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• • ·Table of Contents

    Page :i

    
• • ·Editorial Board

    Page :iii

    
• • ·Information for Readers

    Page :v

    

• Results of Expert Meetings

  • ·Drug development for major chronic health conditions—aligning with growing public health needs: Proceedings from a multistakeholder think tank

    Page :23-43

    Konstantin A. Krychtiuk, Tomas LG Andersson, Ulrike Bodesheim, Javed Butler, Lesley H. Curtis, Mitchell Elkind, Adrian F. Hernandez, Christoph Hornik, Gary H. Lyman, Pooja Khatri, Michael Mbagwu, Masahiro Murakami, Gwen Nichols, Lothar Roessig, Anne Quinn Young, Richard L. Schilsky, Neha Pagidipati

    Résumé Résumé Plan Plan  

• Trial Designs

  • ·Rationale and design of the NODE-303 study: evaluating the safety of symptom-prompted, self-administered etripamil for paroxysmal supraventricular tachycardia episodes in real-world settings

    Page :55-61

    James E Ip, Hanh Bui, A John Camm, Benoit Coutu, Peter A. Noseworthy, Maria Leonor Parody, Samuel F Sears, Narendra Singh, Juan Agudelo Uribe, John Vyselaar, Sarah Omodele, Silvia Shardonofsky, David B. Bharucha, Bruce Stambler

    Résumé Résumé Plan Plan   
  • ·TransCatheter aortic valve implantation and fractional flow reserve-guided percutaneous coronary intervention versus conventional surgical aortic valve replacement and coronary bypass grafting for treatment of patients with aortic valve stenosis and multivessel or advanced coronary disease: The transcatheter valve and vessels trial (TCW trial): Design and rationale

    Page :86-94

    Elvin Kedhi, Andi Rroku, Rik S. Hermanides, Jan Henk Dambrink, Sandeep Singh, Jurriën Ten Berg, Dirk-Jan van Ginkel, Martin Hudec, Giovanni Amoroso, Ignacio J. Amat-Santos, Martin Andreas, Rui Campante Teles, Guillaume Bonnet, Eric Van Belle, Lenard Conradi, Leen van Garsse, Wojtek Wojakowski, Vasileious Voudris, Jerzy Sacha, Pavel Cervinka, Erik Lipsic, Samer Somi, Luis Nombela-Franco, Sonja Postma, Kerstin Piayda, Giuseppe De Luca, Krzysztof Malinofski, Thomas Modine

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  • ·Gamification-augmented home-based exercise for peripheral artery disease: Rationale and design of the GAMEPAD Study

    Page :95-102

    Alexander C. Fanaroff, Samantha Coratti, David Farraday, Laurie Norton, Charles Rareshide, Jingsan Zhu, Michael G. Levin, Scott M. Damrauer, Jay S. Giri, Neel P. Chokshi, Benjamin M. Jackson, Mitesh S. Patel

    Résumé Résumé Plan Plan  
  • ·nhancing ifestyles in the etabolic syndrome (ELM) multisite behavioral efficacy trial. Design and baseline cohort

    Page :136-155

    ELM Trial Research Group, Lynda H. Powell, Bryce T. Daniels, Betty M. Drees, Kelly Karavolos, Barbara Lohse, Kevin S Masters, Jacinda M Nicklas, Elizabeth H. Ruder, Sumihiro Suzuki, Nicole Trabold, Laura J. Zimmermann

    Résumé Résumé Plan Plan  

• Clinical Investigations

  • ·Prognostic performance of the IABP-SHOCK II Risk Score among cardiogenic shock subtypes in the critical care cardiology trials network registry

    Page :1-12

    Carlos L. Alviar, Boyangzi K. Li, Norma M. Keller, Erin Bohula-May, Christopher Barnett, David D. Berg, James A. Burke, Sunit-Preet Chaudhry, Lori B. Daniels, Andrew P. DeFilippis, Daniel Gerber, James Horowitz, Jacob C. Jentzer, Praneeth Katrapati, Ellen Keeley, Patrick R. Lawler, Jeong-Gun Park, Shashank S. Sinha, Jeffrey Snell, Michael A. Solomon, Jeffrey Teuteberg, Jason N. Katz, Sean van Diepen, David A. Morrow, CCCTN Investigators

    Résumé Résumé Plan Plan   
  • ·Long-term follow-up of balloon-expandable valves according to the implantation strategy: insight from the DIRECTAVI trial

    Page :13-22

    Nidal Jammoul, Valentin Dupasquier, Mariama Akodad, Pierre-Alain Meunier, Lionel Moulis, Sonia Soltani, Jean-Christophe Macia, Pierre Robert, Laurent Schmutz, Matthieu Steinecker, Christophe Piot, Frederic Targosz, Henri Benkemoun, Benoît Lattuca, François Roubille, Guillaume Cayla, Florence Leclercq

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  • ·Radial artery vs right internal mammary artery as a second conduit during coronary artery bypass grafting

    Page :44-54

    Eishan Ashwat, James A. Brown, Sarah Yousef, Danial Ahmad, Yisi Wang, Floyd W. Thoma, Derek Serna-Gallegos, Pyongsoo Yoon, David West, Danny Chu, Johannes Bonatti, David Kaczorowski, Ibrahim Sultan

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  • ·Variability in guideline-directed medical therapy across sites and operators and long-term mortality and amputation outcomes risk in patients undergoing peripheral vascular interventions

    Page :75-85

    Kim G. Smolderen, Gaëlle Romain, Jacob Cleman, Lindsey Scierka, Carlos Mena-Hurtado

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  • ·Regional differences in outcomes with ablation versus drug therapy for atrial fibrillation: Results from the CABANA trial

    Page :103-116

    Riccardo Cappato, Daniel B. Mark, Adam P. Silverstein, Peter A. Noseworthy, Gianluca Bonitta, Jeanne E. Poole, Jonathan P. Piccini, Tristram D. Bahnson, Melanie R. Daniels, Hussein R. Al-Khalidi, Kerry L. Lee, Douglas L. Packer, CABANA Investigators

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  • ·Should ECG criteria for Low QRS voltage (LQRSV) be specific for Sex?

    Page :117-124

    Jason V Tso, Samuel Montalvo, Jeffrey Christle, David Hadley, Victor Froelicher

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  • ·Dapagliflozin and Blood Pressure in Patients with Chronic Kidney Disease and Albuminuria

    Page :125-135

    Hiddo JL Heerspink, Michele Provenzano, Priya Vart, Niels Jongs, Ricardo Correa-Rotter, Peter Rossing, Patrick B. Mark, Roberto Pecoits-Filho, John JV McMurray, Anna Maria Langkilde, David C. Wheeler, Robert B. Toto, Glenn M. Chertow

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• Research Letters

  • ·Intracoronary electrocardiogram detects coronary microvascular dysfunction and ischemia in patients with no obstructive coronary arteries disease

    Page :62-74

    Erdem Cevik, Ahmet Tas, Zeynep G. Demirtakan, Peter Damman, Yaren Alan, Christopher J. Broyd, Alp Ozcan, Duygu H. Simsek, Mehmet R. Sonsoz, Niels van Royen, Divaka Perera, Justin E. Davies, Sabahattin Umman, Murat Sezer

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  • ·Healthcare utilization and left ventricular ejection fraction distribution in methamphetamine use associated heart failure hospitalizations

    Page :156-160

    Veena Manja, Alexander Tarlochan Singh Sandhu, Steven Asch, Susan Frayne, Mark McGovern, Cheng Chen, Paul Heidenreich

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• Letter to the Editors

  • ·Trial outcome definitions require more attention

    Page :161

    David Füller

    
  • ·LANDMARK trial: Update in study protocol

    Page :162-163

    Akihiro Tobe, Yoshinobu Onuma, Osama Soliman, Andreas Baumbach, Patrick W. Serruys