Optimising detection of thrombosis in paediatric Staphylococcus aureus bacteraemia: A prospective interventional sub-study protocol - 06/02/25

Doi : 10.1016/j.idnow.2024.105010

Keerthi Anpalagan ^a,^b,^⁎ , Asha C. Bowen ^a,^b,^c, Leanne Lamborn ^c, Derek Roebuck ^b,^c, Tina Carter ^b,^c,^m, Jeffrey W. Cannon ^a,^b, Caitlin Symons ^a, Jane McNally ^a,^c, Gillian Woods ^a, Brendan McMullan ^d,^e, Amanda Gwee ^f,^g,^h, Steven Y.C. Tong ^i,^j, Joshua S. Davis ^j,^k,^l, Anita J. Campbell ^a,^b,^c
^a Wesfarmers Centre of Vaccines and Infectious Disease, The Kids Research Institute Australia, Perth, Australia
^b School of Medicine, University of Western Australia, Perth, Australia
^c Perth Children’s Hospital, Perth, Australia
^d Sydney Children’s Hospital, Randwick, New South Wales, Australia
^e School of Clinical Medicine, Faculty of Medicine and Health, UNSW, Sydney Australia
^f The Royal Children’s Hospital Melbourne, 50 Flemington Rd, Parkville, Victoria, Australia
^g Department of Paediatrics, The University of Melbourne, 50 Flemington Rd, Parkville, Victoria, Australia
^h Murdoch Children’s Research Institute, 50 Flemington Rd, Parkville, Victoria, Australia
ⁱ Victorian Infectious Diseases Service, The Royal Melbourne Hospital, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia
^j Department of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia
^k John Hunter Hospital, University of Newcastle, Newcastle, Australia
^l School of Medicine and Public Health, University of Newcastle, Newcastle, Australia
^m Department of Haematology, PathWest, Nedlands, Western Australia, Australia

^⁎Corresponding author at: School of Medicine, University of Western Australia, Australia.School of MedicineUniversity of Western AustraliaAustralia

Highlights

•	Staphylococcus aureus bacteraemia is a serious bloodstream infection, the most common cause of sepsis in children.
•	Deep venous thrombosis has been reported in several retrospective studies and case series in up to 30% of children with S. aureus bacteraemia.
•	Current guidelines do not include imaging to detect thrombosis in children with S. aureus bacteraemia.
•	This pilot prospective interventional study is the first to investigate the proportion of thrombosis in children with S. aureus bacteraemia.

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Abstract

Introduction

Staphylococcus aureus bacteraemia (SAB) is the most common cause of sepsis, contributing to paediatric intensive care unit admission in Australia and New Zealand. While deep venous thrombosis (DVT) has been reported in children with invasive S. aureus infections, the actual frequency and possible effects of thrombosis on disease severity and outcome in paediatric SAB remain unknown. Moreover, guidance regarding imaging for paediatric SAB management are poorly defined.

Methods and analysis

We report the protocol for the SNOOPY (Staphylococcus aureus Network; ultrasOund for diagnOsis of endovascular disease in Paediatrics and Youth) study. SNOOPY is a pilot prospective single-arm interventional study that aims to investigate the proportion of children with SAB that have venous thrombosis detected using whole body doppler ultrasound.

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Keywords : Staphylococcus aureus bacteraemia, Thrombosis, Prospective cohort study, Paediatrics

Abbreviations : CVC, CI, DUS, DVT, SAB

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Vol 55 - N° 1

Article 105010- février 2025 Retour au numéro

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Optimising detection of thrombosis in paediatric Staphylococcus aureus bacteraemia: A prospective interventional sub-study protocol - 06/02/25

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