Does giving magnesium sulphate to the mother during labour reduce the risk of cerebral palsy or death in premature babies?
Double blind randomised controlled trial.
Magnesium sulphate lowered, but did not significantly reduce, the risk of death or cerebral palsy compared with placebo (see Table 1). Magnesium sulphate significantly reduced the risk of substantial motor dysfunction compared with placebo. There were no major adverse effects in the mother, although minor adverse events were more frequent with magnesium sulphate compared with placebo (RR 2.74, 95% CI 1.81 to 4.15).
Magnesium sulphate provides some protection against nerve damage in premature babies and should be investigated in future trials.Le texte complet de cet article est disponible en PDF.
Keywords : Magnesium sulphate, Premature labour, Cerebral palsy, Neuroprotective agents,Randomised controlled trial
| Abstracted from: Crowther CA, Hiller JE, Doyle LW et al. Effect of magnesium sulfate given for neuroprotection before preterm birth. A randomized controlled trial. JAMA 2003; 290: 2669–2676.