Challenges and opportunities for improving the druggability of natural product: Why need drug delivery system? - 17/06/23
, Weilie Xiao a, b, c, d, ⁎ Abstract |
Bioactive natural products (BNPs) are the marrow of medicinal plants, which are the secondary metabolites of organisms and have been the most famous drug discovery database. Bioactive natural products are famous for their enormous number and great safety in medical applications. However, BNPs are troubled by their poor druggability compared with synthesis drugs and are challenged as medicine (only a few BNPs are applied in clinical settings). In order to find a reasonable solution to improving the druggability of BNPs, this review summarizes their bioactive nature based on the enormous pharmacological research and tries to explain the reasons for the poor druggability of BNPs. And then focused on the boosting research on BNPs loaded drug delivery systems, this review further concludes the advantages of drug delivery systems on the druggability improvement of BNPs from the perspective of their bioactive nature, discusses why BNPs need drug delivery systems, and predicts the next direction.
Il testo completo di questo articolo è disponibile in PDF.Highlights |
• | The universal bioactivity characteristics of BNPs are firstly summarized. |
• | The druggability enhancement pathways of BNPs by DDSs is discussed. |
• | The current integration between BNPs and DDSs are comprehensively discussed. |
Abbreviations : BNPs, DDSs, VEGFR, PKB or Akt, NRFB, AMPK, MAPK, COX, LOX, TGF, MARCH 1, AD, Aβ, APP, HCC, iNOS, HIV-1, p53, ROS, NF-κB, ER, CD, TNF-α, PIP2, PIP3, HO-1, Keap1, ARE, ERK, FOXO, SIRT1, MAP2K, PDK1, SOD, CAT, GPx, ATM, CXCL-1/2, DI-1, SMA, MMP-2, P-gp, TAK1, mTOR, mTORC2, P70S6K, HSF1, PTEN, PI3K, TAMs, CIP2A, Bcl-2, HSF, miR-21, DYRK2, PKC δ, cAMP, DKK-3, PGC1α, TF, TFEB, STAT, mSIN1, GβL, NRF2, IFN-γ, IL, EGCG, DHA, PTX, MOFs, ZIF-8, RES, AUC, PEG, SB, HA, RBPR, BBR, QUE, CPT, DOX, UV, NIR, CAFS, TME, MRI, CT, PET/CT, PAI, Bax, HSPs, PB, FUS, MW, PC, ICG, PFA, PUA, GSH, AIE
Keywords : Bioactive natural product, Bioactive nature, Multi-targets, Druggability, Drug delivery system, Combination
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Vol 164
Articolo 114955- agosto 2023 Ritorno al numero
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