Sommario

• • ·Cover 1

    Pagina :OFC

    
• • ·Brief Overview of This Month's JACI

    Pagina :3A

    
• • ·Table of Contents

    Pagina :8A

    
• • ·Editorial Board

    Pagina :26A

    
• • ·A Special Thank-You to Our Reviewers

    Pagina :299-302

    

• Reader services

  • ·Information for Readers

    Pagina :28A

    
  • ·News & Notes : Special Annual Meeting Issue

    Pagina :34A

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  • ·CME Activities Calendar

    Pagina :43A

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• News beyond our pages

  • ·News Beyond Our Pages

    Pagina :297-298

    Marc E. Rothenberg, Jean Bousquet

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• Reviews and feature articles

  • ·Current and novel therapeutics in the treatment of systemic lupus erythematosus

    Pagina :303-312

    Cagri Yildirim-Toruner, Betty Diamond

    Riassunto Riassunto Mappa Mappa  
  • ·Current and novel therapeutics in the treatment of systemic lupus erythematosus

    Pagina :313-314

    
  • ·The IgG molecule as a biological immune response modifier: Mechanisms of action of intravenous immune serum globulin in autoimmune and inflammatory disorders

    Pagina :315-323

    Mark Ballow

    Riassunto Riassunto Mappa Mappa  
  • ·The IgG molecule as a biological immune response modifier: Mechanisms of action of intravenous immune globulin in autoimmune and inflammatory disorders

    Pagina :324-325

    
  • ·Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects in 2010

    Pagina :326-335

    Scott H. Sicherer, Donald Y.M. Leung

    Riassunto Riassunto Mappa Mappa  
  • ·Advances in basic and clinical immunology in 2010

    Pagina :336-341

    Javier Chinen, William T. Shearer

    Riassunto Riassunto Mappa Mappa  
  • ·Advances in upper airway diseases and allergen immunotherapy

    Pagina :342-350

    Bradley R. Sabin, Carol A. Saltoun, Pedro C. Avila

    Riassunto Riassunto Mappa Mappa
  • ·Altered T-cell receptor signaling in the pathogenesis of allergic disease

    Pagina :351-354

    Shrimati Datta, Joshua D. Milner

    Riassunto Riassunto Mappa Mappa
  • ·Asthma endotypes: A new approach to classification of disease entities within the asthma syndrome

    Pagina :355-360

    Jan Lötvall, Cezmi A. Akdis, Leonard B. Bacharier, Leif Bjermer, Thomas B. Casale, Adnan Custovic, Robert F. Lemanske, Andrew J. Wardlaw, Sally E. Wenzel, Paul A. Greenberger

    Riassunto Riassunto Mappa Mappa  

• The Editors' choice

  • ·The Editors’ Choice

    Pagina :361-362

    Donald Y.M. Leung, Stanley J. Szefler, Associate Editors of the JACI

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• Asthma and lower airway disease

  • ·The burden of adult asthma in the United States: Evidence from the Medical Expenditure Panel Survey

    Pagina :363

    Patrick W. Sullivan, Vahram H. Ghushchyan, Julia F. Slejko, Vasily Belozeroff, Denise R. Globe, Shao-Lee Lin

    Riassunto Riassunto Mappa Mappa  
  • ·Airway microbiota and bronchial hyperresponsiveness in patients with suboptimally controlled asthma

    Pagina :372

    Yvonne J. Huang, Craig E. Nelson, Eoin L. Brodie, Todd Z. DeSantis, Marshall S. Baek, Jane Liu, Tanja Woyke, Martin Allgaier, Jim Bristow, Jeanine P. Wiener-Kronish, E. Rand Sutherland, Tonya S. King, Nikolina Icitovic, Richard J. Martin, William J. Calhoun, Mario Castro, Loren C. Denlinger, Emily DiMango, Monica Kraft, Stephen P. Peters, Stephen I. Wasserman, Michael E. Wechsler, Homer A. Boushey, Susan V. Lynch, National Heart, Lung, and Blood Institute’s Asthma Clinical Research Network ∗

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  • ·Heterogeneity of severe asthma in childhood: Confirmation by cluster analysis of children in the National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program

    Pagina :382

    Anne M. Fitzpatrick, W. Gerald Teague, Deborah A. Meyers, Stephen P. Peters, Xingnan Li, Huashi Li, Sally E. Wenzel, Shean Aujla, Mario Castro, Leonard B. Bacharier, Benjamin M. Gaston, Eugene R. Bleecker, Wendy C. Moore, National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program ∗

    Riassunto Riassunto Mappa Mappa  
  • ·Effect of day care attendance on sensitization and atopic wheezing differs by Toll-like receptor 2 genotype in 2 population-based birth cohort studies

    Pagina :390

    Adnan Custovic, Janet Rothers, Debbie Stern, Angela Simpson, Ashley Woodcock, Anne L. Wright, Nicolaos C. Nicolaou, Jenny Hankinson, Marilyn Halonen, Fernando D. Martinez

    Riassunto Riassunto Mappa Mappa  
  • ·Effects of omalizumab on changes in pulmonary function induced by controlled cat room challenge

    Pagina :398-405

    Jonathan Corren, Robert A. Wood, Deepen Patel, Jin Zhu, Ashley Yegin, Gitika Dhillon, James E. Fish

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  • ·The Madison Avenue effect: How drug presentation style influences adherence and outcome in patients with asthma

    Pagina :406-411

    Emmanuelle M. Clerisme-Beaty, Susan J. Bartlett, W. Gerald Teague, John Lima, Charles G. Irvin, Rubin Cohen, Mario Castro, Robert A. Wise, Cynthia S. Rand

    Riassunto Riassunto Mappa Mappa  
  • ·Surveillance of the cost of asthma in the 21st century

    Pagina :370-371

    Peter J. Gergen

    

• Rhinitis, sinusitis, and upper airway disease

  • ·Chronic cough and irritable larynx

    Pagina :412-419

    Caterina B. Bucca, Massimiliano Bugiani, Beatrice Culla, Giuseppe Guida, Enrico Heffler, Sabrina Mietta, Antonella Moretto, Giovanni Rolla, Luisa Brussino

    Riassunto Riassunto Mappa Mappa  

• Atopic dermatitis and skin disease

  • ·Peroxisome proliferator–activated receptor γ–mediated suppression of dendritic cell function prevents the onset of atopic dermatitis in NC/Tnd mice

    Pagina :420

    Kyungsook Jung, Akane Tanaka, Hiroshi Fujita, Akira Matsuda, Kumiko Oida, Kaoru Karasawa, Noriko Okamoto, Keitaro Ohmori, Youngheun Jee, Taekyun Shin, Hiroshi Matsuda

    Riassunto Riassunto Mappa Mappa  
  • ·Specificity protein 1 is pivotal in the skin’s antiviral response

    Pagina :430

    Lianghua Bin, Michael D. Howell, Byung Eui Kim, Joanne E. Streib, Clifton F. Hall, Donald Y.M. Leung

    Riassunto Riassunto Mappa Mappa  

• Mechanisms of allergy and clinical immunology

  • ·The extra domain A of fibronectin is essential for allergen-induced airway fibrosis and hyperresponsiveness in mice

    Pagina :439

    Martin Kohan, Andres F. Muro, Reem Bader, Neville Berkman

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  • ·Maternal allergy modulates cord blood hematopoietic progenitor Toll-like receptor expression and function

    Pagina :447-453

    Pia Reece, Amudhinie Thanendran, Lynn Crawford, Meri K. Tulic, Lehana Thabane, Susan L. Prescott, Roma Sehmi, Judah A. Denburg

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  • ·Pollen metabolome analysis reveals adenosine as a major regulator of dendritic cell–primed T_H cell responses

    Pagina :454

    Stefanie Gilles, Agnes Fekete, Xin Zhang, Isabelle Beck, Cornelia Blume, Johannes Ring, Carsten Schmidt-Weber, Heidrun Behrendt, Philippe Schmitt-Kopplin, Claudia Traidl-Hoffmann

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  • ·Toll-like receptor 7 agonists are potent and rapid bronchodilators in guinea pigs

    Pagina :462-469

    Elad H. Kaufman, Allison D. Fryer, David B. Jacoby

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  • ·Differences in innate immune function between allergic and nonallergic children: New insights into immune ontogeny

    Pagina :470

    Meri K. Tulic, Megan Hodder, Anna Forsberg, Suzi McCarthy, Tara Richman, Nina D’Vaz, Anita H.J. van den Biggelaar, Catherine A. Thornton, Susan L. Prescott

    Riassunto Riassunto Mappa Mappa  
  • ·Structural and immunologic cross-reactivity among filarial and mite tropomyosin: Implications for the hygiene hypothesis

    Pagina :479-486

    Helton C. Santiago, Sasisekhar Bennuru, Alexis Boyd, Mark Eberhard, Thomas B. Nutman

    Riassunto Riassunto Mappa Mappa  

• Immunotherapy

  • ·Impact of immunotherapy on blood dendritic cells in patients with Hymenoptera venom allergy

    Pagina :487

    Katharina Dreschler, Kai Bratke, Sebastian Petermann, Andrea Bier, Petra Thamm, Michael Kuepper, J. Christian Virchow, Marek Lommatzsch

    Riassunto Riassunto Mappa Mappa  
  • ·Wasp venom immunotherapy induces activation and homing of CD4⁺CD25⁺ forkhead box protein 3–positive regulatory T cells controlling T_H1 responses

    Pagina :495

    Andreas Kerstan, Christa Albert, Detlef Klein, Eva-B. Bröcker, Axel Trautmann

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  • ·Efficacy and safety of immunotherapy for allergies to Alternaria alternata in children

    Pagina :502

    Piotr Kuna, Jadwiga Kaczmarek, Maciej Kupczyk

    Riassunto Riassunto Mappa Mappa  
  • ·Long-term tolerance after allergen immunotherapy is accompanied by selective persistence of blocking antibodies

    Pagina :509

    Louisa K. James, Mohamed H. Shamji, Samantha M. Walker, Duncan R. Wilson, Petra A. Wachholz, James N. Francis, Mikila R. Jacobson, Ian Kimber, Stephen J. Till, Stephen R. Durham

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• Letters to the Editor

  • ·Diffuse large B-cell lymphoma as presenting feature of Zap-70 deficiency

    Pagina :517-520

    Andrea Newell, Harjit Dadi, Rachel Goldberg, Bo-Yee Ngan, Eyal Grunebaum, Chaim M. Roifman

     
  • ·A lower prevalence of asthma among patients with chronic rhinosinusitis in southern China

    Pagina :520

    Yunping Fan, Shuli Chen, Xiujuan Qu, Kejun Zuo, Xiaomin Li, Jin Huang, Geng Xu, Jiaoping Mi, Huabin Li

     
  • ·Dexamethasone regulation of thymic stromal lymphopoietin receptor expression on mast cells and their precursors

    Pagina :523

    Zoulfia Allakhverdi, Michael R. Comeau, Guy Delespesse

     
  • ·Hypersensitivity to systemic corticosteroids: An infrequent but potentially life-threatening condition

    Pagina :524-528

    Rima Rachid, David Leslie, Lynda Schneider, Frank Twarog

    
  • ·The L412F variant of Toll-like receptor 3 (TLR3) is associated with cutaneous candidiasis, increased susceptibility to cytomegalovirus, and autoimmunity

    Pagina :528-531

    Amit Nahum, Harjit Dadi, Andrea Bates, Chaim M. Roifman

     
  • ·Rhinoconjunctival sensitization to hydrolyzed wheat protein in facial soap can induce wheat-dependent exercise-induced anaphylaxis

    Pagina :531

    Yuma Fukutomi, Yasuharu Itagaki, Masami Taniguchi, Akemi Saito, Hiroshi Yasueda, Takuya Nakazawa, Maki Hasegawa, Hiroyuki Nakamura, Kazuo Akiyama

     
  • ·Polymorphous lymphoproliferative disorder with Hodgkin-like features in common γ-chain–deficient severe combined immunodeficiency

    Pagina :533-535

    Mary A. Slatter, Brian Angus, Kevin Windebank, Alison Taylor, Cathy Meaney, Tracey Lester, Gail Norbury, Sophie Hambleton, Mario Abinun, Terence J. Flood, Andrew J. Cant, Andrew R. Gennery

     
  • ·Human phagocyte defect caused by a Rac2 mutation detected by means of neonatal screening for T-cell lymphopenia

    Pagina :535

    Deborah Accetta, Grant Syverson, Benedetta Bonacci, Sreelatha Reddy, Christine Bengtson, Jill Surfus, Ronald Harbeck, Anna Huttenlocher, William Grossman, John Routes, James Verbsky

     
  • ·Defects in the CD19 complex predispose to glomerulonephritis, as well as IgG1 subclass deficiency

    Pagina :538

    Nicolas Vince, David Boutboul, Gael Mouillot, Nicolas Just, Maria Peralta, Jean-Laurent Casanova, Mary Ellen Conley, Jean-Christophe Bories, Eric Oksenhendler, Marion Malphettes, Claire Fieschi, DEFI Study Group ‡

     
  • ·Common variable immunodeficiency presenting as herpes simplex virus encephalitis

    Pagina :541-543

    Larry Borish, Andrew G. Ayars, Charles H. Kirkpatrick

    
  • ·Hodgkin lymphoma in 2 children with chronic granulomatous disease

    Pagina :543

    Saul Oswaldo Lugo Reyes, Felipe Suarez, Rose-Marie Herbigneaux, Hélène Pacquement, Yves Réguerre, Jean-Pierre Rivière, Maylis de Suremain, Yoann Rose, Jacqueline Feinberg, Nizar Malahoui, Alain Fischer, Stéphane Blanche, Jean-Laurent Casanova, Capucine Picard, Jacinta Bustamante

    
  • ·Two new families with X-linked inhibitor of apoptosis deficiency and a review of all 26 published cases

    Pagina :544-546

    Peter C. Horn, Bernd H. Belohradsky, Christian Urban, Daniela Weber-Mzell, Alfons Meindl, Volker Schuster

     

• Correspondence

  • ·Moderately complex US Food and Drug Administration–cleared method for human IgE antibody serology

    Pagina :547

    Vivian Saper

    
  • ·Reply

    Pagina :547-548

    Robert G. Hamilton

    
  • ·Lack of pretreatment cost-effectiveness and side effects of omalizumab versus prednisone/montelukast on tolerability of immunotherapy

    Pagina :548

    J. Loren Rosenberg

    
  • ·Reply

    Pagina :548-549

    Marc Massanari, Harold Nelson, Thomas Casale, William Busse

    
  • ·Forced expiratory flow between 25% and 75% of vital capacity may be a marker of bronchial impairment in allergic rhinitis

    Pagina :549

    Giorgio Ciprandi, Ignazio Cirillo

     
  • ·Reply

    Pagina :550

    Michael R. Simon, Vernon M. Chinchilli, Brenda R. Phillips, Christine A. Sorkness, Robert F. Lemanske, Stanley J. Szefler, Lynn Taussig, Leonard B. Bacharier, Wayne Morgan

    
  • ·Reply

    Pagina :550-551

    Giorgio Ciprandi, Ignazio Cirillo

    

• Retraction notice

  • ·Retraction notice to “Children with asthma and no URTI, more commonly have rhinovirus in their exhaled breath, than in mucous” : [J Allergy Clin Immunol 2009;123:S171]

    Pagina :551

    E.R. Tovey, D.S.Y. Ng, S. Stelzer-Braid, W.D. Rawlinson, B.G. Oliver