S'abonner

Post-COVID-19 Immune-Mediated Neurological Complications in Children: An Ambispective Study - 12/10/22

Doi : 10.1016/j.pediatrneurol.2022.06.010 
Lokesh Saini, DM a, , 1 , Deepthi Krishna, MD a, 1, Sarbesh Tiwari, DM b, Jagdish Prasad Goyal, MD a, Prawin Kumar, MD a, Daisy Khera, MD a, Bharat Choudhary, MD a, Siyaram Didel, MD a, Ravisekhar Gadepalli, PhD c, Kuldeep Singh, DM a
a Department of Pediatrics, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India 
b Department of Diagnostic and Interventional Radiology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India 
c Department of Microbiology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India 

Communications should be addressed to: Dr. Saini; Department of Pediatrics; All India Institute of Medical Sciences; Jodhpur, Rajasthan, India.Department of PediatricsAll India Institute of Medical SciencesJodhpurRajasthanIndia

Bienvenue sur EM-consulte, la référence des professionnels de santé.
Article gratuit.

Connectez-vous pour en bénéficier!

Abstract

Background

The neurological manifestation following a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is varied, and till now, only a few studies have reported the same.

Methods

We used retrospective data from May to July 2021 and prospective study data from August to September 2021, including that from children aged between one month and 18 years who presented to a tertiary care referral center with the neurological manifestation and had a history of coronavirus disease 2019 (COVID-19) infection or exposure and positive SARS-CoV-2 serology. The neuroradiological manifestations were further categorized as in a predesigned proforma.

Results

Case records of the 18 children who fulfilled the criteria were included in the study; among them, seven (38.8%) were male and 11 (61.1%) were female. Predominant presentation in our study group was status epilepticus (six of 18) and Guillain-Barré syndrome (five of 18). Other manifestations included stroke (two of 18), demyelinating syndromes (three of 18), and autoimmune encephalitis (two of 18). Most of the children had favorable outcomes except for one mortality in our cohort.

Conclusions

Delayed complications following SARS-CoV-2 infection are seen in children. A temporal correlation was noted between the COVID-19 infection and the increasing number of neurological cases after the second wave. Steroids could be beneficial while treating such patients, especially in the presence of high inflammatory markers. Testing for SARS-CoV-2 serology during the pandemic can give a clue to the underlying etiology. Further multicentric studies are required to understand the varied neurological manifestations following SARS-CoV-2 infection in children.

Le texte complet de cet article est disponible en PDF.

Keywords : COVID-19, Demyelination, Autoimmune, GBS, Status epilepticus, Multiple sclerosis, Seizures


Plan


 Conflict of Interest: None.
 Funding: None.


© 2022  Elsevier Inc. Tous droits réservés.
Ajouter à ma bibliothèque Retirer de ma bibliothèque Imprimer
Export

    Export citations

  • Fichier

  • Contenu

Vol 136

P. 20-27 - novembre 2022 Retour au numéro
Article précédent Article précédent
  • The Long-Term Effectiveness and Safety of Cannabidiol-Enriched Oil in Children With Drug-Resistant Epilepsy
  • Michal Tzadok, Nasrin Hamed, Gali Heimer, Efrat Zohar-Dayan, Shira Rabinowicz, Bruria Ben Zeev
| Article suivant Article suivant
  • Smell and Taste Dysfunction in Pediatric Patients With SARS-CoV-2 Infection
  • Ruth Camila Púa Torrejón, María Victoria Ordoño Saiz, Elena González Alguacil, Marta Furones García, Verónica Cantarín Extremera, María Luz Ruiz Falcó, Víctor Soto Insuga

Bienvenue sur EM-consulte, la référence des professionnels de santé.

Mon compte


Plateformes Elsevier Masson

Déclaration CNIL

EM-CONSULTE.COM est déclaré à la CNIL, déclaration n° 1286925.

En application de la loi nº78-17 du 6 janvier 1978 relative à l'informatique, aux fichiers et aux libertés, vous disposez des droits d'opposition (art.26 de la loi), d'accès (art.34 à 38 de la loi), et de rectification (art.36 de la loi) des données vous concernant. Ainsi, vous pouvez exiger que soient rectifiées, complétées, clarifiées, mises à jour ou effacées les informations vous concernant qui sont inexactes, incomplètes, équivoques, périmées ou dont la collecte ou l'utilisation ou la conservation est interdite.
Les informations personnelles concernant les visiteurs de notre site, y compris leur identité, sont confidentielles.
Le responsable du site s'engage sur l'honneur à respecter les conditions légales de confidentialité applicables en France et à ne pas divulguer ces informations à des tiers.