

    Riassunto Riassunto Mappa Mappa   
• • ·Trastuzumab emtansine plus atezolizumab versus trastuzumab emtansine plus placebo in previously treated, HER2-positive advanced breast cancer (KATE2): a phase 2, multicentre, randomised, double-blind trial

    Pagina :1283-1295

    Leisha A Emens, Francisco J Esteva, Mark Beresford, Cristina Saura, Michelino De Laurentiis, Sung-Bae Kim, Seock-Ah Im, Yifan Wang, Roberto Salgado, Aruna Mani, Jigna Shah, Chiara Lambertini, Haiying Liu, Sanne L de Haas, Monika Patre, Sherene Loi

    Riassunto Riassunto Mappa Mappa   
• • ·Circulating tumour DNA analysis to direct therapy in advanced breast cancer (plasmaMATCH): a multicentre, multicohort, phase 2a, platform trial

    Pagina :1296-1308

    Nicholas C Turner, Belinda Kingston, Lucy S Kilburn, Sarah Kernaghan, Andrew M Wardley, Iain R Macpherson, Richard D Baird, Rebecca Roylance, Peter Stephens, Olga Oikonomidou, Jeremy P Braybrooke, Mark Tuthill, Jacinta Abraham, Matthew C Winter, Hannah Bye, Michael Hubank, Heidrun Gevensleben, Ros Cutts, Claire Snowdon, Daniel Rea, David Cameron, Abeer Shaaban, Katrina Randle, Sue Martin, Katie Wilkinson, Laura Moretti, Judith M Bliss, Alistair Ring

    Riassunto Riassunto Mappa Mappa   
• • ·COVID-19 prevalence and mortality in patients with cancer and the effect of primary tumour subtype and patient demographics: a prospective cohort study

    Pagina :1309-1316

    Lennard Y W Lee, Jean-Baptiste Cazier, Thomas Starkey, Sarah E W Briggs, Roland Arnold, Vartika Bisht, Stephen Booth, Naomi A Campton, Vinton W T Cheng, Graham Collins, Helen M Curley, Philip Earwaker, Matthew W Fittall, Spyridon Gennatas, Anshita Goel, Simon Hartley, Daniel J Hughes, David Kerr, Alvin J X Lee, Rebecca J Lee, Siow Ming Lee, Hayley Mckenzie, Chris P Middleton, Nirupa Murugaesu, Tom Newsom-Davis, Anna C Olsson-Brown, Claire Palles, Thomas Powles, Emily A Protheroe, Karin Purshouse, Archana Sharma-Oates, Shivan Sivakumar, Ashley J Smith, Oliver Topping, Chris D Turnbull, Csilla Várnai, Adam D M Briggs, Gary Middleton, Rachel Kerr, UK Coronavirus Cancer Monitoring Project Team, Abigail Gault, Michael Agnieszka, Ahmed Bedair, Aisha Ghaus, Akinfemi Akingboye, Alec Maynard, Alexander Pawsey, Ali Abdulnabi Suwaidan, Alicia Okines, Alison Massey, Amy Kwan, Ana Ferreira, Angelos Angelakas, Anjui Wu, Ann Tivey, Anne Armstrong, Annet Madhan, Annet Pillai, Ashley Poon-King, Bartlomiej Kurec, Caroline Usborne, Caroline Dobeson, Christina Thirlwell, Christian Mitchell, Christopher Sng, Christopher Scrase, Christopher Jingree, Clair Brunner, Claire Fuller, Clare Griffin, Craig Barrington, Daniel Muller, Diego Ottaviani, Duncan Gilbert, Eliana Tacconi, Ellen Copson, Emily Renninson, Emma Cattell, Emma Burke, Fiona Smith, Francesca Holt, Gehan Soosaipillai, Hayley Boyce, Heather Shaw, Helen Hollis, Helen Bowyer, Iris Anil, Jack Illingworth, Jack Gibson, Jaishree Bhosle, James Best, Jane Barrett, Jillian Noble, Joseph Sacco, Joseph Chacko, Julia Chackathayil, Kathryn Banfill, Laura Feeney, Laura Horsley, Lauren Cammaert, Leena Mukherjee, Leonie Eastlake, Louise Devereaux, Lucinda Melcher, Lucy Cook, Mabel Teng, Madeleine Hewish, Madhumita Bhattacharyya, Mahbuba Choudhury, Mark Baxter, Martin Scott-Brown, Matthew Fittall, Michael Tilby, Michael Rowe, Michael Agnieszka, Mohammed Alihilali, Myria Galazi, Nadia Yousaf, Neha Chopra, Nicola Cox, Olivia Chan, Omar Sheikh, Paul Ramage, Paul Greaves, Pauline Leonard, Peter S Hall, Piangfan Naksukpaiboon, Pippa Corrie, Rahul Peck, Rachel Sharkey, Rachel Bolton, Rebecca Sargent, Rema Jyothirmayi, Robert Goldstein, Roderick Oakes, Rohan Shotton, Ruhi Kanani, Ruth Board, Ruth Pettengell, Ryan Claydon, Sam Moody, Samah Massalha, Sangary Kathirgamakarthigeyan, Saoirse Dolly, Sarah Derby, Sarah Lowndes, Sarah Benafif, Sarah Eeckelaers, Sarah Kingdon, Sarah Ayers, Sean Brown, Shawn Ellis, Shefali Parikh, Sian Pugh, Simon Shamas, Simon Wyatt, Simon Grumett, Sin Lau, Yien Ning Sophia Wong, Sophie McGrath, Stephanie Cornthwaite, Stephen Hibbs, Tania Tillet, Taslima Rabbi, Tim Robinson, Tom Roques, Vasileios Angelis, Victoria Woodcock, Victoria Brown, YingYing Peng, Yvette Drew, Zoe Hudson

    Riassunto Riassunto Mappa Mappa   
• • ·Carfilzomib or bortezomib in combination with lenalidomide and dexamethasone for patients with newly diagnosed multiple myeloma without intention for immediate autologous stem-cell transplantation (ENDURANCE): a multicentre, open-label, phase 3, randomised, controlled trial

    Pagina :1317-1330

    Shaji K Kumar, Susanna J Jacobus, Adam D Cohen, Matthias Weiss, Natalie Callander, Avina K Singh, Terri L Parker, Alexander Menter, Xuezhong Yang, Benjamin Parsons, Pankaj Kumar, Prashant Kapoor, Aaron Rosenberg, Jeffrey A Zonder, Edward Faber, Sagar Lonial, Kenneth C Anderson, Paul G Richardson, Robert Z Orlowski, Lynne I Wagner, S Vincent Rajkumar

    Riassunto Riassunto Mappa Mappa   
• • ·Adjuvant radiotherapy versus early salvage radiotherapy following radical prostatectomy (TROG 08.03/ANZUP RAVES): a randomised, controlled, phase 3, non-inferiority trial

    Pagina :1331-1340

    Andrew Kneebone, Carol Fraser-Browne, Gillian M Duchesne, Richard Fisher, Mark Frydenberg, Alan Herschtal, Scott G Williams, Chris Brown, Warick Delprado, Annette Haworth, David J Joseph, Jarad M Martin, John H L Matthews, Jeremy L Millar, Mark Sidhom, Nigel Spry, Colin I Tang, Sandra Turner, Kirsty L Wiltshire, Henry H Woo, Ian D Davis, Tee S Lim, Maria Pearse

    Riassunto Riassunto Mappa Mappa   
• • ·Adjuvant radiotherapy versus early salvage radiotherapy plus short-term androgen deprivation therapy in men with localised prostate cancer after radical prostatectomy (GETUG-AFU 17): a randomised, phase 3 trial

    Pagina :1341-1352

    Paul Sargos, Sylvie Chabaud, Igor Latorzeff, Nicolas Magné, Ahmed Benyoucef, Stéphane Supiot, David Pasquier, Menouar Samir Abdiche, Olivier Gilliot, Pierre Graff-Cailleaud, Marlon Silva, Philippe Bergerot, Pierre Baumann, Yazid Belkacemi, David Azria, Meryem Brihoum, Michel Soulié, Pierre Richaud

    Riassunto Riassunto Mappa Mappa   
• • ·Association of tumour mutational burden with outcomes in patients with advanced solid tumours treated with pembrolizumab: prospective biomarker analysis of the multicohort, open-label, phase 2 KEYNOTE-158 study

    Pagina :1353-1365

    Aurélien Marabelle, Marwan Fakih, Juanita Lopez, Manisha Shah, Ronnie Shapira-Frommer, Kazuhiko Nakagawa, Hyun Cheol Chung, Hedy L Kindler, Jose A Lopez-Martin, Wilson H Miller, Antoine Italiano, Steven Kao, Sarina A Piha-Paul, Jean-Pierre Delord, Robert R McWilliams, David A Fabrizio, Deepti Aurora-Garg, Lei Xu, Fan Jin, Kevin Norwood, Yung-Jue Bang

    Riassunto Riassunto Mappa Mappa   
• • ·Preoperative radiotherapy plus surgery versus surgery alone for patients with primary retroperitoneal sarcoma (EORTC-62092: STRASS): a multicentre, open-label, randomised, phase 3 trial

    Pagina :1366-1377

    Sylvie Bonvalot, Alessandro Gronchi, Cécile Le Péchoux, Carol J Swallow, Dirk Strauss, Pierre Meeus, Frits van Coevorden, Stephan Stoldt, Eberhard Stoeckle, Piotr Rutkowski, Marco Rastrelli, Chandrajit P Raut, Daphne Hompes, Antonino De Paoli, Claudia Sangalli, Charles Honoré, Peter Chung, Aisha Miah, Jean Yves Blay, Marco Fiore, Jean-Jacques Stelmes, Angelo P Dei Tos, Elizabeth H Baldini, Saskia Litière, Sandrine Marreaud, Hans Gelderblom, Rick L Haas

    Riassunto Riassunto Mappa Mappa   
• • ·Genetic risk, incident gastric cancer, and healthy lifestyle: a meta-analysis of genome-wide association studies and prospective cohort study

    Pagina :1378-1386

    Guangfu Jin, Jun Lv, Ming Yang, Mengyun Wang, Meng Zhu, Tianpei Wang, Caiwang Yan, Canqing Yu, Yanbing Ding, Gang Li, Chuanli Ren, Jing Ni, Ruoxin Zhang, Yu Guo, Zheng Bian, Yan Zheng, Nasha Zhang, Yue Jiang, Jiaping Chen, Yanong Wang, Dazhi Xu, Hong Zheng, Ling Yang, Yiping Chen, Robin Walters, Iona Y Millwood, Juncheng Dai, Hongxia Ma, Kexin Chen, Zhengming Chen, Zhibin Hu, Qingyi Wei, Hongbing Shen, Liming Li

    Riassunto Riassunto Mappa Mappa   
• • ·Treatment after progression in the era of immunotherapy

    Pagina :e463

    Salem Billan, Orit Kaidar-Person, Ziv Gil

    Riassunto Riassunto Mappa Mappa  
• • ·Total marrow and total lymphoid irradiation in bone marrow transplantation for acute leukaemia

    Pagina :e477

    Jeffrey Y C Wong, Andrea R Filippi, Marta Scorsetti, Susanta Hui, Ludvig P Muren, Pietro Mancosu

    Riassunto Riassunto Mappa Mappa   
• • ·Demystifying the estimand framework: a case study using patient-reported outcomes in oncology

    Pagina :e488

    Mallorie H Fiero, Madeline Pe, Chana Weinstock, Bellinda L King-Kallimanis, Scott Komo, Heidi D Klepin, Stacy W Gray, Andrew Bottomley, Paul G Kluetz, Rajeshwari Sridhara

    Riassunto Riassunto Mappa Mappa  
• • ·Stewart–Treves syndrome: a rapidly fatal complication of breast cancer treatment

    Pagina :e495

    Andrew Hsu, Robert Matera, Don S Dizon