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• • ·Editorial Board

    Article :118971

    

• Review Articles

  • ·PROTAC delivery systems: Innovative approaches for cancer treatment

    Article :118892

    María Arenas-Moreira, Alberto Ocaña, Iván Bravo, Carlos Alonso-Moreno

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  • ·Dual faces of USP10 in breast cancer: Oncogenic driver, tumor suppressor, and emerging therapeutic target

    Article :118916

    Cong Fan, Jiajia Wang, Jianing Sun, Mengxuan Li, Jiajun Ding, Haoyi Zi, Shuai Wang, Jian Zhang, Ting Wang

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  • ·Hijacking migration: CXCL12-functionalized hydrogels as a new frontier in glioblastoma therapy

    Article :118921

    Hossein Khorramdelazad, Seyed Mahdi Pourtorabi, Mohammad Ghaffarinasab, Zahra Sedghi

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  • ·Gastrointestinal diseases-induced cardiovascular dysfunction: Focus on clinical presentation, pathogenesis and therapeutic implications of gastrocardiac syndrome

    Article :118808

    Wen-Qian Duan, Miao-Miao Guo, Meng-Die Du, Jian Zhang, Shi-Yun Shao, Wen-Shang Fu, Yong-Shun Sun

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  • ·Antimicrobial peptides in cervical carcinogenesis: Dual roles in tumor progression and emerging therapeutic strategies

    Article :118928

    Idalia Błażejczyk, Tamara Daniluk, Kacper Toczyłowski, Joanna Gorbacz-Konończuk, Urszula Wnorowska, Robert Bucki, Ewelina Piktel

    Résumé Résumé Plan Plan  
  • ·Multifaceted role of interleukin-32 in inflammatory diseases and cancer

    Article :118931

    Sun Mi Gu, Yong Sun Lee, Do-Young Yoon, Hye-Moon Kim, Ik Ho Na, Sang-Bae Han, Yoon Seok Roh, Jin Tae Hong

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  • ·Beyond IOP: Neuroprotection and neuroregeneration as important therapeutic strategies for glaucoma

    Article :118833

    Shivani Makhijani, Deepak Khobragade

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  • ·Revolutionizing uveitis treatment with nanotechnology: Innovations, barriers, and strategic solutions

    Article :118911

    MohammadKarim Johari, Roghayyeh Baghban, Raheleh Salari, Alireza Attar

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  • ·Advances in the use of MT1-MMP-targeted nanobodies and peptides for therapeutic delivery in triple-negative breast cancer

    Article :118944

    Parisa Shahmoradipour, Rahman Emamzadeh

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  • ·Descriptive overview of gene variants potentially affecting female infertility treatments: A systematic review

    Article :118942

    Asunta Martinez-Martinez, Francisco José Sanz, Pablo Garcia-Acero, Patricia Sebastian-Leon, Patricia Diaz-Gimeno

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  • ·Proteomics of extracellular vesicles derived from Lactobacillus: Implications in gut immune homeostasis and therapeutic potential

    Article :118955

    Soyeon Lee, Eunbi Jo, Eun-Young Lee, Dongsic Choi

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  • ·Hydrogel-based delivery of cytokines in cancer immunotherapy: Latest evidence and therapeutic outcomes

    Article :118953

    Hossein Khorramdelazad, Ali Pirsadeghi, Elias Amraei, Arash Amani, Mahdieh Abbasnia, Fatemeh Nematzade, Erfan Shahabinejad, Romina Naeinipour Mahabadi, Samin Ghanizadeh, Fateme Sadat Kouchakzade, Samar Monajemi, Marziyeh Mohammadi-Kordkhayli

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  • ·Midkine as a therapeutic node in NF1-driven neuro‑oncology: Biology, biomarkers, and translational strategies

    Article :118947

    Hareesh B. Nair, Ramadevi Subramani, Rajkumar Lakshmanaswamy

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  • ·Protecting the endocrine axis in immuno-oncology: GLP-1 receptor agonists as host-directed modulators in colorectal cancer

    Article :118948

    Samira Saghafi, Mohammad Ali Yaghoubi, Hossein Safarpour, Hamideh Raeisi, Zohreh Mousavi

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• Original Articles

  • ·Protective effect of obeticholic acid on cyclophosphamide-induced thyroid toxicity in rats by inhibiting TXNIP/NLRP3/ASC/caspase-1-dependent pyroptosis and p53/BAX/caspase-3-dependent apoptosis

    Article :118894

    Yasmine F. Ibrahim, Heba K. Alshaeri, Walaa Yehia Abdelzaher, Dina Moustafa Thabit, Ahmed Mohsen Faheem, Sara M. Ahmed

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  • ·Aspartame decreases fat deposits in mice at a cost of mild cardiac hypertrophy and reduced cognitive performance

    Article :118891

    Irati Aiestaran-Zelaia, María Jesús Sánchez-Guisado, Marta Beraza, Libe López-Arandia, Sandra Plaza-García, Irene Fernández-Folgueral, Antonio de Molina-Iracheta, Ian J. Holt, Jesus Ruiz-Cabello

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  • ·Treatment with a botanical mixture of cannabidiol:Δ⁹-tetrahydrocannabinol enhances microglial phagocytosis and shapes amyloid plaques in a mouse model of Alzheimer’s disease

    Article :118902

    Samuel Ruiz de Martín Esteban, M. Teresa Grande, Ana M. Martínez-Relimpio, Diego Herráez-Aguilar, Ricardo Mostany, Cecilia J. Hillard, William H. Hind, Julián Romero

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  • ·A neuroprotective effect of newly isolated probiotic bacterium Lactobacillus acidophilus SLAM_LAA02 in a rotenone-induced mouse model of Parkinson’s disease

    Article :118896

    Yeonsoo Kim, Eunsol Seo, Anna Kang, Min-Geun Kang, Ki Beom Jang, Sangnam Oh, Younghoon Kim

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  • ·Exosome-mediated scutellarin delivery enhances BBB penetration and microglia targeting in antiviral neuroprotection

    Article :118903

    Chunlian Song, Shengjia Sun, Ting Li, Ke Zhang, Xiong Zhao, Zee Zhu, Deng Pan, Huayi Bai, Ying Zhang, Deyan Cui, Limei Yang, Xiaoyu Liu, Xianghua Shu

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  • ·sPLA₂-IIA inhibitor Tricyclic Dipyrido Diazepinone derivative 6 f suppresses poultry organic dust-induced pulmonary inflammation by downregulating ERK1/2-cPLA₂ pathway

    Article :118869

    Deepadarshan Urs, Abdul Rahman, H.S. Shuba, N.D. Satyanarayan, Rajkumar S. Meti, K.K. Dharmappa

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  • ·Doxycycline and IGF-1 as a synergistic combination therapy for OA disease modification

    Article :118897

    Arijit Bhattacharjee, Saptomee Chakraborty, Praganesh Kumar, Dhirendra S. Katti

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  • ·Combination of rosuvastatin and curcumin outperforms monotherapies in alleviating gentamicin-induced nephrotoxicity, audiotoxicity and vestibulotoxicity in a rat animal model

    Article :118753

    Tarik Suljic, Bakir Kudic, Belma Pehlivanovic-Kelle, Aida Hamzic-Mehmedbasic, Jasminka Prguda-Mujic, Jovana Dervovic, Dina Lagumdzija, Jasna Kusturica, Amer Alic, Aida Kulo Cesic

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  • ·Carnosol and melatonin co-treatment attenuates neuroinflammation and oxidative stress in experimental autoimmune encephalomyelitis

    Article :118909

    Maryam Azimzadeh, Morteza Jafarinia

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  • ·Neutralizing endocan reduces blood pressure and improves endothelial function in angiotensin II-induced hypertensive mice

    Article :118910

    Eun Yi Oh, Seonhee Byeon, Soo-Kyoung Choi, Young-Ho Lee

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  • ·NRF2 upregulation by CDDO-Me protects AC16 human cardiomyocytes against doxorubicin-induced toxicity

    Article :118878

    James A. Roberts, Michael Batie, Amy H. Ponsford, Jonathan Poh, Benjamin J. Hewitt, Hannah F. Botfield, Lisa J. Hill, Christopher M. Sanderson, Sonia Rocha, Parveen Sharma

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  • ·Overcoming the undruggable barrier: Structure-guided discovery of a potent small molecule CD28 antagonist with translational potential

    Article :118937

    Saurabh Upadhyay, Hossam Nada, Sungwoo Cho, Moustafa T. Gabr

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  • ·Discovery of novel chalcone derivatives containing benzimidazole possessing anti-tumor potential in vitro and in vivo

    Article :118912

    Qianyu Wang, Hui Qiao, Weixi Yuan, Xiangping Deng, Zhizhong Xie, Xiaoyong Lei, Xiaoyan Yang, Guotao Tang, Zhe Wang

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  • ·Cerebral diffusion of posaconazole in an experimental model of disseminated scedosporiosis

    Article :118918

    Bénédicte Lelièvre, Charlotte Godon, Pierre Legras, Jérémie Riou, David Ternant, Jean-Philippe Bouchara

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  • ·Curcumin-based benzothiazepane analogues exhibit selective anti-cancer activity in HCT-116 cells via precipitated particle formation and internalisation

    Article :118926

    Julie De Munck, Charlotte Grootaert, Katarina Magdalenic, Derya Deveci, Yannick Gansemans, Filip Van Nieuwerburgh, Nico Boon, Andre Skirtach, Andreja Rajkovic, Matthias D’hooghe, John Van Camp

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  • ·Mitochondria-targeted nanosystem-mediated delivery of cryptotanshinone for enhanced suppression of non-small cell lung cancer

    Article :118927

    Qi Zheng, Hanzhou Wang, Yuanchen Zhao, Chao Xue, Rui Liu, Baojin Hua

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  • ·Targeting tumors and inflammation: A quinoline–chalcone ruthenium complex with therapeutic promise

    Article :118930

    Kateřina Veselá, Ameneh Tatar, Zdeněk Kejík, Nikita Abramenko, Jan Čejka, Robert Kaplánek, Michal Masařík, Petr Babula, Pavel Martásek, Milan Jakubek

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  • ·Anti-inflammatory effects of ceragenin CSA-13 in acute pyelonephritis -insights from an animal model

    Article :118929

    Urszula Wnorowska, Ewelina Piktel, Paul B. Savage, Robert Bucki

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  • ·Pharmacological characterization of the anti-nociceptive and anti-inflammatory effects of new CBD-based terpenyl-N-acyl-aryl-hydrazone analogues

    Article :118925

    Carla Gabriely Gaião do Invêncio, Anna Carolina Pereira Lontra, João Pedro Barros de Paiva, Graziella dos Reis Rosa Franco, Isabela Marie Fernandes, Vanessa Silva Gontijo, Catarina Azevedo Ribeiro, Larissa do Nascimento dos Santos, Ana Clara Machado da Silva, Thaís Biondino Sardella Giorno, Sara Manuela Mendonça da Silva Cravo, Maria Emília Sousa, Claudio Viegas Jr., Patrícia Dias Fernandes

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  • ·Metabolic alterations driven by PFKFB3 upregulation confer resistance to trastuzumab in HER2-positive breast cancer

    Article :118898

    Roos Vincken, Samuel T. Pasco, Veronica Steri, Laura Bozal-Basterra, Wilfred F.J. van IJcken, Arkaitz Carracedo, Danny Huylebroeck, Mark M. Moasser, Ana Ruiz-Sáenz

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  • ·Elucidation of mechanisms underlying the therapeutic effects of cordycepin on pulmonary hypertension, with a focus on cell senescence and gut microbiota

    Article :118923

    Gaopeng Li, Zhixin Zhao, Mitsuhiro Machitani, Ryou Ishikawa, Kaori Ishikawa, Naoya Yokota, Reiji Haba, Kazufumi Nakamura, Zhihong Sun, Lin-Hai Kurahara, Katsuya Hirano

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  • ·The binding of the salvianolic acid A to the citrullinating enzyme PADI4 as a potential treatment for cancer

    Article :118935

    Laureano E. Carpio, María Gabriela Álvarez-Rodríguez, David Recio-Moreno, Felipe Hornos, Izabel Georgieva-Nikolova, Ana Camara-Artigas, Virginia Rejas, Miguel Vidal, Martina Palomino-Schätzlein, Camino de Juan Romero, José L. Neira

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  • ·Folate- and aCD47-functionalized lipid nanoparticles efficiently deliver mRNA and remodel pancreatic tumor microenvironment

    Article :118919

    Marta Parés, Javier Martínez-Latorre, Vicente Candela-Noguera, Paula M. Soriano-Teruel, Alba García-Fernández, Víctor Pallaruelo-Santamaría, Elena Aznar, Ramón Martínez-Máñez, Cristina Fillat

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  • ·A potent induction of naked/uridine-unmodified mRNA expression with Jet Injector, Actranza Lab in mouse and rat skins

    Article :118920

    Kazuhiro Terai, Ryusho Kariya, Hiromi Ogata-Aoki, Hiromitsu Iga, Satoshi Sakamoto, Seiji Sakano, Seiji Okada

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  • ·Targeting the underlying immune mechanism of diabetes-induced myocardial dysfunction via modulation of SIRT-3/p53/TIGAR/PFKFB-3 and SIRT-3/NF-κB signaling pathways as a potential controlling strategy

    Article :118901

    Mohamed S. Elsayed, Mahmoud Elshal, Manar G. Helal, Tarek Ibrahim

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  • ·AMP deaminase-2- and adenosine deaminase-mediated disposal of β-cell intracellular adenosine protects against multiple low-dose streptozotocin-induced type 1 diabetes

    Article :118914

    Kailash Singh, Tongjian Zhao, Anongnad Ngamjariyawat, Kina Adjieva, Mudhir Shekha, Ronja Andersson, Averina Octaxena Aslani, Martin Blixt, Zhengkang Luo, Stellan Sandler, Nils Welsh

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  • ·Contribution of the serotonergic system to myopia and the therapeutic effects of atropine and pirenzepine

    Article :118922

    Kate Thomson, Cindy Karouta, Regan Ashby

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  • ·GPRASP1 deletion suppresses antinociceptive tolerance during chronic activation of delta opioid receptor in persistent pain

    Article :118913

    Juliette Kaeffer, Marie-Laure Straub, Glenn-Marie Le Coz, Raphaëlle Quillet, Valérie Kugler, Nathalie Petit-Demoulière, Manon Gerum, Gabrielle Zeder-Lutz, Stéphane Doridot, Michael Dumas, Johana Chicher, Philippe Hammann, Philippe Marin, Franck Vandermoere, Dominique Massotte, Frédéric Simonin, Sandra Lecat

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  • ·Trikafta restores thermodynamic coupling between two nucleotide binding domains for potentiating CFTR activity

    Article :118936

    Guangyu Wang

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  • ·Establishment of a human inner ear model reveals that gentamicin C2b is substantially less ototoxic than clinical gentamicin

    Article :118915

    Minjin Jeong, Hiroaki Mohri, Dongjun Han, Masaharu Sakagami, Konstantina M. Stankovic

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  • ·Chemokine CCL5 overexpression combined with radiotherapy modulates Th1-mediated immune response and leads to significant tumor growth delay in mouse tumor models

    Article :118887

    Tim Bozic, Iva Santek, Ziva Pisljar, Simona Kranjc Brezar, Gregor Sersa, Bostjan Markelc, Maja Cemazar

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  • ·An innovative approach for anti-respiratory syncytial virus compound discovery from plant extracts, combining high-throughput screening and metabolomics

    Article :118917

    Paola Haemmerli, Mathieu Hubert, Arnaud Gaudry, Luis-Manuel Quiros-Guerrero, Florence Mehl, Marco Pagni, Laurence Marcourt, Olivier Auguste Kirchhoffer, Antonio Grondin, Samuel Constant, Song Huang, Emerson Ferreira Queiroz, Sophie Clément, Caroline Tapparel, Jean-Luc Wolfender

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  • ·Glucotropaeolin-enriched Lepidium sativum L. extract as a novel phytotherapy for tendinopathy: mechanistic insights into pain modulation

    Article :118908

    Elena Lucarini, Eleonora Pagnotta, Laura Righetti, Valentina Citi, Samuele Trisolini, Clara Ciampi, Laura Micheli, Alma Martelli, Lara Testai, Vincenzo Calderone, Lorenzo Di Cesare Mannelli, Carla Ghelardini

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  • ·Extracellular vesicles from microalgae as natural bioactive agents for UVB protection, anti-aging, and skin depigmentation

    Article :118961

    Paola Gargano, Sabrina Picciotto, Angela Paterna, Samuele Raccosta, Estella Rao, Daniele Paolo Romancino, Giulia Smeraldi, Mauro Manno, Monica Salamone, Natasa Zarovni, Giorgia Adamo, Antonella Bongiovanni

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  • ·Protective effects of the NAMPT activator P7C3-A20 on mouse neuronal injury in diabetic stroke: The role of intracellular NAMPT and SIRT1/FoxO3a signaling

    Article :118963

    Yui Iwatani, Hideki Hayashi, Mizuki Minamisawa, Shun Hasegawa, Yoshiyuki Moriyama, Norio Takagi

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  • ·Multi-target mechanisms of glabrone in ulcerative colitis: Synergistic restoration of mucosal barrier and inhibition of inflammation through SRC/HSP90 Co-modulation

    Article :118951

    Yamei Li, JunYa Wen, Yuge Wu, Yuxuan Xu, Yufan Wu, Zhuxian Wang, Yiquan Peng, Ming Luo, Hongxia Zhu, Qiang Liu

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  • ·Modeling cancer-associated fibroblast plasticity and breast cancer interactions using patient-derived scaffolds

    Article :118952

    Santiago Ruiz-Martínez, Anna Gustafsson, Elin Johansson, Elena Garre, Khalil Helou, Anders Ståhlberg, Göran Landberg

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  • ·Skin-on-Chip and clinical evaluation of the soothing potential of a topical natural treatment for atopic-prone skin: An exploratory study

    Article :118957

    Ketty Gianesin, Maria Elisabetta Federica Palamà, Elisa Caracciolo, Sonja De Crescenzo, Maurizio Aiello, Fernando Marco Bianchi, Paolo Lucchese, Silvia Scaglione, Emanuele Claudio Cozzani

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• Short Communications

  • ·Amino acid infusion and SGLT2 inhibitors for kidney protection: Plausible adverse impact of tubular transport load on renal tissue oxygenation

    Article :118933

    Samuel N. Heyman, Seymour Rosen, Mayer Brezis, Zaid Abassi

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  • ·An emerging role of CD74 in thyroid follicular cells in Hashimoto´s thyroiditis

    Article :118945

    Pablo Sacristán-Gómez, Ana Serrano-Somavilla, Nuria Sánchez de la Blanca, Andrea Álvarez-Rodríguez, Eduardo Martínez-Parra, Miguel Sampedro-Nuñez, Fernando Sebastián-Valles, Mónica Marazuela, Rebeca Martínez-Hernández

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• Letters to the Editor

  • ·From association to mechanism: Why single-omics biomarker discovery in JIA demands a systems integration paradigm

    Article :118934

    Qiongying Xu, Jiehua Han

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• Corrigendum

  • ·Corrigendum to “Therapeutic potentials of Hibiscus trionum: Antioxidant, anti-lipid peroxidative, hypoglycemic, and hepatoprotective effects in type 1 diabetic rats” [Biomed. Pharmacother. 175 (2024)116630]

    Article :118904

    Sedef Ziyanok-Demirtas