Sommario

• • ·Cover 1

    Pagina :OFC

    
• • ·Brief Overview of This Month's JACI

    Pagina :A9

    
• • ·Table of Contents

    Pagina :A11

    
• • ·Editorial Board

    Pagina :A27

    

• Reader services

  • ·Information for Readers

    Pagina :A28

    
  • ·News & Notes

    Pagina :A30

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  • ·CME Calendar-AAAAI

    Pagina :A37

    

• Reviews and feature articles

  • ·Epithelial barrier regulation, antigen sampling, and food allergy

    Pagina :493-502

    Joan M. Cook-Mills, Lauren N. Emmerson

    Riassunto Riassunto Mappa Mappa  
  • ·Impact of the mucosal milieu on antibody responses to allergens

    Pagina :503-512

    Andrea Cerutti, Martyna Filipska, Xavi Marcos Fa, Roser Tachó-Piñot

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  • ·Enteric nervous system and intestinal epithelial regulation of the gut-brain axis

    Pagina :513-522

    Laura R. Dowling, Michael R. Strazzari, Simon Keely, Gerard E. Kaiko

    Riassunto Riassunto Mappa Mappa  
  • ·Gut microbiome and breast-feeding: Implications for early immune development

    Pagina :523-534

    Erin C. Davis, Vanessa P. Castagna, David A. Sela, Margaret A. Hillard, Samantha Lindberg, Nicholas J. Mantis, Antti E. Seppo, Kirsi M. Järvinen

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  • ·Applying dissemination and implementation research methods to translate a school-based asthma program

    Pagina :535-548

    Stanley J. Szefler, Lisa Cicutto, Sarah E. Brewer, Melanie Gleason, Arthur McFarlane, Lisa Ross DeCamp, John T. Brinton, Amy G. Huebschmann

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  • ·Introducing thymus for promoting transplantation tolerance

    Pagina :549-556

    Zachary W. Fitch, Lillian Kang, Jie Li, Stuart J. Knechtle, Joseph W. Turek, Allan D. Kirk, M. Louise Markert, Jean Kwun

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  • ·Optimizing asthma management: Role of long-acting muscarinic antagonists

    Pagina :557-568

    Thomas B. Casale, Michael B. Foggs, Ronald C. Balkissoon

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• The Editors' choice

  • ·The Editors’ Choice

    Pagina :569-574

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• News beyond our pages

  • ·News Beyond Our Pages

    Pagina :575-576

    Marc E. Rothenberg, Jean Bousquet

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• Paradigms and perspectives

  • ·Environmental sensing mechanisms in intestinal homeostasis

    Pagina :577-579

    Alyssa Mitson-Salazar, Ruslan Medzhitov

     
  • ·Succinate and tuft cells: How does this sensory process interface with food allergy?

    Pagina :580-582

    Katherine F. Nico, Miles D.W. Tyner, Michael R. Howitt

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• Editorials

  • ·“Where are they now?” Catching up with the 2017 AAAAI Faculty Development Awardees

    Pagina :583-584

    Zuhair K. Ballas

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  • ·Insights into the biology of IL-9 in asthma

    Pagina :585-586

    Taylor A. Doherty, David H. Broide

     
  • ·Microbiome links breast-feeding and asthma protection: A cohort study helps elucidate this underlying player

    Pagina :587-588

    Leyao Wang, Andrew T. DeWan

     
  • ·Eosinophils apply a handbrake to plasmacytoid dendritic cell antiviral immunity in asthma

    Pagina :589-591

    Simon Phipps, Daniel Ryan Howard, Rhiannon Bree Werder

     
  • ·Chronic rhinosinusitis is associated with non–cystic fibrosis bronchiectasis: A new clinical implication?

    Pagina :592-593

    Jarkko Mäntylä, Paula Kauppi, Sanna Toppila-Salmi

    

• COVID-19

  • ·Angiotensin II induces reactive oxygen species, DNA damage, and T-cell apoptosis in severe COVID-19

    Pagina :594

    Lucy Kundura, Sandrine Gimenez, Renaud Cezar, Sonia André, Mehwish Younas, Yea-Lih Lin, Pierre Portalès, Claire Lozano, Charlotte Boulle, Jacques Reynes, Thierry Vincent, Clément Mettling, Philippe Pasero, Laurent Muller, Jean-Yves Lefrant, Claire Roger, Pierre-Géraud Claret, Sandra Duvnjak, Paul Loubet, Albert Sotto, Tu-Anh Tran, Jérôme Estaquier, Pierre Corbeau

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• Asthma and lower airway disease

  • ·Epithelial cell responses to rhinovirus identify an early-life–onset asthma phenotype in adults

    Pagina :604-611

    Eugene H. Chang, Nima Pouladi, Stefano Guerra, Jana Jandova, Alexander Kim, Haiquan Li, Jianrong Li, Wayne Morgan, Debra A. Stern, Amanda L. Willis, Yves A. Lussier, Fernando D. Martinez

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  • ·Exclusive breast-feeding, the early-life microbiome and immune response, and common childhood respiratory illnesses

    Pagina :612-621

    Christian Rosas-Salazar, Meghan H. Shilts, Zheng-Zheng Tang, Qilin Hong, Kedir N. Turi, Brittney M. Snyder, Derek A. Wiggins, Christian E. Lynch, Tebeb Gebretsadik, R. Stokes Peebles, Larry J. Anderson, Suman R. Das, Tina V. Hartert

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  • ·Genome-wide study of early and severe childhood asthma identifies interaction between CDHR3 and GSDMB

    Pagina :622-630

    Anders U. Eliasen, Casper Emil T. Pedersen, Morten A. Rasmussen, Ni Wang, Matteo Soverini, Amelie Fritz, Jakob Stokholm, Bo L. Chawes, Andréanne Morin, Jette Bork-Jensen, Niels Grarup, Oluf Pedersen, Torben Hansen, Allan Linneberg, Preben B. Mortensen, David M. Hougaard, Jonas Bybjerg-Grauholm, Marie Bækvad-Hansen, Ole Mors, Merete Nordentoft, Anders D. Børglum, Thomas Werge, Esben Agerbo, Cilla Söderhall, Matthew C. Altman, Anna H. Thysen, Chris G. McKennan, Susanne Brix, James E. Gern, Carole Ober, Tarunveer S. Ahluwalia, Hans Bisgaard, Anders G. Pedersen, Klaus Bønnelykke

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• Rhinitis, sinusitis, and ocular allergy

  • ·Lirentelimab for severe and chronic forms of allergic conjunctivitis

    Pagina :631-639

    Stephen D. Anesi, Joseph Tauber, Quan Dong Nguyen, Peter Chang, Gregg J. Berdy, Charles C. Lin, David S. Chu, H. Terry Levine, Andrew D. Fernandez, Neeta Roy, Penny A. Asbell, Andrea M. Kantor, Alan T. Chang, Bhupinder Singh, Bradford A. Youngblood, Bennie H. Jeng, Vishal Jhanji, Henrik S. Rasmussen, C. Stephen Foster

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• Atopic dermatitis and inflammatory skin disease

  • ·Signaling sphingolipids are biomarkers for atopic dermatitis prone to disseminated viral infections

    Pagina :640-648

    Evgeny Berdyshev, Elena Goleva, Irina Bronova, Anna Sofia Bronoff, Joanne E. Streib, Kathryn A. Vang, Brittany N. Richers, Patricia Taylor, Lisa Beck, Miguel Villarreal, Keli Johnson, Gloria David, Mark K. Slifka, Jon Hanifin, Donald Y.M. Leung

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• Food allergy and gastrointestinal disease

  • ·Esophageal remodeling in eosinophilic esophagitis: Relationships to luminal captured biomarkers of inflammation and periostin

    Pagina :649

    Amanda B. Muir, Steven J. Ackerman, Zhaoxing Pan, Alain Benitez, Cassandra Burger, Jonathan M. Spergel, Glenn T. Furuta, Joshua Rothman, Benjamin J. Wilkins, Michael A. Arnold, Lauren Dolinsky, Milica Grozdanovic, Calies Menard-Katcher

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  • ·The natural history of peanut and egg allergy in children up to age 6 years in the HealthNuts population-based longitudinal study

    Pagina :657

    Rachel L. Peters, Imma Guarnieri, Mimi L.K. Tang, Adrian J. Lowe, Shyamali C. Dharmage, Kirsten P. Perrett, Lyle C. Gurrin, Jennifer J. Koplin

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• Mechanisms of allergy/immunology

  • ·Eosinophil-mediated suppression and anti–IL-5 enhancement of plasmacytoid dendritic cell interferon responses in asthma

    Pagina :666-675

    Kimberly A. Dill-McFarland, Justin T. Schwartz, Hongfang Zhao, Baomei Shao, Patricia C. Fulkerson, Matthew C. Altman, Michelle A. Gill

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  • ·Rab44 regulates murine mast cell–driven anaphylaxis through kinesin-1–dependent secretory granule translocation

    Pagina :676-689

    Cyril Longé, Manuela Bratti, Mathieu Kurowska, Shamila Vibhushan, Pierre David, Valère Desmeure, Jian-Dong Huang, Alain Fischer, Geneviève de Saint Basile, Fernando E. Sepulveda, Ulrich Blank, Gaël Ménasché

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• Translational and clinical immunology

  • ·Mechanistic insights into the antipruritic effects of lebrikizumab, an anti–IL-13 mAb

    Pagina :690-700

    Yannick Miron, Paul E. Miller, Chloe Hughes, Tim Indersmitten, Ethan A. Lerner, Ferda Cevikbas

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• Epidemiology and health care delivery

  • ·Strong and consistent associations of precedent chronic rhinosinusitis with risk of non–cystic fibrosis bronchiectasis

    Pagina :701

    Brian S. Schwartz, Saba A. Al-Sayouri, Jonathan S. Pollak, Annemarie G. Hirsch, Robert Kern, Bruce Tan, Atsushi Kato, Robert P. Schleimer, Anju T. Peters

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• Brief reports

  • ·Atopic dermatitis and risk of autoimmune conditions: Population-based cohort study

    Pagina :709-713

    Simon de Lusignan, Helen Alexander, Conor Broderick, John Dennis, Andrew McGovern, Claire Feeney, Carsten Flohr

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  • ·Multiscale study of the oral and gut environments in children with high- and low-threshold peanut allergy

    Pagina :714

    Lingdi Zhang, Yoojin Chun, Hsi-en Ho, Zoe Arditi, Tracy Lo, Swathy Sajja, Rebecca Rose, Drew Jones, Julie Wang, Scott Sicherer, Supinda Bunyavanich

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  • ·Clinical and molecular implications of RGS2 promoter genetic variation in severe asthma

    Pagina :721

    Juan Carlos Cardet, Donghwa Kim, Eugene R. Bleecker, Thomas B. Casale, Elliot Israel, David Mauger, Deborah A. Meyers, Elizabeth Ampleford, Gregory A. Hawkins, Yaping Tu, Stephen B. Liggett, Victor E. Ortega, SARP3 investigators, Bruce Levy, Wanda Phipatanakul, Nizar Jarjour, Sally Wenzel, Mario Castro, John Fahy, Benjamin Gaston, William Teague, Serpil Erzurum, Anne-Marie Irani, Wendy Moore, Anne Fitzpatrick

    Riassunto Riassunto Mappa Mappa  
  • ·Untargeted metabolomic profiling identifies disease-specific and outcome-related signatures in chronic rhinosinusitis

    Pagina :727

    Jing-Xian Li, Zhe-Zheng Wang, Guan-Ting Zhai, Cai-Ling Chen, Ke-Zhang Zhu, Ze Yu, Zheng Liu

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• Corrigendum

  • ·Corrigendum

    Pagina :736-737