B-cell compartment abnormalities are associated with ACLF and mortality in patients with liver cirrhosis - 16/06/21
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Highlights |
• | B-cell compartment is deeply altered in cirrhotic patients. |
• | Cirrhotic patients with ACLF have increased proportions of double-negative B cells. |
• | Transitional B cells are markedly reduced in patients that died in one year. |
Abstract |
Background |
Liver cirrhosis profoundly affects the immune system, leading to an immunological imbalance known as cirrhosis-associated immune dysfunction.
Aims |
This study aimed to investigate B-cell disturbances in patients with acute decompensation (AD) of cirrhosis and assess relationships with prognosis and mortality.
Methods |
The study included 39 patients with AD of cirrhosis, 29 patients with stable cirrhosis (SC), and 30 healthy controls (CTR). Circulating B-cell subsets and cytokine plasma levels were determined by flow cytometry.
Results |
Cirrhotic groups showed higher percentages of naïve B cells, and lower percentages of CD27+ memory B cells (MBCs) than CTR. Further analysis comparing SC and AD revealed that the latter had higher frequencies of double-negative (DN) B cells and plasmablasts. Patients with more advanced liver disease exhibited a B-cell maturation shift toward MBCs and plasmablasts. Acute-on-chronic liver failure (ACLF) was associated with higher DN frequency. The Kaplan–Meier one-year survival probability was 92.9% in patients with >1.3% of transitional B cells and 27.3% in patients with <1.3%.
Conclusions |
B-cell subsets are markedly altered in cirrhotic patients, and cell profiles differ between stable and decompensated liver disease. Increased frequencies of DN B cells and reduced proportions of transitional B cells may be of great relevance in predicting ACLF and mortality, respectively.
Le texte complet de cet article est disponible en PDF.Abbreviations : CAID, GC, MBCs, NS, CS, AD, SC, PBMC, DN, AUROC, HR, CI, CVID
Keywords : B cells, Immune dysfunction, Liver cirrhosis, Flow cytometry
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Vol 45 - N° 4
Article 101698- juillet 2021 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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