B-cell compartment abnormalities are associated with ACLF and mortality in patients with liver cirrhosis - 16/06/21
, Camila Matiollo a, c, Carolina Hilgert Jacobsen Pereira b, Janaina Sant’ana Fonseca d, Helder Emmanuel Leite Alves d, Otavio Marcos da Silva d, Vivian de Souza Menegassi d, Leonardo de Lucca Schiavon c, d, Maria Claudia Santos-Silva a, b, e, ⁎ Bienvenue sur EM-consulte, la référence des professionnels de santé.
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| pages | 11 |
| Iconographies | 4 |
| Vidéos | 0 |
| Autres | 0 |
Highlights |
• | B-cell compartment is deeply altered in cirrhotic patients. |
• | Cirrhotic patients with ACLF have increased proportions of double-negative B cells. |
• | Transitional B cells are markedly reduced in patients that died in one year. |
Abstract |
Background |
Liver cirrhosis profoundly affects the immune system, leading to an immunological imbalance known as cirrhosis-associated immune dysfunction.
Aims |
This study aimed to investigate B-cell disturbances in patients with acute decompensation (AD) of cirrhosis and assess relationships with prognosis and mortality.
Methods |
The study included 39 patients with AD of cirrhosis, 29 patients with stable cirrhosis (SC), and 30 healthy controls (CTR). Circulating B-cell subsets and cytokine plasma levels were determined by flow cytometry.
Results |
Cirrhotic groups showed higher percentages of naïve B cells, and lower percentages of CD27+ memory B cells (MBCs) than CTR. Further analysis comparing SC and AD revealed that the latter had higher frequencies of double-negative (DN) B cells and plasmablasts. Patients with more advanced liver disease exhibited a B-cell maturation shift toward MBCs and plasmablasts. Acute-on-chronic liver failure (ACLF) was associated with higher DN frequency. The Kaplan–Meier one-year survival probability was 92.9% in patients with >1.3% of transitional B cells and 27.3% in patients with <1.3%.
Conclusions |
B-cell subsets are markedly altered in cirrhotic patients, and cell profiles differ between stable and decompensated liver disease. Increased frequencies of DN B cells and reduced proportions of transitional B cells may be of great relevance in predicting ACLF and mortality, respectively.
Le texte complet de cet article est disponible en PDF.Abbreviations : CAID, GC, MBCs, NS, CS, AD, SC, PBMC, DN, AUROC, HR, CI, CVID
Keywords : B cells, Immune dysfunction, Liver cirrhosis, Flow cytometry
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Vol 45 - N° 4
Article 101698- juillet 2021 Retour au numéro
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