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• • ·Contents

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• • ·Editorial Board

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• • ·Information for Readers

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• Progress in Cardiology

  • ·Current challenges in the evaluation of cardiac safety during drug development: Translational medicine meets the Critical Path Initiative

    Page :317-326

    Jonathan P. Piccini, David J. Whellan, Brian R. Berridge, John K. Finkle, Syril D. Pettit, Norman Stockbridge, Jean-Pierre Valentin, Hugo M. Vargas, Mitchell W. Krucoff, for the CSRC/HESI Writing Group

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• Trial Design

  • ·The Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRA•CER) trial: study design and rationale

    Page :327

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  • ·Evaluation of a novel antiplatelet agent for secondary prevention in patients with a history of atherosclerotic disease: Design and rationale for the Thrombin-Receptor Antagonist in Secondary Prevention of Atherothrombotic Ischemic Events (TRA 2°P)-TIMI 50 trial

    Page :335

    David A. Morrow, Benjamin M. Scirica, Keith A.A. Fox, Gail Berman, John Strony, Enrico Veltri, Marc P. Bonaca, Polly Fish, Carolyn H. McCabe, Eugene Braunwald, for the TRA 2°P-TIMI 50 Investigators d

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  • ·The Cholesterol, Hypertension, and Glucose Education (CHANGE) study for African Americans with diabetes: Study design and methodology

    Page :342-348

    Benjamin J. Powers, Joy L. King, Robin Ali, Aviel Alkon, Lynn Bowlby, David Edelman, Pamela Gentry, Janet M. Grubber, Celine Koropchak, Matthew L. Maciejewski, Felicia McCant, Gwendolyn McKoy, Michael Newell, Eugene Z. Oddone, Maren K. Olsen, Cynthia M. Rose, Gloria Trujillo, Hayden B. Bosworth

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  • ·Rationale and design of the Rural Andhra Pradesh Cardiovascular Prevention Study (RAPCAPS): A factorial, cluster-randomized trial of 2 practical cardiovascular disease prevention strategies developed for rural Andhra Pradesh, India

    Page :349-355

    Clara K. Chow, Rohina Joshi, Arun K. Gottumukkala, Krishnam Raju, Rama Raju, Srinath Reddy, Stephen MacMahon, Bruce Neal

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  • ·Rationale and design for TIME: A phase II, randomized, double-blind, placebo-controlled pilot trial evaluating the safety and effect of timing of administration of bone marrow mononuclear cells after acute myocardial infarction

    Page :356-363

    Jay H. Traverse, Timothy D. Henry, Douglas E. Vaughn, Stephen G. Ellis, Carl J. Pepine, James T. Willerson, David X.M. Zhao, Linda B. Piller, Marc S. Penn, Barry J. Byrne, Emerson C. Perin, Adrian P. Gee, Antonis K. Hatzopoulos, David H. McKenna, John R. Forder, Doris A. Taylor, Christopher R. Cogle, Rachel E. Olson, Beth C. Jorgenson, Shelly L. Sayre, Rachel W. Vojvodic, David J. Gordon, Sonia I. Skarlatos, Lemuel A. Moye', Robert D. Simari, for the Cardiovascular Cell Therapy Research Network (CCTRN)

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  • ·Multicenter randomized study of anticoagulation guided by remote rhythm monitoring in patients with implantable cardioverter-defibrillator and CRT-D devices: Rationale, design, and clinical characteristics of the initially enrolled cohort : The IMPACT study

    Page :364

    John Ip, Albert L. Waldo, Gregory Y.H. Lip, Peter M. Rothwell, David T. Martin, Malcolm M. Bersohn, Wassim K. Choucair, Joseph G. Akar, Mark S. Wathen, Pooyan Rohani, Jonathan L. Halperin, for the IMPACT Investigators

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• Curriculum in Cardiology

  • ·Systematic review of studies of the effect of hyperoxia on coronary blood flow

    Page :371-377

    Hamish Farquhar, Mark Weatherall, Meme Wijesinghe, Kyle Perrin, Anil Ranchord, Mark Simmonds, Richard Beasley

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• Clinical Investigations

  • ·Use of ?-blockers and effects on heart rate and blood pressure post-acute coronary syndromes: Are we on target?

    Page :378-385

    Michael Herman, Jennifer Donovan, Maichi Tran, Brigid McKenna, Joel M. Gore, Robert J. Goldberg, Dennis A. Tighe

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  • ·Detection of myocardial injury in patients with unstable angina using a novel nanoparticle cardiac troponin I assay: Observations from the PROTECT-TIMI 30 Trial

    Page :386-391

    Sean R. Wilson, Marc S. Sabatine, Eugene Braunwald, Sarah Sloan, Sabina A. Murphy, David A. Morrow

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  • ·Validation of the Global Registry of Acute Coronary Event (GRACE) risk score for in-hospital mortality in patients with acute coronary syndrome in Canada

    Page :392-399

    Basem Elbarouni, Shaun G. Goodman, Raymond T. Yan, Robert C. Welsh, Jan M. Kornder, J. Paul DeYoung, Graham C. Wong, Barry Rose, François R. Grondin, Richard Gallo, Mary Tan, Amparo Casanova, Kim A. Eagle, Andrew T. Yan, on behalf of the Canadian Global Registry of Acute Coronary Events (GRACE/GRACE2) Investigators

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  • ·ST-elevation myocardial infarction patients can be enrolled in randomized trials before emergent coronary intervention without sacrificing door-to-balloon time

    Page :400-407

    James C. Blankenship, Kimberly A. Skelding, Thomas D. Scott, Jeremy Buckley, Deborah K. Zimmerman, Amy Temple, Jennifer Sartorius, Enrique Jimenez, Peter B Berger

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  • ·Percutaneous coronary intervention in the Occluded Artery Trial: Procedural success, hazard, and outcomes over 5 years

    Page :408-415

    Christopher E. Buller, Jamie M. Rankin, Ronald G. Carere, Pawel E. Buszman, Matthias E. Pfisterer, Vladimir Dzavik, Boban Thomas, Sandra Forman, Witold Ruzyllo, G.B. John Mancini, Lampros K. Michalis, Pedro F. Abreu, Gervasio A. Lamas, Judith S. Hochman

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  • ·Effect of prasugrel versus clopidogrel on outcomes among patients with acute coronary syndrome undergoing percutaneous coronary intervention without stent implantation: A TRial to assess Improvement in Therapeutic Outcomes by optimizing platelet inhibitioN with prasugrel (TRITON)–Thrombolysis in Myocardial Infarction (TIMI) 38 Substudy

    Page :e21

    Yuri B. Pride, Stephen D. Wiviott, Jacqueline L. Buros, Cafer Zorkun, M. Umer Tariq, Elliott M. Antman, Eugene Braunwald, C. Michael Gibson, for the TIMI Study Group

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  • ·Association between advanced Killip class at presentation and impaired myocardial perfusion among patients with ST-segment elevation myocardial infarction treated with primary angioplasty and adjunctive glycoprotein IIb-IIIa inhibitors

    Page :416-421

    Giuseppe De Luca, C. Michael Gibson, Kurt Huber, Uwe Zeymer, Dariusz Dudek, Donald Cutlip, Francesco Bellandi, Marko Noc, Ayse Emre, Simona Zorman, H. Mesquita Gabriel, Mauro Maioli, Tomasz Rakowski, Mariann Gyöngyösi, Arnoud W.J. van't Hof, on behalf of the EGYPT cooperation

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  • ·Biomarker-guided therapy in chronic heart failure: A meta-analysis of randomized controlled trials

    Page :422-430

    G. Michael Felker, Vic Hasselblad, Adrian F. Hernandez, Christopher M. O'Connor

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  • ·The prognostic importance of modifiable risk factors after heart transplantation

    Page :431-436

    Satish Arora, Pål Aukrust, Arne Andreassen, Svein Simonsen, Einar Gude, Ingelin Grov, Odd Geiran, Arnt Fiane, Lars Gullestad

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  • ·The effects of eplerenone on length of stay and total days of heart failure hospitalization after myocardial infarction in patients with left ventricular systolic dysfunction

    Page :437-443

    Mihai Gheorghiade, Sadiya Khan, John E.A. Blair, Matthew E. Harinstein, Henry Krum, Robin Mukherjee, Bertram Pitt, for the Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival (EPHESUS) Investigators

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  • ·Two-dimensional strain analysis in patients with hypertrophic cardiomyopathy and normal systolic function: A 12-month follow-up study

    Page :444-450

    Ioannis A. Paraskevaidis, Dimitrios Farmakis, Costantinos Papadopoulos, Ignatios Ikonomidis, John Parissis, Aggelos Rigopoulos, Efstathios K. Iliodromitis, Dimitrios Th. Kremastinos

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  • ·Mechanisms of exercise intolerance in patients with hypertrophic cardiomyopathy

    Page :e27

    Vy-Van Le, Marco V. Perez, Matthew T. Wheeler, Jonathan Myers, Ingela Schnittger, Euan A. Ashley

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  • ·Weekend hospital admission and discharge for heart failure: Association with quality of care and clinical outcomes

    Page :451-458

    Tamara B. Horwich, Adrian F. Hernandez, Li Liang, Nancy M. Albert, Kenneth A. LaBresh, Clyde W. Yancy, Gregg C. Fonarow, for the Get With the Guidelines Steering Committee and Hospitals

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  • ·Heart failure disease management program experience in 4,545 heart failure admissions to a community hospital

    Page :459-466

    Antonio Pazin-Filho, Pamela Peitz, Thomas Pianta, Kathryn A. Carson, Stuart D. Russell, Leigh Ebony Boulware, Josef Coresh

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  • ·Prognosis among survivors of primary ventricular fibrillation in the percutaneous coronary intervention era

    Page :467-472

    Jonas S.S.G. de Jong, Roos F. Marsman, José P.S. Henriques, Karel T. Koch, Robbert J. de Winter, Michael W.T. Tanck, Arthur A.M. Wilde, Lukas R.C. Dekker

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  • ·Risk factors and comorbidities associated with obesity in children and adolescents after the arterial switch operation and Ross procedure

    Page :473-479

    Sara K. Pasquali, Bradley S. Marino, Anita Pudusseri, Gil Wernovsky, Stephen M. Paridon, Susan A. Walker, Meryl S. Cohen

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  • ·Current status of cardiac rehabilitation in Latin America and the Caribbean

    Page :480-487

    Yoel Korenfeld, Carlos Mendoza-Bastidas, Leonardo Saavedra, Aura Montero-Gómez, Carmen Perez-Terzic, Randal J. Thomas, Fatima Sert-Kuniyoshi, Julio Vallejos, Rodrigo Ibañez-Arenas, Francisco Lopez-Jimenez

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  • ·B-type natriuretic peptide–guided management and outcome in patients with obesity and dyspnea—Results from the BASEL study

    Page :488-495

    Markus Noveanu, Tobias Breidthardt, Sevgi Cayir, Mihael Potocki, Kirsten Laule, Christian Mueller

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  • ·Are ejection fraction measurements by echocardiography and left ventriculography equivalent?

    Page :496-502

    Samuel W. Joffe, Jarrod Ferrara, Armen Chalian, Dennis A. Tighe, Gerard P. Aurigemma, Robert J. Goldberg

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• Letters to the Editor

  • ·Adding socioeconomic status to Framingham scoring might also improve stroke risk evaluation in young adults with hypertension

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    Oscar M.P. Jolobe

    
  • ·Response to "Adding socioeconomic status to Framingham scoring might also improve stroke risk evaluation in young adults with hypertension"

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    Kevin Fiscella, Daniel Tancredi, Peter Franks

    
  • ·Myocardial infarction in saphenous percutaneous intervention: Are we really doing our best?

    Page :e39

    Iñigo Lozano, Juan Rondan, Pablo Avanzas

    
  • ·Response to "Myocardial infarction in saphenous percutaneous intervention: Are we really doing our best?"

    Page :e41

    Laurent Bonello, Ron Waksman