Sommario

• • ·Cover 1

    Pagina :OFC

    
• • ·Brief Overview of This Month's JACI

    Pagina :A1

    
• • ·Table of Contents

    Pagina :A3

    
• • ·Editorial Board

    Pagina :A24

    

• Reader services

  • ·Information for Readers

    Pagina :A33

    
  • ·News & Notes

    Pagina :A34

    Mappa Mappa
  • ·CME Calendar-AAAAI

    Pagina :A37

    

• Reviews and feature articles

  • ·The virome in allergy and asthma: A nascent, ineffable player

    Pagina :1347-1351

    Leonardos Mageiros, Spyridon Megremis, Nikolaos G. Papadopoulos

    Riassunto Riassunto Mappa Mappa  
  • ·The respiratory microbiome in childhood asthma

    Pagina :1352-1367

    Gina J. van Beveren, Hager Said, Marlies A. van Houten, Debby Bogaert

    Riassunto Riassunto Mappa Mappa  
  • ·The mycobiome in atopic diseases: Inducers and triggers

    Pagina :1368-1375

    Thais Glatthardt, Erik van Tilburg Bernardes, Marie-Claire Arrieta

    Riassunto Riassunto Mappa Mappa  
  • ·The SARS-CoV-2 pandemic and asthma: What we have learned and what is still unknown

    Pagina :1376-1381

    Christa McPhee, Kateryna Yevdokimova, Linda Rogers, Monica Kraft

    Riassunto Riassunto Mappa Mappa  
  • ·Breakthroughs in understanding and treating eosinophilic gastrointestinal diseases presented at the CEGIR/TIGERs Symposium at the 2022 American Academy of Allergy, Asthma & Immunology Meeting

    Pagina :1382-1393

    Mirna Chehade, Benjamin L. Wright, Dan Atkins, Seema S. Aceves, Steven J. Ackerman, Amal H. Assa’ad, Maureen Bauer, Margaret H. Collins, Scott P. Commins, Carla M. Davis, Evan S. Dellon, Bethan Doerfler, Gerald J. Gleich, Sandeep K. Gupta, David A. Hill, Elizabeth T. Jensen, David Katzka, Kara Kliewer, Ellyn Kodroff, Leah C. Kottyan, Shay Kyle, Amanda B. Muir, Robert D. Pesek, Kathryn Peterson, Wayne G. Shreffler, Jonathan M. Spergel, Mary Jo Strobel, Joshua Wechsler, Nives Zimmermann, Glenn T. Furuta, Marc E. Rothenberg

    Riassunto Riassunto Mappa Mappa  
  • ·The role of Janus kinase signaling in the pathology of atopic dermatitis

    Pagina :1394-1404

    Emma Guttman-Yassky, Alan D. Irvine, Patrick M. Brunner, Brian S. Kim, Mark Boguniewicz, Julie Parmentier, Andrew M. Platt, Kenji Kabashima

    Riassunto Riassunto Mappa Mappa  

• The Editors' choice

  • ·The Editors’ Choice

    Pagina :1405-1411

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• News beyond our pages

  • ·News beyond our pages

    Pagina :1412-1413

    Marc E. Rothenberg, Jean Bousquet

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• Paradigms and perspectives

  • ·Prenatal and perinatal influences on the microbiome: Clinical implications

    Pagina :1414-1416

    Kathleen A. Lee-Sarwar, Yang-Yu Liu, Augusto A. Litonjua, Scott T. Weiss

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  • ·Commensal collaborations: Food allergy and the microbiome

    Pagina :1417-1419

    Zoe Arditi, Supinda Bunyavanich

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• Editorial

  • ·The chicken or the egg: The role of IL-6 in pediatric obese and allergen-exposed asthma

    Pagina :1420-1422

    Kathryn E. Kyler, Bridgette L. Jones

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• Asthma and lower airway disease

  • ·Polygenic risk scores identify heterogeneity in asthma and chronic obstructive pulmonary disease

    Pagina :1423-1432

    Matthew Moll, Joanne E. Sordillo, Auyon J. Ghosh, Lystra P. Hayden, Gregory McDermott, Michael J. McGeachie, Amber Dahlin, Anshul Tiwari, Monica G. Manmadkar, Eric D. Abston, Chandan Pavuluri, Aabida Saferali, Sofina Begum, John P. Ziniti, Amund Gulsvik, Per S. Bakke, Hugues Aschard, Carlos Iribarren, Craig P. Hersh, Jeffrey A. Sparks, Brian D. Hobbs, Jessica A. Lasky-Su, Edwin K. Silverman, Scott T. Weiss, Ann Chen Wu, Michael H. Cho

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  • ·Functional immunophenotyping of blood neutrophils identifies novel endotypes of viral response in preschool children with recurrent wheezing

    Pagina :1433-1443

    Anne M. Fitzpatrick, Ahmad F. Mohammad, Min Huang, Susan T. Stephenson, James Patrignani, Rishikesan Kamaleswaran, Jocelyn R. Grunwell

    Riassunto Riassunto Mappa Mappa   

• Rhinitis, sinusitis, and ocular allergy

  • ·Hypoxia-inducible factor 1α activates the NLRP3 inflammasome to regulate epithelial differentiation in chronic rhinosinusitis

    Pagina :1444

    Bing Zhong, Silu Sun, Kai Sen Tan, Hsiao Hui Ong, Jintao Du, Feng Liu, Yafeng Liu, Shixi Liu, Luo Ba, Jing Li, De Yun Wang, Jing Liu

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• Atopic dermatitis and inflammatory skin disease

  • ·Dupilumab strengthens herpes simplex virus type 1–specific immune responses in atopic dermatitis

    Pagina :1460

    Stephan Traidl, Leonard Harries, Petra Kienlin, Gabriele Begemann, Lennart M. Roesner, Thomas Werfel

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  • ·Systemic treatments for atopic dermatitis (eczema): Systematic review and network meta-analysis of randomized trials

    Pagina :1470-1492

    Alexandro W.L. Chu, Melanie M. Wong, Daniel G. Rayner, Gordon H. Guyatt, Juan Pablo Díaz Martinez, Renata Ceccacci, Irene X. Zhao, Eric McMullen, Archita Srivastava, Jason Wang, Aaron Wen, Fang Chi Wang, Romina Brignardello-Petersen, Ariel Izcovich, Paul Oykhman, Kathryn E. Wheeler, Julie Wang, Jonathan M. Spergel, Jasvinder A. Singh, Jonathan I. Silverberg, Peck Y. Ong, Monica O’Brien, Stephen A. Martin, Peter A. Lio, Mary Laura Lind, Jennifer LeBovidge, Elaine Kim, Joey Huynh, Matthew Greenhawt, Donna D. Gardner, Winfred T. Frazier, Kathy Ellison, Lina Chen, Korey Capozza, Anna De Benedetto, Mark Boguniewicz, Wendy Smith Begolka, Rachel N. Asiniwasis, Lynda C. Schneider, Derek K. Chu

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  • ·Topical treatments for atopic dermatitis (eczema): Systematic review and network meta-analysis of randomized trials

    Pagina :1493-1519

    Derek K. Chu, Alexandro W.L. Chu, Daniel G. Rayner, Gordon H. Guyatt, Juan José Yepes-Nuñez, Luis Gomez-Escobar, Lucia C. Pérez-Herrera, Juan Pablo Díaz Martinez, Romina Brignardello-Petersen, Behnam Sadeghirad, Melanie M. Wong, Renata Ceccacci, Irene X. Zhao, John Basmaji, Margaret MacDonald, Xiajing Chu, Nazmul Islam, Ya Gao, Ariel Izcovich, Rachel N. Asiniwasis, Mark Boguniewicz, Anna De Benedetto, Korey Capozza, Lina Chen, Kathy Ellison, Winfred T. Frazier, Matthew Greenhawt, Joey Huynh, Jennifer LeBovidge, Peter A. Lio, Stephen A. Martin, Monica O’Brien, Peck Y. Ong, Jonathan I. Silverberg, Jonathan M. Spergel, Wendy Smith Begolka, Julie Wang, Kathryn E. Wheeler, Donna D. Gardner, Lynda Schneider

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  • ·IFN-γ–dependent interactions between tissue-intrinsic γδ T cells and tissue-infiltrating CD8 T cells limit allergic contact dermatitis

    Pagina :1520-1540

    Miguel Muñoz-Ruiz, Miriam Llorian, Rocco D'Antuono, Anna Pavlova, Anna Maria Mavrigiannaki, Duncan McKenzie, Bethania García-Cassani, Maria Luisa Iannitto, Yin Wu, Robin Dart, Daniel Davies, Mariam Jamal-Hanjani, Anett Jandke, Dmitry S. Ushakov, Adrian C. Hayday

    Riassunto Riassunto Mappa Mappa   

• Food allergy and gastrointestinal disease

  • ·Gut microbiome is associated with asthma and race in children with food allergy

    Pagina :1541

    Mahboobeh Mahdavinia, John P. Fyolek, Jialing Jiang, Neil Thivalapill, Lucy A. Bilaver, Christopher Warren, Susan Fox, Sai R. Nimmagadda, Pamela J. Newmark, Hemant Sharma, Amal Assa’ad, Patrick C. Seed, Ruchi S. Gupta

    Riassunto Riassunto Mappa Mappa  
  • ·IL-13–induced STAT3-dependent signaling networks regulate esophageal epithelial proliferation in eosinophilic esophagitis

    Pagina :1550-1568

    Sahiti Marella, Ankit Sharma, Varsha Ganesan, Daysha Ferrer-Torres, James W. Krempski, Gila Idelman, Sydney Clark, Zena Nasiri, Simone Vanoni, Chang Zeng, Andrej A. Dlugosz, Haibin Zhou, Shaomeng Wang, Alfred D. Doyle, Benjamin L. Wright, Jason R. Spence, Mirna Chehade, Simon P. Hogan

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  • ·Longitudinal dynamics of the gut microbiome and metabolome in peanut allergy development

    Pagina :1569-1580

    Yoojin Chun, Alexander Grishin, Rebecca Rose, William Zhao, Zoe Arditi, Lingdi Zhang, Robert A. Wood, A. Wesley Burks, Stacie M. Jones, Donald Y.M. Leung, Drew R. Jones, Hugh A. Sampson, Scott H. Sicherer, Supinda Bunyavanich

    Riassunto Riassunto Mappa Mappa   

• Anaphylaxis, drug allergy, urticaria, and angioedema

  • ·United States Drug Allergy Registry (USDAR) grading scale for immediate drug reactions

    Pagina :1581-1586

    David A. Khan, Elizabeth J. Phillips, John J. Accarino, Alexei Gonzalez-Estrada, Iris M. Otani, Allison Ramsey, Anna Chen Arroyo, Aleena Banerji, Timothy Chow, Anne Y. Liu, Cosby A. Stone, Kimberly G. Blumenthal

    Riassunto Riassunto Mappa Mappa
  • ·Pharmacokinetics/pharmacodynamics of epinephrine after single and repeat administration of neffy, EpiPen, and manual intramuscular injection

    Pagina :1587-1596

    Thomas B. Casale, Anne K. Ellis, Anna Nowak-Wegrzyn, Michael Kaliner, Richard Lowenthal, Sarina Tanimoto

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• Mechanisms of allergy/immunology

  • ·The opposing effects of two gene defects in STX11 and SLP76 on the disease in a patient with an inborn error of immunity

    Pagina :1597-1606

    Rana Mansour, Rana El-Hassan, Youmna El-Orfali, Adam Saidu, Habib Al-Kalamouni, Qian Chen, Mehdi Benamar, Ghassan Dbaibo, Rima Hanna-Wakim, Talal A. Chatila, Michel J. Massaad

    Riassunto Riassunto Mappa Mappa  
  • ·Mucosal IgA immune complex induces immunomodulatory responses in allergic airway and intestinal T_H2 disease

    Pagina :1607

    Srikanth Elesela, Llilian Arzola-Martínez, Andrew Rasky, Catherine Ptaschinski, Simon P. Hogan, Nicholas W. Lukacs

    Riassunto Riassunto Mappa Mappa  

• Translational and clinical immunology

  • ·Intestinal microbiome and metabolome signatures in patients with chronic granulomatous disease

    Pagina :1619

    Prabha Chandrasekaran, Yu Han, Christa S. Zerbe, Theo Heller, Suk See DeRavin, Samantha A. Kreuzberg, Beatriz E. Marciano, Yik Siu, Drew R. Jones, Roshini S. Abraham, Michael C. Stephens, Amy M. Tsou, Scott Snapper, Sean Conlan, Poorani Subramanian, Mariam Quinones, Caroline Grou, Virginie Calderon, Clayton Deming, Jennifer W. Leiding, Danielle E. Arnold, Brent R. Logan, Linda M. Griffith, Aleksandra Petrovic, Talal I. Mousallem, Neena Kapoor, Jennifer R. Heimall, Jessie L. Barnum, Malika Kapadia, Nicola Wright, Ahmad Rayes, Sharat Chandra, Larisa A. Broglie, Deepak Chellapandian, Christin L. Deal, Eyal Grunebaum, Stephanie Si Lim, Kanwaldeep Mallhi, Rebecca A. Marsh, Luis Murguia-Favela, Suhag Parikh, Fabien Touzot, Morton J. Cowan, Christopher C. Dvorak, Elie Haddad, Donald B. Kohn, Luigi D. Notarangelo, Sung-Yun Pai, Jennifer M. Puck, Michael A. Pulsipher, Troy R. Torgerson, Elizabeth M. Kang, Harry L. Malech, Julia A. Segre, Clare E. Bryant, Steven M. Holland, Emilia Liana Falcone

    Riassunto Riassunto Mappa Mappa  
  • ·Therapeutic modalities and clinical outcomes in a large cohort with LRBA deficiency and CTLA4 insufficiency

    Pagina :1634-1645

    Nigar Taghizade, Royala Babayeva, Altan Kara, Ibrahim Serhat Karakus, Mehmet Cihangir Catak, Alper Bulutoglu, Zehra Sule Haskologlu, Idil Akay Haci, Ceyda Tunakan Dalgic, Esra Karabiber, Sevgi Bilgic Eltan, Melek Yorgun Altunbas, Asena Pinar Sefer, Ahmet Sezer, Sefika Ilknur Kokcu Karadag, Elif Arik, Zuhal Karali, Aylin Ozhan Kont, Can Tuzer, Sait Karaman, Selver Seda Mersin, Nurhan Kasap, Enes Celik, Dilara Fatma Kocacik Uygun, Sezin Aydemir, Ayca Kiykim, Cigdem Aydogmus, Esra Ozek Yucel, Fatih Celmeli, Emrah Karatay, Emine Bozkurtlar, Semra Demir, Ayse Metin, Neslihan Edeer Karaca, Necil Kutukculer, Guzide Aksu, Sukru Nail Guner, Sevgi Keles, Ismail Reisli, Yasemin Kendir Demirkol, Tugba Arikoglu, Nesrin Gulez, Ferah Genel, Sara Sebnem Kilic, Caner Aytekin, Ozlem Keskin, Alisan Yildiran, Dilek Ozcan, Derya Ufuk Altintas, Fatma Omur Ardeniz, Esin Figen Dogu, Kamile Aydan Ikinciogullari, Elif Karakoc-Aydiner, Ahmet Ozen, Safa Baris

    Riassunto Riassunto Mappa Mappa   
  • ·Maternal vitamin D–related metabolome and offspring risk of asthma outcomes

    Pagina :1646

    Min Kim, Nicklas Brustad, Mina Ali, Gözde Gürdeniz, Morten Arendt, Augusto A. Litonjua, Craig E. Wheelock, Rachel S. Kelly, Yulu Chen, Nicole Prince, Feng Guo, Xiaobo Zhou, Jakob Stokholm, Klaus Bønnelykke, Scott T. Weiss, Hans Bisgaard, Jessica Lasky-Su, Bo Chawes

    Riassunto Riassunto Mappa Mappa  

• Epidemiology and health care delivery

  • ·Fungal allergen sensitization: Prevalence, risk factors, and geographic variation in the United States

    Pagina :1658-1668

    Kenny Kwong, Matthew Robinson, Adam Sullivan, Stanley Letovsky, Andrew H. Liu, Andre Valcour

    Riassunto Riassunto Mappa Mappa   

• Brief reports

  • ·Middle meatus microbiome in patients with eosinophilic chronic rhinosinusitis in a Japanese population

    Pagina :1669

    Masanori Kidoguchi, Yoshimasa Imoto, Emiko Noguchi, Takako Nakamura, Wataru Morii, Naoto Adachi, Rieko Ii, Keisuke Koyama, Satoshi Aoki, Keisuke Miyashita, Yu Hosokawa, Kazuhiro Omura, Yasuhiro Tanaka, Kaori Tanaka, Yukio Hida, Takahiro Ninomiya, Yukinori Kato, Masafumi Sakashita, Tetsuji Takabayashi, Shigeharu Fujieda

    Riassunto Riassunto Mappa Mappa  
  • ·High plasma IL-6 levels may enhance the adverse effects of mouse allergen exposure in urban schools on asthma morbidity in children

    Pagina :1677-1682

    Nicole Akar-Ghibril, Kimberly F. Greco, Medina Jackson-Browne, Wanda Phipatanakul, Perdita Permaul

    Riassunto Riassunto Mappa Mappa  
  • ·Inhaled corticosteroid treatment's impact on asthma exacerbations: Influence of human genetics on microbiome composition

    Pagina :1683

    Yu-Jen Chen, Su-Boon Yong

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  • ·Reply

    Pagina :1683-1685

    Javier Perez-Garcia, Maria Pino-Yanes, Fabian Lorenzo-Diaz

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  • ·Updates in AERD: What is needed further?

    Pagina :1685-1686

    Lucyna Mastalerz, Marek Sanak

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  • ·Reply

    Pagina :1686-1687

    Whitney W. Stevens, Katherine N. Cahill

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  • ·VCD and ILO are not synonymous

    Pagina :1687-1688

    Miles Weinberger

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  • ·Reply

    Pagina :1688-1689

    Paul Leong, James H. Hull, Peter G. Gibson, Thomas Halvorsen, Philip G. Bardin, VCD/ILO Delphi Steering Committee, Anne E. Vertigan, Vanessa M. McDonald, Mark Hew, Malcolm Baxter, Debra Phyland, Thomas L. Carroll, Hege Havstad Clemm, Maria Vollsæter, Ola Drange Røksund

    
  • ·Corrigendum

    Pagina :1690