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• • ·Editorial Board

    Article :118575

    

• Review Articles

  • ·Engineered extracellular vesicles in female reproductive and pregnancy-related disorders

    Article :118453

    Linlin Wang, Wenting Cao, Lichun He, Songchen Cai, Dongyong Yang, Gang Feng, Xian Chen, Udo R. Markert, Lianghui Diao

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  • ·Frontier technologies for investigating endothelial heterogeneity and function in diabetic vascular disease: An updated review

    Article :118445

    Huifang Guan, Shuang Zhao, Xinyi Fang, Runyu Miao, Yanjiao Zhang, Yuxin Zhang, Jiaxing Tian

    Résumé Résumé Plan Plan  
  • ·Mechanism of actions of probiotics on type 2 diabetes: Development and complications

    Article :118421

    Duygu Ağagündüz, Elif Çelik, Özge Cemali, Ozge Yesildemir, Kezban Şahin Demirci, Gamze Akkus, Tuba Esatbeyoglu, Fatih Ozogul

    Résumé Résumé Plan Plan  
  • ·The significance of dysregulated serine metabolism in depression

    Article :118458

    Lilin Yan, Mengna Lv, Cheng Zhao, Jin Pei, Mingmei Zhou

    Résumé Résumé Plan Plan  
  • ·Bacoside-A from Bacopa monnieri (L.) Wettst.: Molecular targets, preclinical insights, and therapeutic potential in type 2 diabetes mellitus and neurodegeneration

    Article :118466

    Abhishek Dadhich, Yoshita Sharma, Abhishek kumar Verma, Rajeev Nema, Madan Mohan Sharma

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  • ·MicroRNA-128–3p as a promising target in neuropsychiatric disorders: From epigenetics to pharmacological intervention

    Article :118452

    Anuj K. Verma, Yu Funahashi, Bhaskar Roy, Yogesh Dwivedi

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  • ·The role of MMPs and TIMPs in regenerative medicine: From pathological ECM remodeling to therapeutic applications

    Article :118457

    Arya Kazemi, Mobin Fathy, Ali Jahanian, Javad Khanali, Yasamin Ostadi, Amirhesam Babajani, Tahereh Tayebi, Hassan Niknejad

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  • ·The two faces of blue light: From treating inflammation to causing oxidative stress in the skin

    Article :118442

    Aleksandra Werner, Anna Erkiert-Polguj, Elzbieta Budzisz

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  • ·Cytotoxic agents for electrochemotherapy: Efficacy, mechanisms of action, potential candidates

    Article :118451

    Arnoldas Morozas, Veronika Malyško-Ptašinskė, Aušra Nemeikaitė-Čėnienė, Julita Kulbacka, Nina Rembiałkowska, Justinas Ivaška, Vitalij Novickij

    Résumé Résumé Plan Plan   
  • ·The emerging role of miR-22 in inflammation

    Article :118482

    Jiajia Du, Liang Cao, Jiajun Zhou, Zhendong Liao, Bo Hu, Ke Zhou, Hongyu Li, Jiajie Tu, Jianjun Liu

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  • ·Therapeutic applications of alpha-lipoic acid: A review of clinical and preclinical evidence (1998–2024)

    Article :118480

    Bianca Leite Carnib, Emilly V. Souza, Luciana R.S. Floresta, Tamiris Marques Lage, Irma Danielle Rodrigues Pedro, Fernando César Muniz, Anielle Christine A. Silva, Jerusa Maria Oliveira

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  • ·Three-dimensional preclinical models for Osteosarcoma: Advances and translational prospects

    Article :118471

    Aurora Puce, Virginia Ferraresi, Roberto Biagini, Silvia Soddu, Rossella Loria

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  • ·Innovative therapies for diabetic foot ulcers: Application and prospects of smart dressings

    Article :118498

    Xue Zhao, Yang Zhang, Zhonglu Huang, Xueping Wu, Jian Lin

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  • ·Interactions between astrocytes and cerebral endothelial cells in central nervous system diseases

    Article :118516

    Jing Sun, Zhidong He

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  • ·Plasma rich in growth factors as a treatment for ocular fundus diseases: Mapping current applications and future directions

    Article :118440

    Eduardo Anitua, Iraia Reparaz, Mohammad H. Alkhraisat

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  • ·The molecular mechanisms of disulfidptosis and its role in Diabetes mellitus and its complications

    Article :118499

    Yang Zhang, Qing Ni, YuPeng Chen, Zhenzhen Pei, Xinyao Xu

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  • ·An insight review on the potential anti-hypertensive effects of Moringa oleifera

    Article :118500

    Wasim S.M. Qadi, Nini Tasnim Fadzel, Ahmed Mediani, Murni Nazira Sarian, Xiaohui Tong, Rongchun Han, Faidruz Azura Jam, Zulzikry Hafiz Abu Bakar, Hamizah Shahirah Hamezah

    Résumé Résumé Plan Plan  
  • ·Effects of nutrients and diet on mitochondrial dysfunction: An opportunity for therapeutic approaches in human disease

    Article :118493

    Lisa H. Do, Renata T. Da Costa, Maria E. Solesio

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  • ·Transcriptional dysregulation of skin barrier genes in atopic dermatitis and psoriasis: Mechanistic insights and emerging therapeutic strategies

    Article :118508

    Yang Che-Wen, Feng-Ling Lin, Kun-Hung Chen, Yu-Ping Cheng, Yu-Che Cheng, Jiun-Wen Guo

    Résumé Résumé Plan Plan   
  • ·Innovations in cancer immunotherapy with PD-1 antibody-drug conjugates and their antitumor mechanisms

    Article :118517

    Jianwei Wang, Zeyu Chen, Yanling Wu, Wen Zhang, Annoor Awadasseid

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  • ·From basics to clinics: New opportunities for metformin in tumor metabolic intervention and treatment

    Article :118507

    Huiying Lv, Haofei Gong, Ran Zhao, Xuan Gao, Wenyue Liu, Lijun Zhao, Ruili Sun

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  • ·Carotenoids as neuroprotective agents in multiple sclerosis: Pathways, mechanisms, and clinical prospects

    Article :118496

    Elham Nadimi, Shirin Jamal Omidi, Mahshad Ghasemi, Mohammad Hashem Hashempur, Aida Iraji

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  • ·Bacterial exopolysaccharides and live biotherapeutics: Orchestrating immune modulation and therapeutic potential in the gut microbiome era

    Article :118510

    Arpit Shukla, Mark Tangney

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  • ·Viral oncogenesis and immune remodeling: Decoding the therapeutic potential of immune checkpoint inhibitors in virus-associated cancers

    Article :118515

    Lihua Qi, Bai Hu, Canhui Cao, Ting Peng, Miaochun Xu, Shiyi Liu, Yashi Xu, Xiaojie Liu, Wencheng Ding, Li Li, Shitong Lin

    Résumé Résumé Plan Plan  
  • ·Autophagy in colorectal cancer: Current understanding of mechanisms and future therapeutic directions

    Article :118524

    Zhaoxia Qu, Xinhui Pen, Youbin Liu, Xiaozhen Pen, Xingjun Lu, Shunli Luo

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  • ·A Scoping Review of Chemical, Pharmacological and Toxicological Properties and Clinical Applications of Australian Indigenous Medicine

    Article :118503

    Kayla Jaye, Indeewarie Hemamali Dissanayake, Deep Jyoti Bhuyan, Dennis Chang

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  • ·Phenylketonuria: A guide through the complex maze of its neurological pathophysiology providing a new perspective on treatment strategies

    Article :118522

    Ine Nulmans, Sien Lequeue, Liesbeth Desmet, Gigly G. Del’haye, Nina S. Salvi, Matthias Rombaut, Jessie Neuckermans, Joery De Kock

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  • ·Physiological functions and structural features of Gα12/13 proteins

    Article :118523

    Sabriye Aydoğdu, Anna Pepanian, Dhruv C. Rathod, Felina Schulz, Diana Imhof

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  • ·Targeting protein misfolding in Alzheimer’s disease: The emerging role of molecular chaperones

    Article :118531

    Anushka Sharma, Shriyansh Srivastava, Pranav Gupta, Sathvik Belagodu Sridhar, Mohd. Tariq, G.S.N. Koteswara Rao, Sachin Kumar, Tabarak Malik

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  • ·The pathogenesis of immune-mediated necrotizing myopathy: Progress and therapeutic implications

    Article :118525

    Mengge Yang, Zhuajin Bi, Zhijun Li, Jiayang Zhan, Huajie Gao, Qing Zhang, Zhouping Tang, Bitao Bu

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  • ·The dual role of VDAC in cancer: Molecular mechanisms and advances in targeted therapy

    Article :118530

    Hongxia Huang, Min Chen, Shubing Feng, Zhenhong Lin, Yuanhang Liu

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  • ·Harnessing nanotechnology to modulate hypoxic tumor microenvironments: Enhanced strategies for oncological innovations

    Article :118543

    Vahid Ghassemifar, Azin Zahedi, Mohammad Saeed Soleimani Meigoli, Tahere Mokhtari, Seyedeh Sahar Mojtaba Zadeh, Mahdis Parsafar, Masoumeh Kaveh Zenjanab, Rana Jahanban Esfahlan

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  • ·Innovative nanotechnology for infectious and inflammatory disease control: From diagnostics to therapeutics

    Article :118551

    Fatemeh Khosravi, Parham Rahmani, Rana Jahanban Esfahlan

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  • ·Angiogenesis in the ovary – Proangiogenic factors and their clinical applications

    Article :118416

    Hanna Jankowska-Ziemak, Magdalena Kulus, Kornelia Krajnik, Jakub Kulus, Mikołaj Chwarzyński, Marcin Ciorga, Michał Gnus, Aleksandra Górska, Krzysztof Data, Dominika Domagała, Julia Niebora, Teresa Wysocka, Marek Spaczyński, Dorota Bukowska, Paweł Antosik, Piotr Dzięgiel, Paul Mozdziak, Bartosz Kempisty

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• Original Articles

  • ·Towards development of Nav1.7 channel modulators for pain treatment: A comparison of mexiletine effect in two cell models by automated patch clamp

    Article :118450

    Alessandro Giovanni Cerchiara, Manuel Marinelli, Brigida Boccanegra, Michela De Bellis, Niels Fertig, Nadine Becker, Alison Obergrussberger, Paola Imbrici, Annamaria De Luca

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  • ·Amentoflavone inhibits colorectal tumor growth, stemness, and metastasis, prolonging survival through GLI-1/IL6/STAT3 axis targeting

    Article :118435

    Yi-Jen Fang, Cheng-Hsien Chen, Hsiang-Ju Ku, Dai-Cheng Dong, Tsai-Lan Liao, Fei-Ting Hsu

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  • ·Soluble guanylate cyclase stimulation improves cardiac function and mitochondrial activity in a rat model of early-stage heart failure with preserved ejection fraction

    Article :118439

    Xocas Vázquez-Abuín, Sandra Moraña-Fernández, Alana Aragón-Herrera, Peter Sandner, Karen Thomitzek, Javier García-Seara, Susana B. Bravo, Manuel Otero-Santiago, Pablo de la Fuente-López, Carlos Tilves-Bellas, Alexandre Rodrigues, Alexandre Gonçalves, Juliana Pereira Morais, Inês N. Alves, Cláudia Sousa-Mendes, Inês Falcão-Pires, Estefanía Tarazón, Esther Roselló-Lletí, Manuel Portolés, Oreste Gualillo, José Ramón González-Juanatey, Sandra Feijóo-Bandín, Francisca Lago

    Résumé Résumé Plan Plan   
  • ·Reprogramming macrophage polarization with a small molecule G3I: Enhancing tumor suppression and inflammation control

    Article :118448

    Chaelin Lee, Kewon Kim, Soonsil Hyun, Sungwoo Hong, Inmoo Rhee

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  • ·The repurposed STAT3 inhibitor pyrimethamine controls mycobacterial infection-induced vascular permeability and mycobacterial burden

    Article :118464

    Darryl JY Han, Xiangyu Sui, Sakshi Agarwal, Ria Sorayah, Amit Singhal, Luke H. Hoeppner, Stefan H. Oehlers

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  • ·Isorhamnetin protects melanocytes against CD8+ T cell-mediated apoptosis and reduces inflammation in vitiligo-afflicted mouse

    Article :118456

    Wen Hu, Hongjuan Wang, Zixian Lei, Kaixiao Li, Yima Na, Xiaojing Kang

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  • ·New insights into thiopurine toxicity: The contribution of rare XDH variants to myelotoxicity

    Article :118446

    Hugo Tejera-Pérez, Alejandro Velasco-Ruiz, María Chaparro, Rocío Núñez-Torres, Guillermo Pita, M. Rosario Alonso, Belén Herráez, Nuria Álvarez, Carla Cortina-Martin, Pilar Puig-Serra, Raúl Torres-Ruiz, Sandra Rodriguez-Perales, Elena Ricart, Miriam Mañosa, Lucía Márquez, M.Dolores Martín-Arranz, Yamile Zabana, Jordi Guardiola, Antonio Giordano, Marta Piqueras, Eva Iglesias, Xavier Calvet, Alfredo J. Lucendo, David Busquets, Ingrid Ordás, Margalida Calafat, Eugeni Domènech, Javier P. Gisbert, Anna Gonzalez-Neira, on behalf of the ENEIDA Project of GETECCU

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  • ·Hydroxypropyl-Beta-Cyclodextrin (HP-BCD) inhibits SARS-CoV-2 replication by modulating intracellular lipid dynamics and preventing viral replication complex formation

    Article :118465

    Bruno Braz Bezerra, Keylla Vitória Gomes Macedo, Isadora Alonso Correa, Sharton Vinicius Antunes Coelho, Marcos Romario Matos de Souza, Barbara Martins Cordeiro, Carlos Frederico Leite Fontes, Fabiana Avila Carneiro, Flavio Matassoli, Luciana Jesus Costa, James E.K. Hildreth, Luciana Barros Arruda

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  • ·Synergistic apoptotic effects of berberine and hesperidin co-encapsulated in PLGA nanoparticles on lymph node carcinoma of prostate cell line

    Article :118455

    Mohammadreza Ramezanimoladehi, Sanaz Sheikhzadeh, Nowruz Delirezh

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  • ·Carnosol modulates mPGES-1/PPAR-γ biological axis: from in silico to in vivo clinical imaging and investigations

    Article :118407

    Erica Gazzillo, Anella Saviano, Federica Raucci, Gian Marco Casillo, Marina Russo, Maria Donniacuo, Vittorio Patanè, Francesca Iacobellis, Gianluigi Lauro, Stefania Terracciano, Maria Chiara Brunese, Ines Bruno, Maria Giovanna Chini, Barbara Rinaldi, Alfonso Reginelli, Salvatore Cappabianca, Francesco Maione, Giuseppe Bifulco

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  • ·Sex-specific glomerular filtration rate changes in response to acute hemoglobin exposure

    Article :118461

    Daniela Lucas, Cynthia R. Muller, Carlos Munoz, Quintin O’Boyle, Andre F. Palmer, Pedro Cabrales

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  • ·Polypharmacological effects of honokiol on allergic rhinitis: Modulation of TMEM16A, TRPV1, and calcium signaling

    Article :118460

    Hong Thi Lam Phan, Yu-Ran Nam, Hyun Jong Kim, Nhung Thi Hong Van, Ngoi Thi Vo, Joohan Woo, Jintae Kim, Joo Hyun Nam, Woo Kyung Kim

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  • ·Cannabigerol attenuates liver fibrosis via AMPK activation: Regulation of lipid metabolism, inflammation, and hepatic stellate cell activation

    Article :118463

    Kyung-Hwa Jeon, Seojeong Kim, Seojeong Park, Eun Seon Pak, Soomin Kim, Hwa Jong Lee, Tae Hyung Kim, Jun Jie Piao, Dongho Shin, Woong Jin Bae, Sae Woong Kim, Youngjoo Kwon

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  • ·Unravelling drug-induced hepatic steatosis: Clinical sub-phenotypes, outcome prediction, and identification of high-concern drugs and hazardous chemical attributes

    Article :118459

    Marta Moreno-Torres, Ernesto López-Pascual, Erika Moro, Anna Rapisarda, Birgitte Lindeman, Anouk Verhoeven, Thomas Luechtefeld, Eva Serrano-Candelas, Hubert Dirven, Mathieu Vinken, José V. Castell, Ramiro Jover

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  • ·Image based subcellular mapping of the protein landscape of SARS-CoV-2 infected cells for target-centric drug repurposing

    Article :118447

    Marianna Tampere, Trang H. Le, Elin Asp, Adelinn Kalman, Jayasankar Mohanakrishnan Kaimal, Duncan Njenda, Anna Bäckström, Ulrika Axelsson, Hao Xu, Wei Ouyang, Hanna Axelsson, Francesco Marabita, Elisabeth Moussaud-Lamodière, Carolina Oses Sepulveda, Brinton Seashore-Ludlow, Caroline Vernersson, Ali Mirazimi, Emma Lundberg, Päivi Östling, Charlotte Stadler

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  • ·Tailoring curcumin-loaded PLGA electrospun nanofibers for anti-cancer treatment via different delivery routes and for potential post-tumor removal implantation

    Article :118444

    Fatemeh Ajalloueian, Atena Malakpour-Permlid, Marzieh Yeganegi, Somayeh Azizi, Aleka Vasos, Gohar Soufi, Anja Boisen

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  • ·Ginkgolide A enhances cognition and reduces amyloid-β by activating autophagy in the murine 5xFAD Alzheimer’s disease model

    Article :118472

    Subin Park, Miey Park, Hae-Jeung Lee

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  • ·Multimodal single-cell transcriptomics with patient-specific iPSC-derived airway organoids as a drug screening approach for cystic fibrosis with nonsense mutations

    Article :118476

    Ping-Hsing Tsai, Yi-Ping Yang, Chia-Hao Wang, Kung-Hao Liang, Chih-Ling Yeh, Tzu-Yu Huang, Tzyh-Chang Hwang, Wen-Liang Lo, Yuan-Tzu Lan, Lo-Jei Ching, Mong-Lien Wang, Teh-Ia Huo, Yung-Hung Luo, Shih-Hwa Chiou, Shih-Jie Chou

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  • ·Age- and sex-associated effects of C18 ceramide sphingolipids on osteoclastogenesis in experimental models of Gulf War Illness

    Article :118418

    Chiaki Yamada, Amilia Nusbaum, Natasha Sanz, Hawra AlQallaf, Benjamin A. Cameron, Lubov Nathanson, Clark T. Barco, Nancy Klimas, Alexandru Movila

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  • ·The novel Bruton tyrosine kinase inhibitor branebrutinib abrogates lipopolysaccharide/galactosamine-induced hepatic injury via limiting inflammation and oxidative stress

    Article :118462

    Mohamed E. Shaker, Ahmed A. Shaaban, Hesham A.M. Gomaa, Mohamed A. Abdelgawad, Mohamed El-Mesery, Sara H. Hazem

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  • ·Autism spectrum disorders and nutritional interventions: dimethylglycine and B‐vitamins effects on behaviour, inflammation, microbiota and mitochondria in liver and brain synapses

    Article :118477

    Fabiano Cimmino, Lidia Petrella, Claudia Cristiano, Gina Cavaliere, Eduardo Penna, Amelia Pizzella, Claudio Pirozzi, Chiara Fogliano, Lorena Coretti, Francesca Lembo, Roberto Berni Canani, Bice Avallone, Marianna Crispino, Giovanna Trinchese, Maria Pina Mollica

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  • ·Synergistic enhancement of anticancer effects by periodontal ligament stem cell exosomes and oxaliplatin via apoptosis induction and protein modulation

    Article :118481

    Jarunya Ngamkham, Wararat Chiangjong, Pei-Wen Wang, Dar-Bin Shieh, Thainsang Phansri, Hathaitip Sritanaudomchai

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  • ·Immunomodulatory effects of phthiocol: An aryl hydrocarbon receptor ligand regulating conventional dendritic cells and macrophages to alleviate sepsis and lupus severity

    Article :118475

    Areerat Kunanopparat, Warerat Kaewduangduen, Promchat Chareanpat, Asada Leelahavanichkul, Amanee Samaeng, Chonlada Chaiwichit, Nattakan Ariyaraphong, Tanapat Palaga, Patcharee Ritprajak

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  • ·Antidepressant-like actions of lanifibranor and its related mechanisms in mouse models of depression: Involvement of hippocampal PPARα and BDNF

    Article :118406

    Pei-Juan Wang, Hua Fan, Bo Jiang, Jia-Jia Shi, Xiang-Ming Cai, Lei Ji, Qi Yan, Chao Liu

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  • ·A novel quinoid-based CDC25 phosphatase inhibitor against human lung adenocarcinoma across different models

    Article :118470

    Tsung‑Ching Lai, Iin Narwanti, Bidyadhar Sethy, Ching Han Tsai, Ayushi Sharma, Jer‑Hwa Chang, Jing-Ping Liou, Yi-Min Liu, Ming-Hsien Chien

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  • ·Niosomal hesperidin ameliorates depression-induced behavioral, histological, and molecular alterations in the rat hippocampus

    Article :118473

    Mahsa Otarkhani, Homeira Hatami, Yousef panahi, Abdallah Al Jammal, Reihaneh Sadeghian, Sama Yavari

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  • ·PEPITEM and its tripeptide pharmacophores: Mechanisms of bone regulation and therapeutic potential in health and disease

    Article :118489

    Kathryn Frost, Alyssa Urbanowski, Georgiana Neag, Jonathan W. Lewis, Ellie Northall, Samuel Kemble, Emily Powell, Adam P. Croft, Asif J. Iqbal, G. Ed Rainger, James R. Edwards, Amy J. Naylor, Helen M. McGettrick

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  • ·JS-K enhances renal cell carcinoma radiosensitivity through the Wnt/β-catenin signaling pathway and inhibits DNA damage repair

    Article :118514

    Yuwan Zhao, Xinghua Lin, Wenfeng Zeng, Lugang Zhu, Bailiang Miu, Xingzhang Qin, Sheng Gao, Jingping Qiu, Bin Li, Jianjun Liu, Mushi Ye

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  • ·The metal-organic framework MIL-100(Fe) and ferric citrate as potential counteracting biomaterials against osteoarthritis-induced articular inflammation and fibrosis

    Article :118519

    Pei-Shiue Tsai, Kevin C.-W. Wu, Ching-Ho Wu

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  • ·Synergistic alleviation of obesity and associated cardiovascular complications by combined modulation of FASN/Arginase/eNOS uncoupling

    Article :118486

    Ebtesam Ahmed Sabry, Mahmoud H. Elbatreek, Hany M. El-Basossy, Noura A. Hassan

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  • ·Trastuzumab cardiotoxicity and drug cardioprotection in healthy and cardiac dysfunction mouse models

    Article :118490

    Serena L’Abbate, Matilde Masini, Giuseppina Nicolini, Sabrina Marchetti, Francesca Forini, Iacopo Fabiani, Giuseppe Vergaro, Vincenzo De Tata, Michele Emdin, Claudia Kusmic

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  • ·Mn(III)-porphyrins in battle against neurodegenerative and cancer diseases

    Article :118488

    Ladislav Šoltés, Jürgen Arnhold, Peter Rapta, Matúš Šedivý, Petr Neugebauer, Svetlana Hrouzková, Agneša Szarka, Mojmír Mach, Katarína Valachová

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  • ·Empagliflozin reduces left ventricular mass increase and improves cardiomyocyte hypertrophy after 5/6 nephrectomy

    Article :118497

    Xin Chen, Christian T. Wohnhaas, Denis Delić, Nicolas Schommer, Daniel Duerschmied, Yaochen Cao, Zeyu Zhang, Christoph Reichetzeder, Mohamed M.S. Gaballa, Bernhard K. Krämer, Thomas Klein, Ben He, Linghong Shen, Berthold Hocher

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  • ·Phase I study of intraperitoneal irinotecan with systemic capecitabine and oxaliplatin for patients with gastric peritoneal metastases

    Article :118491

    Niels A.D. Guchelaar, Marion W. Tops-Welten, Pieter C. van der Sluis, Bo J. Noordman, Stijn L.W. Koolen, Sjoerd M. Lagarde, Grard A.P. Nieuwenhuijzen, Micha J. de Neijs, Irene E.G. van Hellemond, Misha D.P. Luyer, Geert-Jan Creemers, Ignace H.J.T. De Hingh, Bianca Mostert, Bas P.L. Wijnhoven, Ron H.J. Mathijssen

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  • ·A novel method for generating chimeric antigen receptor-transduced primary human natural killer cells by the use of multiple cytokines and anti-CD2 and anti-NKp46 stimulatory antibodies

    Article :118505

    Nobuhiro Kubo, Minori Baba, Chansu Shin, Yasushi Kasahara, Ryosuke Hosokai, Yudai Murayama, Naoki Oike, Keichiro Mihara, Akihiko Saitoh, Masaru Imamura, Chihaya Imai

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  • ·Exploring the multifunctional potential of designed benzothiazole hydrazones

    Article :118511

    Riccardo Barbari, Vera Bruggink, Robert Klaus Hofstetter, Chiara Tupini, Leonardo Montani, Sofia Fagnani, Filippo Marchetti, Elisa Durini, Ilaria Lampronti, Silvia Vertuani, Anna Baldisserotto, Oliver Werz, Stefano Manfredini

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  • ·Targeting insulin receptor substrate-1 delays disease progression in a murine model of aniridia-associated keratopathy

    Article :118506

    Ava Dashti, Petros Moustardas, Yedizza Rautavaara, Dina Javidjam, Israa Sefawi, Neil Lagali

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  • ·Glutaminase inhibition confers antitumor effects in vitro and in vivo on tyrosine kinase inhibitors-resistant renal cell carcinoma cells by affecting vascular endothelial growth factor signaling

    Article :118492

    Kento Morozumi, Yoshihide Kawasaki, Izumi Sakamoto, Tomonori Sato, Masamitsu Maekawa, Shinya Takasaki, Shinichi Yamashita, Nariyasu Mano, Akihiro Ito

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  • ·Discovery of a novel STAT3 inhibitor: A potential application for pancreatic cancer treatment

    Article :118487

    Xiaoyu Yang, Chia-Nung Hung, Meagan Ybarra, Michelle Villarreal, Pawel Osmulski, Maria E. Gaczynska, Chelliah Selvam, Danmeng Li, Kenneth L. Kho, Glenn A. Halff, David A. Ostrov, Rita Ghosh, Addanki P. Kumar

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  • ·Molecular regulation and subtype-specific effects of naringenin and naringin on nicotinic acetylcholine receptors expressed in Xenopus oocytes

    Article :118494

    Jeongyeon Yun, Myungmi Moon, Jaehui Yang, Hye Duck Yeom, Mee-Hyun Lee, Gihyun Lee, Junho H. Lee

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  • ·Sclareol mitigates steatosis, inflammation, and fibrosis through the regulation of AMPK/SREBP1/NF-κB/TGF-β pathways in metabolic dysfunction-associated steatohepatitis

    Article :118512

    Poonam Yadav, Sumeet Kumar Singh, Ralf Weiskirchen, Umashanker Navik

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  • ·Human sclerostin-inspired short peptides reverse osteoporosis and suppress joint degeneration in osteoarthritis via opposing Wnt pathways

    Article :118501

    Shivani Sharma, Chirag Kulkarni, Neeraj K. Verma, Swati Srivastava, Rosebin Babu, Anupam Ghosh, Nandita Dasgupta, Arvind Gupta, Simran Preet Kaur, Leena Sapra, Swati Rajput, Sreyanko Sadhukhan, Konica Porwal, Devesh P. Verma, Mohd. Sayeed, Asit R. Mridha, Madan M. Godbole, Kumaravelu Jagavelu, Rupesh K. Srivastava, Aravind S. Kshatri, Kinshuk R. Srivastava, Arun K. Trivedi, Shivendu Ranjan, Jimut K. Ghosh, Naibedya Chattopadhyay

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  • ·A consensus HA DNA vaccine targeting clade 2.3.4.4 H5Nx influenza viruses provides broad cross-clade protection in mice and ferrets

    Article :118485

    Chang-Ung Kim, Won-Suk Choi, Pureum Lee, Ju Hwan Jeong, Yong Bok Seo, Young Woo Choi, Myung Ho Sohn, So-Young Choi, Ahn Young Jeong, Min-Suk Song, Doo-Jin Kim

    Résumé Résumé Plan Plan   
  • ·Subclinical tubular kidney injury associated with immune checkpoint inhibitors and cisplatin treatment: Diagnosis through urinary biomarkers

    Article :118430

    Javier Tascón, Alfredo G. Casanova, Laura Vicente-Vicente, Marta Prieto, Ana I. Morales

    Résumé Résumé Plan Plan   
  • ·In vitro screening of synbiotics based on a four-strain probiotic blend and their therapeutic potential for ulcerative colitis

    Article :118521

    Jiahao Liao, Ying Guo, Zhuoya Guo, Xianqian Zhang, Xiaoqiong Li, Jian Kuang, Jianqiang Li, Xiangyu Bian, Weiwei Wang, Jinjun Li

    Résumé Résumé Plan Plan   
  • ·Therapeutic potential of heat-killed Enterococcus faecalis (EC-12) para-probiotic in reversing maternal separation-triggered social deficit in mice

    Article :118513

    Eman A. Mady, Hussein M. El-Husseiny, Yuko Makioka-Itaya, Shodai Ishikawa, Ryo Inoue, Chunmei Li, Yuki Yamamoto, Kentaro Nagaoka

    Résumé Résumé Plan Plan   
  • ·Coumarin attenuates cyclophosphamide-induced premature ovarian failure in mice by suppressing oxidative stress and apoptosis

    Article :118528

    Negar Pouladvand, Mahnaz Azarnia, Rouhollah Fathi, Hadis Zeinali, Samira Vesali, Somayeh Tavana

    Résumé Résumé Plan Plan  
  • ·Neuroavailable peptides from hempseed protein hydrolysates reduce hippocampal inflammation and glial activation in a scopolamine-induced Alzheimer’s disease

    Article :118438

    Maria Torrecillas-Lopez, Carmen M. Claro-Cala, Teresa Gonzalez-de la Rosa, Luna Barrera-Chamorro, M. Carmen Millan-Linares, Elvira Marquez-Paradas, Alvaro Villanueva, Jose L. del Rio-Vazquez, Sergio Montserrat-de la Paz

    Résumé Résumé Plan Plan   
  • ·Lawsone can suppress liver fibrosis by inhibition of YAP signaling and induction of CYGB expression in hepatic stellate cells

    Article :118520

    Atsuko Daikoku, Tsutomu Matsubara, Misako Sato-Matsubara, Miku Ando, Chiho Kadono, Sayuri Takada, Naoshi Odagiri, Hideto Yuasa, Hayato Urushima, Katsutoshi Yoshizato, Norifumi Kawada, Kazuo Ikeda

    Résumé Résumé Plan Plan   
  • ·Targeting KCNN4 channels modulates microglial activation and apoptosis in a PD-relevant inflammatory model

    Article :118526

    Hao-Yuan Hung, I-Hsun Li, Yung-Ni Lin, Ting-Yin Yeh, Ke-Xin Ng, Tin-An Wang, Kun‑Ting Hong, Teng-Hui Wang, Yi-Chieh Wu, Jui-Hu Shih

    Résumé Résumé Plan Plan   
  • ·Taurine suppresses Aβ aggregation and attenuates Alzheimer’s disease pathologies in 5XFAD mice and patient-derived cerebral organoids

    Article :118527

    Hyewon Lee, Muhammad Kamal Hossain, Hwa-Young Lee, Vijay Kumar, Soo Jung Shin, Byeong-Hyeon Kim, Hyun Ha Park, Jeong Gyu Son, Minho Moon, Hyung-Ryong Kim

    Résumé Résumé Plan Plan   
  • ·Therapeutic potential of matrine and osthole against copper-promoted lung cancer cell malignancy

    Article :118504

    Yinlan Xu, Hejun Liu, Haonan Guo, Jinmei Zheng, Ling Tao, Weidong Wu

    Résumé Résumé Plan Plan  
  • ·Influence of amitriptyline therapy on T cell phenotype in chronic pain patients

    Article :118529

    Matthias Hose, Vivien Blietschau, Fabian Schumacher, Anne Ninnemann, Eyad Naser, Julia Falkenstein, Alexander Carpinteiro, Burkhard Kleuser, Jan Buer, Astrid M. Westendorf, Ulrike Bingel, Daniel Müller, Wiebke Hansen

    Résumé Résumé Plan Plan  
  • ·Aurora B inhibition induces polyploidy and mitotic catastrophe in HER2-amplified breast cancer: Telomere shortening as a potential anticancer mechanism of AZD1152-HQPA

    Article :118509

    Somayeh Alsadat Tara, Ali Zekri, Fattah Sotoodehnejadnematalahi, Mohammad Hossein Modarressi

    Résumé Résumé Plan Plan   
  • ·Neonatal sevoflurane exposure disrupted fatty acids metabolism, leading to hypomyelination and neurological impairments

    Article :118495

    Sufang Jiang, Tianyu Cao, Jiaqi Li, Lichao Di, Xueji Wang, Zhongcong Xie, Lining Huang

    Résumé Résumé Plan Plan   
  • ·Molecular impact of NOTCH signaling dysregulation on ovarian cancer progression, chemoresistance, and taxane response

    Article :118532

    Kamila Koucka, Alzbeta Spalenkova, Karolina Seborova, Tereza Tesarova, Marie Ehrlichova, Ivona Krus, Petr Holy, Lukas Rob, Martin Hruda, Jiri Bouda, Alena Bartakova, Vendula Smoligova, Iwao Ojima, Lei Chen, Hersch Bendale, Marcela Mrhalova, Katerina Kopeckova, Pavel Soucek, Radka Vaclavikova

    Résumé Résumé Plan Plan   
  • ·Oral nanoformulation of a host-directed antiviral niclosamide effectively treats severe fever with thrombocytopenia syndrome

    Article :118533

    Satabdi Acharya, Hae-mi Kim, Chongkai Zhai, Tsenddari Ganbold, Hyeon Jin Kim, Seong Tshool Hong

    Résumé Résumé Plan Plan   
  • ·Linalyl acetate prevents D-galactose and nicotine-induced increases in intracellular Ca²⁺ by inhibiting phospholipase D hyperactivation in MOVAS and L6 cells

    Article :118538

    Yoo Jin Kim, Jiwoo Shin, Geun Hee Seol

    Résumé Résumé Plan Plan  
  • ·Protective effects of the bacterial pigment violacein against gastric ulceration: Inhibition of acid-related enzymes, activation of protective pathways, and reduction of inflammation and oxidative stress

    Article :118544

    Faiza I.A. Abdella, Dalal Alardan, Nawal S. Alshammari, Ahlam Abdulrahman Alrashdi, Ola Abdelhedi, Khaled Hamden

    Résumé Résumé Plan Plan  
  • ·Insights into histone deacetylase inhibitors-induced cell death in cancer cell lines

    Article :118541

    María Fuentes-Baile, Pilar García-Morales, Elizabeth Pérez-Valenciano, Trinidad Mata-Balaguer, María P. Menéndez-Gutiérrez, Camino de Juan Romero, Álvaro Rodríguez-Lescure, Elena Martín-Orozco, Ricardo Mallavia, Víctor M. Barberá, Miguel Saceda

    Résumé Résumé Plan Plan   
  • ·Smart co-delivery of Erlotinib and Camptothecin using silica-coated gold nanorods functionalized with recombinant anti-bone morphogenetic protein receptor type I (BMPR-AI)

    Article :118540

    Fatemeh Sabzalizadeh, Hamed Mirshekari, Nediljko Budisa, Khosro Khajeh, Hamid-Reza Karbalaei-Heidari

    Résumé Résumé Plan Plan   
  • ·Novel antitubercular agents based on 2,4-disubstituted 5-(aryl-2-ylmethyl)-5H-pyrrolo[3,2-d]pyrimidines

    Article :118537

    Vladimir Finger, Martin Vrbicky, Lubica Muckova, Lukas Prchal, Martin Novak, Jan Marek, Ondrej Soukup, Michaela Hympanova, Ales Sorf, Marketa Benkova, Jan Bartacek, Pavel Drabina, Martin Kufa, Ondrej Kovar, Lenka Fikejzlová, Martin Hruby, Oksana Ozhelevska, Johannes Jagob, Jana Zdarova-Karasova, Jitka Odvarkova, Iveta Kaderavková, Tomas Rozsypal, Katarzyna Ewa Greber, Krzesimir Ciura, Jiri Janousek, Martin Kratky, Ivone C. Igreja Sa, Pavel Bostik, Radek Sleha, Jaroslav Roh, Jan Korabecny

    Résumé Résumé Plan Plan   
  • ·Givinostat inhibits in vitro differentiation of cardiac fibroadipogenic precursors from a mouse model of arrhythmogenic cardiomyopathy

    Article :118549

    Sara Vencato, Chiara Romanato, Monica Forino, Gianluca Fossati, Angelo Velle, Nicola Facchinello, Paola Braghetta, Simonetta Andrea Licandro, Chiara Romualdi, Martina Calore, Libero Vitiello, Christian Steinkuhler, Alessandra Rampazzo

    Résumé Résumé Plan Plan   
  • ·Light-enhanced cytotoxicity and intracellular trafficking of the PD-L1-targeting photoimmunoconjugate EITC-atezolizumab

    Article :118550

    Manuela Maria Alampi, Magdaléna Kozlíková, Matteo Mariangeli, Simone Civita, Pietro Delcanale, Andrea Mussini, Alberto Diaspro, Paolo Bianchini, Anette Weyergang, Ellen Skarpen, Kristian Berg, Cristiano Viappiani, Stefania Abbruzzetti, Pål Kristian Selbo

    Résumé Résumé Plan Plan   
  • ·Unraveling the cellular mechanisms of thiopurine-induced pancreatitis in pediatric inflammatory bowel disease: Insights from induced pluripotent stem cell models

    Article :118539

    Paola Rispoli, Elena Genova, Fengming Yue, Kohei Johkura, Martina Franzin, Ute Hofmann, Matthias Schwab, Rosalba Monica Ferraro, Elena Laura Mazzoldi, Silvia Clara Giliani, Giovanna Piovani, Matteo Bramuzzo, Stefano Martelossi, Erasmo Miele, Massimo Martinelli, Federico Marchetti, Marco Pelin, Giuliana Decorti, Marianna Lucafò, Gabriele Stocco

    Résumé Résumé Plan Plan   
  • ·Oral nutraceutical intervention to improve endothelial function: Evidence from in vitro and pilot clinical studies

    Article :118552

    Vincenza Valerio, Veronika A. Myasoedova, Ilaria Massaiu, Alessio Ravani, Beatrice Frigerio, Valentina Rusconi, Francesca Bertolini, Giulio Pompilio, Paolo Poggio

    Résumé Résumé Plan Plan   
  • ·Sex differences in response to NLRP3 inflammasome blockage in a mouse migraine model: A genetic and pharmacological study

    Article :118411

    Michela Argentieri, Caterina Boncompagni, Chiara Sturaro, Pietro Pola, Clotilde d’Ugo, Alessia Frezza, Simona Stragapede, Salvatore Pacifico, Valentina Albanese, Delia Preti, Tommaso Iannitti, Paolo Pinton, Carlotta Giorgi, Chiara Ruzza, Sonia Missiroli

    Résumé Résumé Plan Plan   

• Corrigendum

  • ·Corrigendum to “Ginkgolide B effectively mitigates neuropathic pain by suppressing the activation of the NLRP3 inflammasome through the induction of mitophagy in rats” [Biomed. Pharmacother. 177 (2024) 117006]

    Article :118478

    Jing-Hao Liang, Heng Yu, Chuan-Peng Xia, Yue-Hui Zheng, Zhe Zhang, Yu Chen, Mazhar Ali Raza, Long Wu, Hede Yan

     
  • ·Corrigendum to “The benefits of hesperidin in central nervous system disorders, based on the neuroprotective effect” [Biomed. Pharmacother. 159 (2023) 114222]

    Article :118479

    Xinyu Li, Wei Huang, Rongrong Tan, Caijuan Xu, Xi Chen, Sixin Li, Ying Liu, Huiwen Qiu, Hui Cao, Quan Cheng

     
  • ·Corrigendum to “Chemotherapy against Toxoplasma gondii: A bibliometric analysis of in vitro and mouse model studies (2015–2024)” [Biomed. Pharmacother. 186 (2025) 117956]

    Article :118483

    Juliana Quero Reimão, Fernanda Ferreira Evangelista, Stephanie Ortega Alves, Tayline Torres, Josinara do Espirito Santo Lobo, Kayo Thiago Ribeiro Perroni, Rafael Meyer Mariante

    
  • ·Corrigendum to “PDE5 inhibition mitigates heart failure in hyperlipidemia” [Biomed. Pharmacother. 175 (2024) 116710]

    Article :118534

    Wuqing Huang, Xi Yang, Naiqi Zhang, Keyuan Chen, Jun Xiao, Zhihuang Qiu, Sujun You, Ziting Gao, Jianguang Ji, Liangwan Chen

     
  • ·Corrigendum to “Niosomal hesperidin ameliorates depression-induced behavioral, histological, and molecular alterations in the rat hippocampus” [Biomed. Pharmacother. 191 (2025) 118473]

    Article :118535

    Mahsa Otarkhani, Homeira Hatami, Yousef Panahi, Abdallah Al Jammal, Reihaneh Sadeghian, Sama Yavari

    
  • ·Corrigendum to “Liraglutide, a glucagon-like peptide-1 receptor agonist, suppresses osteoclastogenesis through the inhibition of NF-κB and MAPK pathways via GLP-1R” [Biomed. Pharmacother. 130 (2020) 110523]

    Article :118545

    Ziyi Li, Shilun Li, Na Wang, Peng Xue, Yukun Li

     
  • ·Corrigendum to “Ephedra herb reduces adriamycin-induced testicular toxicity by upregulating the gonadotropin-releasing hormone signalling pathway” [Biomed. Pharmacother., vol. 150 (2022): 113061]

    Article :118554

    Yang Fu, PeiPei Yuan, Yajuan Zheng, Liyuan Gao, Yaxin Wei, Yi Chen, Panying Li, Yuan Ruan, Xiaoke Zheng, Weisheng Feng

     

• Retractions

  • ·Retraction notice to “CircPIP5K1A activates KRT80 and PI3K/AKT pathway to promote gastric cancer development through sponging miR-671-5p” [Biomed. Pharmacother. 126 (2020) 109941]

    Article :118382

    Hu Song, Yixin Xu, Teng Xu, Ruizhi Fan, Tao Jiang, Meng Cao, Linseng Shi, Jun Song

    
  • ·Retraction notice to “Long non-coding RNA PVT1 promotes cell proliferation and invasion through regulating miR-133a in ovarian cancer” [Biomed. Pharmacother. 106 (2018) 61–67]

    Article :118383

    Qi Yang, Yang Yu, Ziqian Sun, Yuan Pan

    
  • ·Retraction notice to “Histone demethylase KDM5A inhibits glioma cells migration and invasion by down regulating ZEB1” [Biomed. Pharmacother. 99 (2018) 72–80]

    Article :118546

    Bin Dai, Hui Huang, Feng Guan, Guangtong Zhu, Zhiyong Xiao, Beibei Mao, Haiyang Su, Zhiqiang Hu

    
  • ·Retraction notice to “LncRNA LINC00689 promotes the growth, metastasis and glycolysis of glioma cells by targeting miR-338–3p/PKM2 axis” [Biomed. Pharmacother. 117 (2019) 109069]

    Article :118547

    Xin Liu, Qiaojuan Zhu, Yang Guo, Zunqiang Xiao, Linjun Hu, Qiuran Xu

    
  • ·Expression of concern “Ex vivo, in vitro, and in silico approaches to unveil the mechanisms underlying vasorelaxation effect of Mentha Longifolia (L.) in porcine coronary artery” [Biomed. Pharmacother. 153 (2022) 113298]

    Article :118484