Sommario

• • ·Cover 1

    Pagina :OFC

    
• • ·Brief Overview of This Month's JACI

    Pagina :A5

    
• • ·Table of Contents

    Pagina :A7

    
• • ·Editorial Board

    Pagina :A34

    

• Reader services

  • ·Information for Readers

    Pagina :A36

    
  • ·News & Notes

    Pagina :A38

    Mappa Mappa  
  • ·CME Calendar-AAAAI

    Pagina :A43

    

• Reviews and feature articles

  • ·The intersect of genetics, environment, and microbiota in asthma—perspectives and challenges

    Pagina :781-793

    Howard H.F. Tang, Shu Mei Teo, Peter D. Sly, Patrick G. Holt, Michael Inouye

    Riassunto Riassunto Mappa Mappa  
  • ·The intersect of genetics, environment, and microbiota in asthma—perspectives and challenges

    Pagina :794-795

    
  • ·Investigating asthma heterogeneity through shared and distinct genetics: Insights from genome-wide cross-trait analysis

    Pagina :796-807

    Zhaozhong Zhu, Kohei Hasegawa, Carlos A. Camargo, Liming Liang

    Riassunto Riassunto Mappa Mappa  
  • ·The microbial origins of food allergy

    Pagina :808-813

    Rima Rachid, Emmanuel Stephen-Victor, Talal A. Chatila

    Riassunto Riassunto Mappa Mappa  
  • ·The emerging role of Janus kinase inhibitors in the treatment of autoimmune and inflammatory diseases

    Pagina :814-826

    William Damsky, Danielle Peterson, Julie Ramseier, Badr Al-Bawardy, Hyung Chun, Deborah Proctor, Vibeke Strand, Richard A. Flavell, Brett King

    Riassunto Riassunto Mappa Mappa   
  • ·The role of aspirin desensitization followed by oral aspirin therapy in managing patients with aspirin-exacerbated respiratory disease: A Work Group Report from the Rhinitis, Rhinosinusitis and Ocular Allergy Committee of the American Academy of Allergy, Asthma & Immunology

    Pagina :827-844

    Whitney W. Stevens, Elina Jerschow, Alan P. Baptist, Larry Borish, John V. Bosso, Kathleen M. Buchheit, Katherine N. Cahill, Paloma Campo, Seong H. Cho, Anjeni Keswani, Joshua M. Levy, Anil Nanda, Tanya M. Laidlaw, Andrew A. White

    Riassunto Riassunto Mappa Mappa  

• The Editors' choice

  • ·The Editors’ Choice

    Pagina :845-850

    Zuhair K. Ballas, Associate Editors of the JACI

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• News beyond our pages

  • ·News Beyond Our Pages

    Pagina :851-852

    Marc E. Rothenberg, Jean Bousquet

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• Paradigms and perspectives

  • ·AsthmaMap: An interactive knowledge repository for mechanisms of asthma

    Pagina :853-856

    Alexander Mazein, Olga Ivanova, Irina Balaur, Marek Ostaszewski, Valeriya Berzhitskaya, Tatiana Serebriyskaya, Thomas Ligon, Jan Hasenauer, Bertrand De Meulder, Rupert W. Overall, Ludovic Roy, Richard G. Knowles, Craig E. Wheelock, Sven-Erik Dahlen, Kian Fan Chung, Ian M. Adcock, Graham Roberts, Ratko Djukanovic, Johann Pellet, Piotr Gawron, Rudi Balling, Anke H. Maitland-van der Zee, Reinhard Schneider, Peter J. Sterk, Charles Auffray, U-BIOPRED Study Group,, eTRIKS Consortium

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• COVID-19

  • ·Associations between COVID-19 and skin conditions identified through epidemiology and genomic studies

    Pagina :857

    Matthew T. Patrick, Haihan Zhang, Rachael Wasikowski, Errol P. Prens, Stephan Weidinger, Johann E. Gudjonsson, James T. Elder, Kevin He, Lam C. Tsoi

    Riassunto Riassunto Mappa Mappa  
  • ·COVID-19 in patients with primary and secondary immunodeficiency: The United Kingdom experience

    Pagina :870

    Adrian M. Shields, Siobhan O. Burns, Sinisa Savic, Alex G. Richter, UK PIN COVID-19 Consortium, Ariharan Anantharachagan, Gururaj Arumugakani, Kenneth Baker, Sameer Bahal, William Bermingham, Malini Bhole, Evon Boules, Philip Bright, Siobhan Burns, Betsy Cleave, John Dempster, Lisa Devlin, Fatima Dhalla, Elizabeth Drewe, Christopher Duncan, Magdalena Dziadzio, Shuayb Elkhalifa, Andrew Gennery, Sarah Goddard, Sofia Grigoriadou, Grant Hayman, Archana Herwadkar, Aarnoud Huissoon, Rashmi Jain, Stephen Jolles, Sarah Johnston, Lucy Leeman, Shanti Mahabir, Dylan MacLochlainn, Elizabeth McDermott, Siraj Misbah, Hadeil Morsi, Sai Murng, Sadia Noorani, Rachael O’Brien, Smita Patel, Arthur Price, Alex Richter, Sinisa Savic, Suranjith Seneviratne, Adrian Shields, Anna Shrimpton, Catherine Stroud, Prashantha Vaitla, Nisha Verma

    Riassunto Riassunto Mappa Mappa  
  • ·Commercial immunoglobulin products contain cross-reactive but not neutralizing antibodies against SARS-CoV-2

    Pagina :876-877

    Terrie S. Ahn, Brandon Han, Paul Krogstad, Chantana Bun, Lisa A. Kohn, Maria I. Garcia-Lloret, Robert Damoiseaux, Manish J. Butte

     
  • ·mRNA COVID-19 vaccine is well tolerated in patients with cutaneous and systemic mastocytosis with mast cell activation symptoms and anaphylaxis

    Pagina :877-878

    Tiago Azenha Rama, André Moreira, Mariana Castells

    

• Asthma and lower airway disease

  • ·Network study of nasal transcriptome profiles reveals master regulator genes of asthma

    Pagina :879-893

    Anh N. Do, Yoojin Chun, Galina Grishina, Alexander Grishin, Angela J. Rogers, Benjamin A. Raby, Scott T. Weiss, Alfin Vicencio, Eric E. Schadt, Supinda Bunyavanich

    Riassunto Riassunto Mappa Mappa   
  • ·Genetic analyses identify GSDMB associated with asthma severity, exacerbations, and antiviral pathways

    Pagina :894-909

    Xingnan Li, Stephanie A. Christenson, Brian Modena, Huashi Li, William W. Busse, Mario Castro, Loren C. Denlinger, Serpil C. Erzurum, John V. Fahy, Benjamin Gaston, Annette T. Hastie, Elliot Israel, Nizar N. Jarjour, Bruce D. Levy, Wendy C. Moore, Prescott G. Woodruff, Naftali Kaminski, Sally E. Wenzel, Eugene R. Bleecker, Deborah A. Meyers, NHLBI Severe Asthma Research Program (SARP)

    Riassunto Riassunto Mappa Mappa   
  • ·House dust microbiota in relation to adult asthma and atopy in a US farming population

    Pagina :910-920

    Mi Kyeong Lee, Annah B. Wyss, Megan U. Carnes, Marie Richards, Christine G. Parks, Laura E. Beane Freeman, Peter S. Thorne, David M. Umbach, M. Andrea Azcarate-Peril, Shyamal D. Peddada, Stephanie J. London

    Riassunto Riassunto Mappa Mappa   
  • ·lnc-BAZ2B promotes M2 macrophage activation and inflammation in children with asthma through stabilizing BAZ2B pre-mRNA

    Pagina :921

    Li Xia, Xiang Wang, Lijuan Liu, Jinrong Fu, Wenfeng Xiao, Qiuyan Liang, Xiao Han, Saihua Huang, Licheng Sun, Yajing Gao, Caiyan Zhang, Lan Yang, Libo Wang, Liling Qian, Yufeng Zhou

    Riassunto Riassunto Mappa Mappa  
  • ·A genome-wide association study of asthma hospitalizations in adults

    Pagina :933-940

    Qi Yan, Erick Forno, Esther Herrera-Luis, Maria Pino-Yanes, Ge Yang, Sam Oh, Edna Acosta-Pérez, Donglei Hu, Celeste Eng, Scott Huntsman, José R. Rodriguez-Santana, Michelle M. Cloutier, Glorisa Canino, Esteban G. Burchard, Wei Chen, Juan C. Celedón

    Riassunto Riassunto Mappa Mappa   
  • ·Single-cell transcriptomic analysis reveals key immune cell phenotypes in the lungs of patients with asthma exacerbation

    Pagina :941-954

    Hui Li, Huaqi Wang, Leon Sokulsky, Shaoxia Liu, Rui Yang, Xiaojie Liu, Lujia Zhou, Juan Li, Chun Huang, Fangfang Li, Xu Lei, Hongxia Jia, Jiuling Cheng, Fuguang Li, Ming Yang, Guojun Zhang

    Riassunto Riassunto Mappa Mappa   

• Atopic dermatitis and inflammatory skin disease

  • ·Staphylococcus epidermidis protease EcpA can be a deleterious component of the skin microbiome in atopic dermatitis

    Pagina :955

    Laura Cau, Michael R. Williams, Anna M. Butcher, Teruaki Nakatsuji, Jeffrey S. Kavanaugh, Joyce Y. Cheng, Faiza Shafiq, Kyle Higbee, Tissa R. Hata, Alexander R. Horswill, Richard L. Gallo

    Riassunto Riassunto Mappa Mappa  

• Food allergy and gastrointestinal disease

  • ·Association of frequent moisturizer use in early infancy with the development of food allergy

    Pagina :967

    Michael R. Perkin, Kirsty Logan, Tom Marrs, Suzana Radulovic, Joanna Craven, Robert J. Boyle, Joanne R. Chalmers, Hywel C. Williams, Serge A. Versteeg, Ronald van Ree, Gideon Lack, Carsten Flohr, EAT Study Team, Louise Young, Victoria Offord, Mary DeSousa, Jason Cullen, Katherine Taylor, Anna Tseng, Bunmi Raji, Sarah Byrom, Gillian Regis, Charlie Bigwood, Charlotte Stedman, Sharon Tonner, Emily Banks, Yasmin Kahnum, Rachel Babic, Ben Stockwell, Erin Thompson, Lorna Wheatley, Devi Patkunam, Kerry Richards, Ewa Pietraszewicz, Alick Stephens, Asha Sudra, Victor Turcanu

    Riassunto Riassunto Mappa Mappa  
  • ·Ara h 2–specific IgE is superior to whole peanut extract–based serology or skin prick test for diagnosis of peanut allergy in infancy

    Pagina :977

    Corinne Keet, Mihaela Plesa, Daria Szelag, Wayne Shreffler, Robert Wood, Joan Dunlop, Roger Peng, Jennifer Dantzer, Robert G. Hamilton, Alkis Togias, Michael Pistiner

    Riassunto Riassunto Mappa Mappa  
  • ·Age and eczema severity, but not family history, are major risk factors for peanut allergy in infancy

    Pagina :984

    Corinne Keet, Michael Pistiner, Mihaela Plesa, Daria Szelag, Wayne Shreffler, Robert Wood, Joan Dunlop, Roger Peng, Jennifer Dantzer, Alkis Togias

    Riassunto Riassunto Mappa Mappa  
  • ·Epicutaneous immunotherapy for treatment of peanut allergy: Follow-up from the Consortium for Food Allergy Research

    Pagina :992

    Amy M. Scurlock, A. Wesley Burks, Scott H. Sicherer, Donald Y.M. Leung, Edwin H. Kim, Alice K. Henning, Peter Dawson, Robert W. Lindblad, M. Cecilia Berin, Christine B. Cho, Wendy F. Davidson, Marshall Plaut, Hugh A. Sampson, Robert A. Wood, Stacie M. Jones, Consortium for Food Allergy Research (CoFAR)

    Riassunto Riassunto Mappa Mappa  

• Anaphylaxis, drug allergy, urticaria, and angioedema

  • ·A randomized double-blind, placebo-controlled study of omalizumab for idiopathic anaphylaxis

    Pagina :1004

    Melody C. Carter, Irina Maric, Erica H. Brittain, Yun Bai, Keith Lumbard, Hyejeong Bolan, Daly Cantave, Linda M. Scott, Dean D. Metcalfe

    Riassunto Riassunto Mappa Mappa  

• Biologics and immunotherapy

  • ·Intralymphatic immunotherapy improves grass pollen allergic rhinoconjunctivitis: A 3-year randomized placebo-controlled trial

    Pagina :1011-1019

    Søren Helbo Skaarup, Johannes Martin Schmid, Tina Skjold, Ole Graumann, Hans Jürgen Hoffmann

    Riassunto Riassunto Mappa Mappa   
  • ·A 300 IR sublingual tablet is an effective, safe treatment for house dust mite–induced allergic rhinitis: An international, double-blind, placebo-controlled, randomized phase III clinical trial

    Pagina :1020

    Pascal Demoly, Jonathan Corren, Peter Creticos, Frédéric De Blay, Philippe Gevaert, Peter Hellings, Krzysztof Kowal, Martine Le Gall, Natalia Nenasheva, Giovanni Passalacqua, Oliver Pfaar, Miguel Tortajada-Girbés, Carmen Vidal, Margitta Worm, Thomas B. Casale

    Riassunto Riassunto Mappa Mappa  

• Mechanisms of allergy/immunology

  • ·Shared DNA methylation signatures in childhood allergy: The MeDALL study

    Pagina :1031-1040

    Cheng-Jian Xu, Olena Gruzieva, Cancan Qi, Ana Esplugues, Ulrike Gehring, Anna Bergström, Dan Mason, Leda Chatzi, Daniela Porta, Karin C. Lodrup Carlsen, Nour Baïz, Anne-Marie Madore, Harri Alenius, Bianca van Rijkom, Soesma A. Jankipersadsing, Pieter van der Vlies, Inger Kull, Marianne van Hage, Mariona Bustamante, Aitana Lertxundi, Matias Torrent, Gillian Santorelli, Maria Pia Fantini, Vegard Hovland, Giancarlo Pesce, the BIOS Consortium, Nanna Fyhrquist, Tiina Laatikainen, Martijn C. Nawijn, Yang Li, Cisca Wijmenga, Mihai G. Netea, Jean Bousquet, Josep M. Anto, Catherine Laprise, Tari Haahtela, Isabella Annesi-Maesano, Kai-Håkon Carlsen, Davide Gori, Manolis Kogevinas, John Wright, Cilla Söderhäll, Judith M. Vonk, Jordi Sunyer, Erik Melén, Gerard H. Koppelman

    Riassunto Riassunto Mappa Mappa   
  • ·Human milk oligosaccharide profiles and allergic disease up to 18 years

    Pagina :1041-1048

    Caroline J. Lodge, Adrian J. Lowe, Elasma Milanzi, Gayan Bowatte, Michael J. Abramson, Helen Tsimiklis, Christine Axelrad, Bianca Robertson, Aaron E. Darling, Cecilie Svanes, Matthias Wjst, Shyamali C. Dharmage, Lars Bode

    Riassunto Riassunto Mappa Mappa   
  • ·Microbiome-induced antigen-presenting cell recruitment coordinates skin and lung allergic inflammation

    Pagina :1049

    Niki D. Ubags, Aurélien Trompette, Julie Pernot, Britt Nibbering, Nicholas C. Wong, Céline Pattaroni, Alexis Rapin, Laurent P. Nicod, Nicola L. Harris, Benjamin J. Marsland

    Riassunto Riassunto Mappa Mappa  
  • ·Notch signaling contributes to the establishment of sustained unresponsiveness to food allergens by oral immunotherapy

    Pagina :1063

    Toshiyuki Yoneyama, Nobuhiro Nakano, Mutsuko Hara, Hiromichi Yamada, Kumi Izawa, Koichiro Uchida, Ayako Kaitani, Tomoaki Ando, Jiro Kitaura, Yoshikazu Ohtsuka, Hideoki Ogawa, Ko Okumura, Toshiaki Shimizu

    Riassunto Riassunto Mappa Mappa  

• Translational and clinical immunology

  • ·Allergome-wide peptide microarrays enable epitope deconvolution in allergen-specific immunotherapy

    Pagina :1077-1086

    Maria Mikus, Arash Zandian, Ronald Sjöberg, Carl Hamsten, Björn Forsström, Morgan Andersson, Lennart Greiff, Mathias Uhlén, Mattias Levin, Peter Nilsson, Marianne van Hage, Mats Ohlin

    Riassunto Riassunto Mappa Mappa   

• Brief report

  • ·Clearance of apoptotic cells by lung alveolar macrophages prevents development of house dust mite-induced asthmatic lung inflammation

    Pagina :1087

    Haruka Miki, Hong Pei, Donald Tom Gracias, Joel Linden, Michael Croft

    Riassunto Riassunto Mappa Mappa  

• Letters to the Editor

  • ·Enhancing the prediction of childhood asthma remission: Integrating clinical factors with microRNAs

    Pagina :1093

    Alberta L. Wang, Jiang Li, Alvin T. Kho, Michael J. McGeachie, Kelan G. Tantisira

     
  • ·A deoxyribonuclease 1–like 3 genetic variant associates with asthma exacerbations

    Pagina :1095

    Esther Herrera-Luis, Fabian Lorenzo-Diaz, Lesly-Anne Samedy-Bates, Celeste Eng, Jesús Villar, Jose R. Rodriguez-Santana, Esteban G. Burchard, Maria Pino-Yanes

     
  • ·Nasopharyngeal Haemophilus and local immune response during infant respiratory syncytial virus infection

    Pagina :1097

    Meghan H. Shilts, Christian Rosas-Salazar, Kedir N. Turi, Devi Rajan, Seesandra V. Rajagopala, Megan F. Patterson, Tebeb Gebretsadik, Larry J. Anderson, R. Stokes Peebles, Tina V. Hartert, Suman R. Das

     
  • ·Coagulation factors induce human skin mast cell and basophil degranulation via activation of complement 5 and the C5a receptor

    Pagina :1101

    Yuhki Yanase, Yoshimi Matsuo, Shunsuke Takahagi, Tomoko Kawaguchi, Kazue Uchida, Kaori Ishii, Akio Tanaka, Daiki Matsubara, Koichiro Ozawa, Michihiro Hide

     
  • ·Long-term outcomes for adults with chronic granulomatous disease in the United Kingdom

    Pagina :1104-1107

    Luiza C. Campos, Giulia Di Colo, Vruti Dattani, Helen Braggins, Dinakantha Kumararatne, Anthony P. Williams, Hana Alachkar, Stephen Jolles, Alexandra Battersby, Theresa Cole, Suzanne Elcombe, Kimberly C. Gilmour, David Goldblatt, Andrew R. Gennery, Jamanda Haddock, David M. Lowe, Siobhan O. Burns

      
  • ·Secukinumab lowers expression of ACE2 in affected skin of patients with psoriasis

    Pagina :1107

    James G. Krueger, Dedee F. Murrell, Sandra Garcet, Kristina Navrazhina, Patricia C. Lee, Elisa Muscianisi, Andrew Blauvelt

     
  • ·Novel insights into the TRPV3-mediated itch in atopic dermatitis

    Pagina :1110

    Ciara Larkin, Weiwei Chen, Imre Lőrinc Szabó, Chunxu Shan, Zsolt Dajnoki, Andrea Szegedi, Timo Buhl, Yuanyuan Fan, Sandra O'Neill, Dermot Walls, Wenke Cheng, Song Xiao, Jiafu Wang, Jianghui Meng

     

• Correspondence

  • ·A tribute to eosinophils from a comparative and evolutionary perspective

    Pagina :1115-1116

    Nicole I. Stacy, Steven J. Ackerman

     
  • ·Inhaled corticosteroids and angiotensin-converting enzyme-2 in COPD

    Pagina :1117

    Brian Lipworth, Rory Chan, Chris Kuo

    
  • ·Reply

    Pagina :1117-1118

    Hugo Farne, Aran Singanayagam

    
  • ·Does giving infant formula to prevent cow’s milk allergy hinder breast-feeding?

    Pagina :1118

    Keiko Nanishi, Hiroko Hongo, Kanae Tada

    
  • ·Reply

    Pagina :1118-1119

    Tetsuhiro Sakihara, Kenta Otsuji, Yohei Arakaki, Kazuya Hamada, Shiro Sugiura, Komei Ito

    
  • ·Is the “probable” category required in the diagnosis of ABPA?

    Pagina :1119-1121

    Valliappan Muthu, Ritesh Agarwal

    
  • ·Reply

    Pagina :1121

    Tsuyoshi Oguma, Koichiro Asano

    

• Corrigendum

  • ·Corrigendum

    Pagina :1122