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• • ·Editorial Board

    Article :118906

    

• Review Articles

  • ·Epigenetic crosstalk in bone and cartilage disorders: Emerging role of extracellular vesicles

    Article :118706

    Mahsa Ghorbaninejad, Sedigheh Kamrani, Zeynab Ghorbaninejad, Samaneh Hosseini

    Résumé Résumé Plan Plan  
  • ·Fuelling resistance: Lipid metabolic rewiring in cancer response to chemotherapy and radiotherapy

    Article :118715

    Viktoria Piatrikova, Eva Kocianova, Lucia Skvarkova, Tereza Golias

    Résumé Résumé Plan Plan  
  • ·DNA repair pathways in ovarian cancer: Implications for therapy and resistance

    Article :118719

    Isabel Miras, Inmaculada Vázquez-Gutierrez, Purificación Estévez-García, Sandra Muñoz-Galván

    Résumé Résumé Plan Plan  
  • ·Breaking the hypoxia barrier: Advances and challenges of hyperbaric oxygen therapy in cancer treatment

    Article :118703

    Youda Meng, Liang Zhou, Yong Xia, Chengsen Jia, Liyi Huang

    Résumé Résumé Plan Plan  
  • ·Emerging roles of NLRP3 inflammasome-mediated pathways in pulmonary fibrosis: Current knowledge and therapeutic strategies

    Article :118717

    Can Xiao, Yanfei Xie, Xiang Liu, Haibo Lei

    Résumé Résumé Plan Plan  
  • ·Current perspectives on the human skin microbiome: Functional insights and strategies for therapeutic modulation

    Article :118655

    Hitakshika Suri, Harshika Suri, Nachiket Nagda, Toshika Misra, Suneetha Vuppu

    Résumé Résumé Plan Plan  
  • ·Circular RNAs as central regulators of metabolic reprogramming and immune responses in the breast cancer microenvironment: A comprehensive review

    Article :118682

    Negar Sadat Sherafat, Amirhossein Mardi, Faezeh Absalan, Amirreza Mehmandar-Oskuie

    Résumé Résumé Plan Plan  
  • ·A review of Farnesiferol C: From molecular insights to anticancer potential and emerging therapeutic applications

    Article :118725

    Louna El Bitar, Fares Sarraf, Perla Nafeh, Aziz Habib, Issam Mahfoud, Abraham Yazbeck, Maria Younes, Brigitte Wex, Sandra Rizk

    Résumé Résumé Plan Plan   
  • ·Relationship between hepatic lipid accumulation and type 2 diabetes mellitus

    Article :118723

    Zhe Wang, Wang Zan, Zhe Fan, Shuang Wang

    Résumé Résumé Plan Plan  
  • ·Comparative safety and side effects of semaglutide and tirzepatide: Implications for clinical decision-making in obesity management

    Article :118731

    Sally A. Fahim, Yasmin M. Attia, Albeir Messiha, Ashrakat Y. Nabawy, Fady Refaat, Walaa H. El-Maadawy

    Résumé Résumé Plan Plan  
  • ·Ruthenium-based drugs as cancer stem cell inhibitors

    Article :118730

    Ingrid R.S.B. Dias, Daniel P. Bezerra

    Résumé Résumé Plan Plan  
  • ·Nano-enhanced photodynamic therapy and machine learning: Advancements, challenges, and future directions

    Article :118710

    Alexander Chota, Heidi Abrahamse, Blassan P. George

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  • ·Inhibition of transient receptor potential vanilloid 4: A promising novel strategy for myocardial ischemia/reperfusion injury treatment

    Article :118765

    Qian Dong, Zhanpeng Wang, Qiongfeng Wu, Yimei Du

    Résumé Résumé Plan Plan  
  • ·Effect of mitochondrial dysfunction on neuropathic pain

    Article :118760

    Yunqi Li, Ping Wu, Qingping Wen

    Résumé Résumé Plan Plan  
  • ·Exploring the impact of metformin on the central nervous system and neurotransmission: A systematic review

    Article :118743

    Aleksandra Maciejczyk, Kamilla Blecharz-Klin

    Résumé Résumé Plan Plan   
  • ·Exploring and bypassing resistance to targeted therapies in colorectal cancer

    Article :118741

    Solène Favier, Wei Xiong, Mounira Chalabi-Dchar, Kamel Chettab, Oliver Piercey, Ting Wu, Tanguy Fenouil, Marie-Alexandra Albaret, Lars Petter Jordheim, Jean-Jacques Diaz, Frédéric Hollande, Charles Dumontet, Hichem C. Mertani

    Résumé Résumé Plan Plan  
  • ·Targeting PRMT5 in cancer: Mechanistic insights and clinical progress

    Article :118754

    Joohyun Lee, Jiye Kim, Inah Hwang

    Résumé Résumé Plan Plan  
  • ·Role of JNK3 signaling in acute ischemic stroke cerebroprotection: A systematic review

    Article :118749

    Federica Ferrari, Federico Mazzacane, Beatrice del Bello, Anna Cavallini, Domenico Raimondo, Tiziana Borsello

    Résumé Résumé Plan Plan   
  • ·Galectin-3 as a therapeutic target in pulmonary hypertension: Molecular mechanisms, drug development directions, and emerging clinical applications

    Article :118756

    Antonín Sedlář, Pavla Bojarová, František Kolář, Vladimír Křen, Lucie Bačáková

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  • ·Exosomal microRNA in diabetic myocardial disorder: Mechanisms, diagnosis, and treatment

    Article :118761

    Yunfeng Yu, Xinyu Yang, Yuman Yin, Lina Qin, Qin Xiang, Rong Yu

    Résumé Résumé Plan Plan  
  • ·The CXCL13–CXCR5 axis and follicular cytotoxic T cells: Linking T–B crosstalk in autoimmune diseases

    Article :118784

    Shun-yu Yao, Yong Peng, Xiuli Zhang, Huan Yang, Sugimoto Kazuo, Jia Liu, Miao-qiao Du, Lan-xin Lin, Quan Chen, Hong Jin

    Résumé Résumé Plan Plan  
  • ·Binding domains of α-synuclein receptors with monomeric/oligomeric α-synuclein: Implications for Parkinson’s disease

    Article :118802

    Rosalie Elvira, Jia Sheng Guan, Yuguang Mu, Eng-King Tan, Zhi Dong Zhou

    Résumé Résumé Plan Plan  
  • ·Cytosolic DNA sensing pathway in senescence and aging: Underlying mechanisms and targeted interventions

    Article :118790

    Elaheh Alipour-Khezri, Amin Moqadami, Sepideh Zununi Vahed, Abolfazl Barzegari

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  • ·Cyclic nucleotide phosphodiesterase 1 and cognitive impairment: Mechanistic insights and therapeutic implications

    Article :118796

    Hailiang Li, Olivia Brzostek, Jason Sherman, Mathew Ayoub, Ling Chen, Zhutao Sheng, Fu Xu, Baomin Dou, Weizheng Wang, Xiongwei Zhu, Chen Yan, Ying Xu

    Résumé Résumé Plan Plan  
  • ·Fat for thought: Lipid regulation of neural stem cell fate

    Article :118785

    Joan Cabot, Ain Justin Santillan, Paula Férnandez-García, Victoria Llado, Manuel Torres, Pablo V. Escribá, Enrico Castroflorio

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  • ·Urine-derived stem cells: The biomedical research of endothelial and cardiovascular tissue

    Article :118792

    Dominika Domagała, Piotr Paweł Chmielewski, Aleksandra Partyńska, Julia Niebora, Krzysztof Data, Magdalena Kulus, Marta Podralska, Agnieszka Matuszewska, Bogusław Czerny, Michał Soczawa, Adam Kamiński, Kornelia Krajnik, Paul Mozdziak, Hanna Piotrowska-Kempisty, Maciej Zabel, Piotr Dzięgiel, Bartosz Kempisty

    Résumé Résumé Plan Plan  
  • ·Therapeutic promise of α-hederin in Alzheimer’s disease: Insights into inflammation, oxidative stress, and apoptosis modulation

    Article :118803

    Ananda Kumar Chettupalli, Neha Gupta, Sarad Pawar Naik Bukke, Mukul Pratap Singh, Chandan Mandal

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  • ·Regression of oxidative stress by targeting Nrf2/HO-1 signaling: The potential therapeutic drugs for cerebral ischemia-reperfusion injury

    Article :118809

    Hao-Ming Zhou, Yun Chai, Xi Mao, Jia-Xing Rao, Shuo Zhang, Gui-Sheng Zhou, Kim Fey Leu, Yu-Ping Tang, Jin-Ao Duan

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  • ·Bacteriophage antimicrobial therapy: From mechanism exploration to biomedical applications

    Article :118502

    Ling Zhao, Xiaohua Li, Hailin Cong, Bing Yu

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  • ·Gut-eye axis in ophthalmic diseases: Focus on ocular neurodegeneration

    Article :118800

    Lujia Zhou, Yan Ma, Xiumiao Li, Guofan Cao

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  • ·Tumor-derived extracellular vesicles: Bridging communication and next-generation theranostics

    Article :118815

    Jace Chen, Apple Verdiell, Carlos Formoso, Myles Luciano, Celine Chen, Abhimanyu Thakur

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  • ·Pharmacological mechanisms and clinical applications between SGLT1 and SGLT2 inhibitors in type 2 diabetes and diabetic kidney disease: An analytic review

    Article :118837

    Ziyang Zhang, Yupeng Li, Harvest F. Gu, Nan Li

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  • ·Nanobody CAR-T cells in cancer: From molecular design to clinical translation

    Article :118819

    Alaa Rifaah Eisa, Fatemeh Tavassoli Razavi, Akram Hoseinzadeh, Dariush Haghmorad, Rasoul Baharlou

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  • ·Endoplasmic reticulum, mitochondria, and their crosstalk in retinal ganglion cell degeneration

    Article :118835

    Baohua Li, Yipeng Shi, Mengyu Liu, Wengxuan Cao, Fuyuan Zhang, Zefeng Kang

    Résumé Résumé Plan Plan  
  • ·Exosome therapeutics: A paradigm shift in skin repair through multidimensional immunomodulation and biomaterial-driven delivery

    Article :118830

    Tinghan Deng, Yiyi Zhang, Yabo Yao, Pingfang Ye, Dan Zhang, Fengrui Cheng, Jingping Wu, Hongbin Cheng, Jun Lu

    Résumé Résumé Plan Plan  
  • ·Effects of GnRH agonists and antagonists on cardiovascular and metabolic systems in adults: Mechanistic pathways and risk management

    Article :118860

    Atoosa Etezadi, Seyed Mehdi Marashi, Leila Nazari, Mozhgan Sina, Fatemeh Samadi Nasab, Shahrzad Amirlatifi, Somaye Zamanifard, Ziba Zahiri, Farnaz Khodaparast

    Résumé Résumé Plan Plan  
  • ·Innovative CAR-T approaches targeting Claudin 18.2 to counteract drug resistance in gastric cancer

    Article :118863

    Giovanni Calice, Carlo Calabrese, Tiziana Notarangelo

    Résumé Résumé Plan Plan  
  • ·Harnessing cuproptosis for pancreatic cancer therapy: From molecular insights to clinical prospects

    Article :118852

    Ali Darzi, Siavash Boroumandi, Pouriya Khajegi, Mohammad Reza Dehdashti, Pedram Abdali, Mohammad Moein Amerinia, Fatemeh Kheirkhah, Mohammad Mahdi Ajalli, Mahla Shokouhfar

    Résumé Résumé Plan Plan  
  • ·The role of gut dysbiosis and mitochondrial dysfunction in type 2 diabetes: Insights on pathogenesis, intervention and future perspective

    Article :118846

    Xuefei Yu, Mingxiao Li, Houkai Li

    Résumé Résumé Plan Plan  
  • ·Metabolic modulation as a therapeutic strategy for post-acute vaccination syndrome (PACVS): A review of pathomechanisms and existing therapeutic components

    Article :118864

    Matthew Halma, Joseph Varon

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  • ·Immune checkpoint inhibition in renal cell carcinoma: Mechanisms of resistance and emerging therapeutic strategies

    Article :118875

    Ali Darzi, Mahla Shokouhfar, Narges Farajee, Arezoo Ghafari, Fatemeh Deldar, Pooya Eini, Ahmad Ghorbani Vanan, Nastaran Bahrami

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  • ·Dexmedetomidine in ischemic and hemorrhagic brain injury: Neuroprotection from mechanisms to therapy

    Article :118872

    Yixiao Zhu, Andi Chen, Chenglin Gai, Li Lin, Chengqian Teng, Jianjie Wei, Yanping Yang, Xiaoxia Wei, Xiaohui Chen

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  • ·Aging hearts, fibrotic fears: The sirtuin connection

    Article :118882

    Arkadiusz Grzeczka, Szymon Graczyk, Xutong Gong, Jan Gröschel, Sebastian Spethmann, Pawel Kordowitzki

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  • ·Exosomal proteins as drivers of metastasis to distant organs

    Article :118886

    Israel Martínez-Espinosa, José A. Serrato, Jesús Germán-Valenzuela, Blanca Ortiz-Quintero

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  • ·Drug repurposing in gynaecological cancers: Proven drugs for new challenges

    Article :118885

    Amani Alghalayini, Farhana A. Sarker, Kristie-Ann Dickson, Nikola A. Bowden, Deborah J. Marsh

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  • ·Microbiota-brain interaction: The role of gut-derived proteins in addressing various neurological disorders including Parkinson’s (PD) and Alzheimer’s diseases (AD)

    Article :118861

    Tahreen Taj, Monika Kaushik, Anas Islam, Joy Das, Bimlesh Kumar, Md Sadique Hussain, Mohhammad Ramzan, Sumel Ashique, Mohd Tariq, Sathvik Belagodu Sridhar, Sabina Yasmin, Uttam Prasad Panigrahy, Tabarak Malik, Mohammad Yousuf Ansari

    Résumé Résumé Plan Plan  
  • ·Exosomes in assisted reproductive technologies: Discovery of new mechanisms and therapeutic possibilities

    Article :118889

    Vida Ebrahimi, Samaneh Abdolmohammadi-Vahid, Mohammad Sadegh Soltani-Zangbar, Hamid Ahmadi, Leili Aghebati-Maleki

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  • ·Nanotechnology-based approaches for head and neck cancer treatment

    Article :118871

    Almudena del Campo-Balguerías, Corina Lorz, Alberto Ocaña, Iván Bravo, Carlos Alonso-Moreno

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  • ·Chiglitazar, a PPAR pan-agonist: Impacts on type 2 diabetes mellitus and multi-system metabolic regulation – A review

    Article :118850

    Ee Chang, Yiran Zhu, Wei Wei, Jiaxuan Huai, Tiansu Lv, Yan Lou, Xiqiao Zhou

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• Original Articles

  • ·Anti-inflammatory therapies from bedside to bench: Frameworks to support preclinical development

    Article :118667

    Cristina Cigana, Alice Rossi, Davide Gugliandolo, Ida De Fino, Alessandra Bragonzi

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  • ·AS-IV inhibits the progression of ovarian cancer by targeting the circ_0124787/miR-6875–3p/IL-1β axis

    Article :118681

    Nan Fu, Siyue Zhang, Ziyi Xiao, Lihua Zhang, Jindong Dai, Xiaojian Liu, Dongwei Zhu, Jinhua Wang

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  • ·Suppression of choroidal neovascularization by nonviral gene transfer of pigment epithelium-derived factor

    Article :118711

    Mingliang Zhang, Jikui Shen, Kathryn M. Luly, Yeongseo Lim, Sydney R. Shannon, Manav Jain, Stephany Y. Tzeng, Sean Hackett, Yogita Kanan, Jordan J. Green, Peter A. Campochiaro

    Résumé Résumé Plan Plan  
  • ·CliCAR: A non-genetic CAR engineering strategy to empower NK cells for targeted cancer immunotherapy

    Article :118691

    Su Yeon Lim, Yeongbeom Kim, Seungmin Han, Hyun-Ouk Kim, Suk-Jin Ha, Jeong-Ann Park, Jina Yun, Sehyun Chae, Young-Wook Won, Kwang Suk Lim

    Résumé Résumé Plan Plan   
  • ·Physiologically-based pharmacokinetic modeling of enavogliflozin ophthalmic solution for starting dose selection in diabetic retinopathy treatment

    Article :118722

    Dong Wook Kang, Seok-jin Cho, Go-Wun Choi, Ju Hee Kim, Hea-Young Cho

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  • ·Cilostazol or canagliflozin mitigates Cyclosporine A-induced nephrotoxicity by modulating the STAMP2-mTOR-AMPK signaling pathway and autophagy in a rat model

    Article :118718

    Mohamed Raafat Abdul Samad, Hala M.F. Mohammad, Islam Omar Abdel Fattah, Samar Imbaby

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  • ·Deciphering the structural impact of norepinephrine analog radiopharmaceuticals on organic cation transporter affinity

    Article :118724

    Saskia Mühlig, Xinyu Chen, Anna Tutov, Naoko Nose, Constantin Lapa, Rudolf A. Werner, Michael Decker, Takahiro Higuchi

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  • ·Psilocybin as a fast-acting and long-lasting antidepressant for adolescence: Proposing NeuroD1 as a biomarker of its long-term plasticity

    Article :118720

    Rubén García-Cabrerizo, Itziar Beruete-Fresnillo, Pedro Bergas-Cladera, M. Julia García-Fuster

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  • ·Novel 1,4-benzothiazepin-2-one modulators of NCX3 as a promising strategy for neuroprotection in cerebral ischemia

    Article :118709

    Antonia Scognamiglio, Angela Corvino, Agata Zięba, Agnieszka A. Kaczor, Agnese Secondo, Anna Pannaccione, Tuomo Laitinen, Paolo Luciano, Rocco Vitalone, Ornella Cuomo, Ester Licastro, Viviana Viscardi, Lucio Annunziato, Ferdinando Fiorino, Francesco Frecentese, Elisa Magli, Elisa Perissutti, Vincenzo Santagada, Giuseppe Pignataro, Giuseppe Caliendo, Beatrice Severino

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  • ·Rapamycin and parenteral administration attenuate the harmful effects of glucocorticoids on the intestinal barrier function

    Article :118721

    Diego Ceacero-Heras, Guillermo Ruiz-Henares, Juan José Enguix-Huete, Mireia Tena-Garitaonaindia, Ángela Jiménez-Ortas, Alba Seguí-Pérez, Olga Martínez-Augustin, Fermín Sánchez de Medina

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  • ·A clinically translatable 2.5D lung adenocarcinoma organoid platform derived from malignant pleural effusions for precision drug screening and tumor-immune-stromal modeling

    Article :118712

    Shaowei Lan, Lixia Ma, Chenchen Tang, Xinyue Wang, Ying Liu, Rixin Li, Yan Liu, Rui Zhong, Hui Li, Ying Cheng

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  • ·Exploring the anti-hyperalgesic effects of ethyl gallate in fibromyalgia-like behaviors in mice

    Article :118685

    Elaine Cristina Dalazen Gonçalves, Tainara Ribeiro Gonçalves, Nádia Rezende Barbosa Raposo, Martina Simonelli, Raffaele Capasso, Rafael Cypriano Dutra

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  • ·Discovery of novel hybrid pyrrolidin-2-one derivatives exhibiting potent antiseizure and antinociceptive effects in preclinical models

    Article :118728

    Marcin Jakubiec, Michał Abram, Mirosław Zagaja, Katarzyna Socała, Vanja Panic, Gniewomir Latacz, Szczepan Mogilski, Małgorzata Szafarz, Aleksandra Szewczyk, Jerry Saunders, Peter J. West, Katarzyna Przejczowska-Pomierny, Klaudia Stasiak, Jakub Słota, Jakub Jasiński, Anna Czopek, Elżbieta Wyska, Piotr Wlaź, Cameron S. Metcalf, Karen Wilcox, Marta Andres-Mach, Krzysztof Kamiński

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  • ·Apixaban kinetics could be influenced by sex, cytochrome P450 enzymes and SLC6A2 transporter

    Article :118732

    Eva González-Iglesias, Dolores Ochoa, Houwaida Abbes, Gonzalo Villapalos-García, Manuel Román, Sergio Luquero, Samuel Martín-Vilchez, Jesús Novalbos, y Francisco Abad-Santos

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  • ·Monotropein improves late-onset hypogonadism in TM3 Leydig cells and aged rats

    Article :118734

    Hee-Yeon Kwon, Hyesung Lee, Ji-Soo Choi, Seong Hun Lim, Taehyun Kim, Kyeongseok Bae, Eun-Min Kim, Jae-Yeon Lee, Eun-Young Park, Se-Young Choung, Do Sik Min

    Résumé Résumé Plan Plan   
  • ·Inhibition of ATP citrate lyase does not affect muscle mitochondrial activity in apoE^-/- mice

    Article :118726

    Chiara Macchi, Isabella Fichtner, Tasnim Mohamed, Elsa Franchi, Alessandra Stefania Rizzuto, Chiara Pavanello, Jurgen Gindlhuber, Simone Nerini, Cesare R. Sirtori, Elena Osto, Stefano Carugo, Marco Busnelli, Giulia Chiesa, Valerio Magnaghi, Alberto Corsini, Massimiliano Ruscica

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  • ·Finerenone prevents renal damage by enhancing SDF-1α/CXCR4-mediated stem cell mobilization in experimental type 1 diabetic nephropathy

    Article :118727

    Paloma Palma-Guzmán, Elvira Bragado-García, Esther Durán-Mateos, Marta Sanz-Gómez, Christopher Overall, Isabel Aranguez, Elisa Mercado-García, Gema Ruiz-Hurtado, Reinhold Kreutz, Adrián Plaza, José Joaquín Merino, María S. Fernández-Alfonso

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  • ·Carboxylated graphene quantum dots as a nano-delivery system for insoluble curcumin in antimicrobial photodynamic therapy

    Article :118696

    Kateřina Bartoň Tománková, Hanna Dilenko, Renata Večeřová, Adéla Hanáková, Lucie Válková, Markéta Kolaříková, Lukáš Malina, Robert Bajgar, Sergii Kalytchuk, Klára Čepe, S.M. Hossein Hejazi, Milan Kolář, Hana Kolářová

    Résumé Résumé Plan Plan  
  • ·Drug target proteome profiling identifies HES1-driven mitotic catastrophe in ovarian serous carcinoma

    Article :118716

    Jie Bao, Sanna Pikkusaari, Jun Dai, Samuel Leppiniemi, Wenjun Huang, Weiming Yang, Anu Anil, Mirva Pääkkönen, Chuqi Lei, Eva Daniela Mendoza-Ortiz, Ezgi Karagöz, Johanna Eriksson, Min Li, Johanna Hynninen, Otto Kauko, Anniina Färkkilä, Anna Vähärautio, Sampsa Hautaniemi, Liisa Kauppi, Jing Tang

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  • ·New aminoadamantane derivatives as inhibitors of F13 envelope protein from mpox virus

    Article :118684

    Thaís de Fátima Silva Moraes, Erik Vinicius de Sousa Reis, Gabriela Aparecida Azevedo, Mateus Sá Magalhães Serafim, Felipe Alves Clarindo, Victor de Melo Rocha, Marília Bueno da Silva Menegatto, Erna Geessien Kroon, Edel Figueiredo Barbosa-Stancioli, Karine Lima Lourenço, Flávio Guimarães da Fonseca, Ângelo de Fátima, Jordana Grazziela Alves Coelho-dos-Reis

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  • ·Repurposed membrane-targeting RS17053 eradicates MRSA persisters and enhances aminoglycoside killing

    Article :118763

    Seongeun Baek, Guijin Zou, Nakyung Lee, Jisoo Kang, Jae-Seok Kim, Wonhyo Seo, Huajian Gao, Wooseong Kim

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  • ·Plasma metabolic profiling identifies elevated hippurate as a potential biomarker of methotrexate non-response in juvenile idiopathic arthritis

    Article :118755

    Amar Kumar, Mara L. Becker, Ryan S. Funk

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  • ·Fish-derived lipids directly stimulate NK cell activity and IFN-γ synthesis: A novel dietary intervention strategy to enhance antiviral immunity in humans

    Article :118778

    Magdalena Namiecińska, Mirella Stańdo-Retecka, Pawel Piatek, Radoslaw Bonikowski, Karol Parchem, Sylwia Michlewska, Filip Kozak, Natalia Lewkowicz, Przemyslaw Lewkowicz

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  • ·Metabolic stress-response in female rats: β-oxidation-induced vulnerability vs adaptive resilience

    Article :118747

    Paola Brivio, Silvia Pedretti, Maria Teresa Gallo, Arianna Palumbo, Marta Boccazzi, Piotr Gruca, Magdalena Lason, Ewa Litwa, Dominika Biala, Fabio Fumagalli, Mariusz Papp, Nico Mitro, Francesca Calabrese

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  • ·Myrcene as a potential natural treatment in mild traumatic brain injury: Neurosensory changes

    Article :118733

    Roozbe Bonsale, Milena Melake Teweldemedhin, Rebecca Limongelli, Michela Perrone, Federica Ricciardi, Andrea Maria Morace, Viviana Iodice, Ida Marabese, Fabiana Piscitelli, Carmela Belardo, Francesca Guida, Vincenzo Di Marzo, Sabatino Maione, Livio Luongo

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  • ·Evaluation of the pharmacological cathepsin S inhibitor LY3000328 on autoimmune diabetes in mice

    Article :118744

    Caroline Frørup, Cecilie A.B. Svane, Mathias Høj Jensen, Laurits J. Holm, Kristina Pedersen, Mia Ø. Mønsted, Karsten Buschard, Joachim Størling, Flemming Pociot, Martin Haupt-Jorgensen, Tina Fløyel

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  • ·Evaluation of antidepressant and sleep-promoting effects of cordycepin in a menopause-like stress model

    Article :118766

    Min Sook Ye, Su-Chan Lee, Si-Kwan Kim, Insop Shim

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  • ·A phenotype-driven data and drug repurposing strategy used to identify potential treatments targeting chondrocyte hypertrophy in osteoarthritis

    Article :118773

    Judith Veldman, Mauricio N. Ferrao Blanco, Nicole Kops, Wendy J.L.M. Koevoet, Eric M.J. Bindels, Gregory van Beek, Remco M. Hoogenboezem, Kavitha Sivasubramaniyan, Jeroen van Rooij, Andrea Lolli, Eric Farrell, Gerjo J.V.M. van Osch

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  • ·Ibogalogs improve spatial and recognition memory in rodents through a mechanism involving 5-HT_2A receptor activation-enhanced NMDA receptor activity in hippocampal pyramidal CA1 neurons

    Article :118742

    Abdeslam Chagraoui, Luis A. Haro Santillan, Renata Bocian, Sarah J. Cohen, Yuliana E. Sarmiento Ruíz, Marli Knox, Paulina Kazmierska-Grebowska, Weronika Zimoń, Robert W. Stackman, Jorge Flores-Hernandez, Hugo R. Arias

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  • ·Novel insights into the effects of JMV2894, a growth hormone secretagogue, in Duchenne muscular dystrophy: A preclinical study in the D2-mdx mouse model

    Article :118767

    Paola Mantuano, Brigida Boccanegra, Manuel Marinelli, Enrica Cristiano, Roberta Lenti, Lisamaura Tulimiero, Michela De Bellis, Jean-Alain Fehrentz, Séverine Denoyelle, Elena Bresciani, Antonio Torsello, Antonietta Mele, Antonella Liantonio, Ornella Cappellari, Annamaria De Luca

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  • ·Bespoke doxorubicin-loaded gold nanoparticles for ultrasound-guided cancer cell killing

    Article :118777

    Federica Foglietta, Agnese Fragassi, Cristiano Pesce, Francisco Andres Soto Arratia, Alberto Mangia, Maurizio Giustetto, Gianni Durando, Gian Matteo Morano, Paolo Caliceti, Andrea Grandoni, Roberto Canaparo, Loredana Serpe, Stefano Salmaso

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  • ·Apremilast attenuates hepatic steatosis and metabolic dysfunction in a murine model of MASLD: Implications for patients with Psoriatic disease

    Article :118757

    Miriam Ruiz-Ponce, Sergio Rodriguez-Cuenca, Jesus Eduardo Martin-Salazar, Carlos Pérez-Sánchez, Julio M. Martínez-Moreno, Adrián Llamas-Urbano, Mark Campbell, Laura Romero-Zurita, Maria Dolores López-Montilla, Laura Cuesta-López, Antonio Manuel Barranco, Pedro Ortiz-Buitrago, Chary López-Pedrera, Alejandro Escudero-Contreras, Eduardo Collantes-Estevez, Clementina López-Medina, Antonio Vidal-Puig, Iván Arias-de la Rosa, Nuria Barbarroja

    Résumé Résumé Plan Plan   
  • ·Bixin prevents tubulointerstitial fibrosis in hyperuricemic nephropathy via promoting PPARγ-NLRP3 interaction

    Article :118745

    Yun Cao, Jie Deng, Mingying Lin, Yan Su, Ying Zhang, Maowei Xie, Daofa Zhang, Hui Han, Yanni Wang, Xiangdong Yang, Yizhi Chen, Jiali Wei

    Résumé Résumé Plan Plan   
  • ·TTP enhances the sensitivity of KRAS^G12C-mutated lung cancer cells to KRAS^G12C inhibitors by downregulating SLC7A11 and promoting ferroptosis

    Article :118772

    Ki Ra Park, Minh-Xuan Le, Ok Joo Sul, JiHeung Jeon, Min Sung Kwon, Haebin Lee, Seung Won Ra, Hyuk Nam Kwon, Wha Ja Cho, Jeong Woo Park

    Résumé Résumé Plan Plan   
  • ·Neuroprotective effects of polyphenol-rich extracts obtained from agricultural by-products in an induced cognitive decline model of zebrafish larvae and in human neurons

    Article :118776

    Ángela Castillo-Moral, Job Tchoumtchoua, Kevin Leonard, Josep M. Del Bas, Nàdia Ortega, Xavier Escoté, Joan Teichenné

    Résumé Résumé Plan Plan   
  • ·Docking and database screening identify manidipine as a potential modulator of matrix metalloproteinase-7 in chronic kidney disease

    Article :118748

    Chia-Te Liao, Yen-Chung Lin, Hung-Jin Huang, Wen-Chih Liu, Wei-Chih Kan, Hui-Wen Chiu

    Résumé Résumé Plan Plan   
  • ·Effects of isoflurane on tetrodotoxin-resistant Na⁺ channels in rat nociceptive sensory neurons: Roles of concentration and extracellular pH

    Article :118746

    Michiko Nakamura, Il-Sung Jang

    Résumé Résumé Plan Plan   
  • ·Increases in brain catecholamine levels counteract memory deficits and reduces Aβ deposition in 5XFAD male mice

    Article :118764

    Eunbi Cho, Jee Hyun Yi, Se Jin Jeon, Dae Hyun Kim, Huiyoung Kwon, Jieun Jeon, Kyoung Ja Kwon, Dong Pyo Jang, Minho Moon, Chan Young Shin, Dong Hyun Kim

    Résumé Résumé Plan Plan  
  • ·Combination of CBD with minor cannabinoid CBDV suppresses CXCR4 via CB2 receptor and alleviates colitis in mice

    Article :118768

    Anat Gelfand, Elazar Besser, Shiri Procaccia, Jonathan Cohen, Miryam Steinberg, Oded Kleifeld, David Meiri

    Résumé Résumé Plan Plan   
  • ·Vutiglabridin ameliorates obesity by directly reducing fat mass through AMPK/lipophagy activation in adipocytes

    Article :118759

    Hyeong Min Lee, Jae Ho Lee, Sang Hyo Kim, Kamindu Gayashan Marakkalage, Jihyeon Hur, Hyung Soon Park, Kwang Pyo Kim, Gu-Choul Shin, Sang-Ku Yoo

    Résumé Résumé Plan Plan   
  • ·Mitochondrial cargo quality determines the paracrine effects of extracellular vesicles derived from vascular endothelial cells

    Article :118751

    Zahid A. Manzar, Lucas J. Davis, Karl F. Swanson, Erik Muñoz, Hazel H. Szeto, Hans Minderman, B. Rita Alevriadou

    Résumé Résumé Plan Plan  
  • ·Endogenous gut microbiome and implanted intranasal E. coli-Nissle modulate cancer tissues metabolism in 4T1 syngeneic tumor bearing mice

    Article :118750

    Alexander Cecil, Ivaylo Gentschev, Cornelia Prehn, Stefanie Hauck, Michael Witting, Ivan Petrov, Mingyu Ye, Eman M. Othman, Aladar A. Szalay

    Résumé Résumé Plan Plan   
  • ·Epidural pre-formed long-acting implants as a novel and challenging approach for brain drug delivery

    Article :118769

    O Hyun Lee, Ji Hee Kang, Da Hee Oh, Young Tag Ko

    Résumé Résumé Plan Plan   
  • ·Novel targets for treating cancer and inflammatory disorders: A disintegrin-metalloprotease-10 and cyclooxygenase-2 feedback loop modulated by Aconitum heterophyllum leaf biomarkers with computational biology

    Article :118752

    Muhammad Ilyas, Anwar Ali Shad, Aiman Orakzai, Zafar Ali Shah, Badriyah S. Alotaibi, Marwah Suliman Maashi

    Résumé Résumé Plan Plan   
  • ·Fangchinoline suppresses melanoma metastasis by inducing senescence of circulating tumor cells

    Article :118770

    Junhao Chen, Jianyang Hu, Jiapeng He, Binyu Zhang, Haoyuan Tan, Qiqi Wang, Hailiang Hu, Suling Xu, Chris Soon Heng Tan, Jianglin Zhang, Xin Hong

    Résumé Résumé Plan Plan   
  • ·Anti-cathepsin D antibody-drug conjugates for the targeted delivery of monomethyl auristatin F and E elicit potent anticancer activity in breast cancer

    Article :118775

    Diane Nishimwe, Gaëlle Guillon, Aude Mallavialle, Camille Martin, Steve Huvelle, Lindsay B. Alcaraz, Andréa Romero, Cynthia Garapon, Véronique Garambois, Hanane Mansouri, Florence Boissière-Michot, Ilona Berestjuk, Marta Jarlier, Andrei Turtoi, Caroline Denevault-Sabourin, Pascal Roger, Séverine Guiu, Thierry Chardès, Nicolas Joubert, Valérie Laurent-Matha, Emmanuelle Liaudet-Coopman

    Résumé Résumé Plan Plan   
  • ·Revisiting soluble guanylate cyclase pharmacology: Additive potential of stimulators and activators

    Article :118762

    Alexandra Petraina, Mahmoud H. Elbatreek, Christopher T. Neullens, Theodora Saridaki, Vu Thao-vi Dao, Rebecca D. Szepanowski, Emil Martin, Wolfgang Sippl, Ana I. Casas, Harald H.H.W. Schmidt

    Résumé Résumé Plan Plan   
  • ·Self-propelled biohybrids co-deliver oxaliplatin and glucose oxidase for multimodal treatment of colon cancer

    Article :118812

    Hongjun Deng, Shilin Xu, Kang Xiong, Qian Wen, Yue Li, Jingrong Huang, Yun Lu, Kewei Xiang, Tao Li, Linsong Zhang, Shaozhi Fu

    Résumé Résumé Plan Plan   
  • ·Anti-prion drugs reduce endoplasmic reticulum stress and protect human dopaminergic neurons from death

    Article :118758

    Lucile Gentile, Adeel Nasir, Loane Simon, Anaëlle Timoner, Anaïs Péron, Maha Sinane, Pierre Conan, Alexis Boulinguiez, Anna-Katharina Ückert, Marcel Leist, Capucine Trollet, Gaëlle Friocourt, Frédéric Bihel, Cécile Voisset

    Résumé Résumé Plan Plan   
  • ·Development of recombinant Mesozumab-CPTin that dual-targets mesothelin and CP2c for anticancer therapy

    Article :118799

    Boram Kim, Kyu Tae Byun, Junmin Cho, Inbeom Lee, DongSun Park, Tae-Bong Kang, Hyung-Sik Won, So Yeong Cheon, Chan Gil Kim

    Résumé Résumé Plan Plan   
  • ·Next-generation CAR T cells targeting integrin αvβ6 and PD-L1 to enhance immunotherapy for cholangiocarcinoma

    Article :118806

    Chalermchai Somboonpatarakun, Nattaporn Phanthaphol, Kwanpirom Suwanchiwasiri, Boonyanuch Ramwarungkura, Pa-thai Yenchitsomanus, Mutita Junking

    Résumé Résumé Plan Plan   
  • ·Antagonizing epigenetically controlled PAF/PAF-R pathway improves liver function during experimental cirrhosis

    Article :118804

    Enrique Ángel-Gomis, Esther Caparrós, Isabel Gómez-Hurtado, Sebastián Martínez-López, Ani Gasparyan, Anabel Fernández-Iglesias, Benedikt Simbrunner, Paula Boix, Jordi Gracia-Sancho, Oriol Juanola, Rubén Francés

    Résumé Résumé Plan Plan   
  • ·Apoptosis-promoting autophagy mediates anti-migratory effects of unsymmetrical bisacridines in pancreatic cancer cells

    Article :118786

    Agnieszka Kurdyn, Bożena Pezała, Ewa Paluszkiewicz, Ewa Augustin

    Résumé Résumé Plan Plan   
  • ·Cannabidiol modulates brain molecular alterations, gut microbiota dysbiosis and alcohol self-administration in a mouse model of fetal alcohol spectrum disorder

    Article :118791

    F. Navarrete, R. Cabrera-Rubio, A. Gasparyan, R. Aarnio, F. López-Picón, S. Helin, J. Rajander, M.C. Collado, J. Manzanares

    Résumé Résumé Plan Plan  
  • ·siRNA-based therapeutic candidate targeting PRDM2 for inhibition of lung cancer progression

    Article :118807

    Sanjay Kumar, Md Zubbair Malik, Maya Chaturvedi, Mohit Mishra, Marzia Di Donato, Amelia Casamassimi, Ciro Abbondanza, Patrizia Gazzerro, Chuong Nguyen, Nicole N. Nuñez, Somdutta Sen, Brad Niles, Rupesh Chaturvedi

    Résumé Résumé Plan Plan   
  • ·KN21, a direct AMPK activator, alleviates hepatic steatosis and fibrosis by modulating long-chain TAG and pyrimidine metabolism in a MASH mouse model

    Article :118798

    Jueun Lee, Seojeong Kim, Yeajin Ju, Minjung Seo, Hyeri Kim, Jae-Ho Shin, Younghwa Na, Youngjoo Kwon, Geum-Sook Hwang

    Résumé Résumé Plan Plan   
  • ·Patient-derived neuroblastoma models are sensitive to nucleolin-recognizing liposomal drugs

    Article :118817

    Veronica Bensa, Hugo Lopes-Cardoso, Eleonora Ciampi, Anastasiya Voronovska, Giovanna Bianchi, João Manuel Soares-Gonçalves, Martina Morini, Martina Ardito, Gaia Marino, Beatrice Gualco, Roberta Musso, Chiara Concetti, Katia Mazzocco, Gabriele Gaggero, Valerio Gaetano Vellone, Vito Alessandro Lasorsa, Mario Capasso, Michele Cilli, Loredana Amoroso, Martina Fragola, Massimo Conte, Mirco Ponzoni, Chiara Brignole, João Nuno Moreira, Fabio Pastorino

    Résumé Résumé Plan Plan   
  • ·Natural product screening reveals nanomolar Musashi2 inhibitor reducing forgetting in Caenorhabditis elegans

    Article :118811

    Tamara Balsiger, Robert Hagmann, Kim-Dung Huynh, Pablo Solis, Matthias Hamburger, Andreas Papassotiropoulos, Robin Teufel, Eliane Garo, Attila Stetak

    Résumé Résumé Plan Plan   
  • ·Hyaluronic acid-functionalized liposomes for CD44-targeted anticancer therapy: In Vitro induced cytotoxicity in HeLa cells

    Article :118783

    Marketa Kolarikova, Barbora Hosikova, Katerina Langova, Ales Benda, Dalibor Panek, Zuzana Cockova, Hanna Dilenko, Lukas Malina, Lucie Valkova, Hana Kolarova

    Résumé Résumé Plan Plan   
  • ·Targeting the polyol pathway in NSCLC: Trans-(±)-kusunokinin demonstrates anti-migratory and survival benefits in in vitro and in vivo models

    Article :118795

    Tanotnon Tanawattanasuntorn, Paradesi Naidu Gollavilli, Adriana Martinez Turtos, Mohammad Aarif Siddiqui, Vignesh Ramesh, Tienthong Thongpanchang, Khotchawan Bangpanwimon, Adisak Noonai, Paolo Ceppi, Potchanapond Graidist

    Résumé Résumé Plan Plan   
  • ·Calcium blockers protect against sensory epithelial damage and hearing loss in Cx26-cKO mice

    Article :118829

    Xue Bai, Bing Liao, Wen-Hui Hu, Mei-Qun Wang, Xu-Bo Chen, Yue-Hui Liu, Yu Sun, Kai Xu

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  • ·Polydopamine-coated gold nanoparticles promote cartilage regeneration and alleviate osteoarthritis in rats

    Article :118828

    Sujin Choi, Sung-Sahn Lee, Junwon Choi, Hyunjeong Yeo, Hannah Kim, Hyerin Yun, Soonchul Lee, Hyun-Ju An

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  • ·Systemic and skeletal muscle metabolic signatures associated with early insulin resistance in just-weaned non-obese Goto-Kakizaki diabetic rats

    Article :118826

    Thyerre Santana da Costa, João Guilherme de Moraes Pontes, Gonzalo García Delgado, Folorunsho Bright Omage, Giovanna de Oliveira Santana, Glayce Tavares Rodrigues, Maria Vitória Martins Scervino, Tania Cristina Pithon-Curi, Vinicius Cruzat, Roberto Barbosa Bazotte, Sandro Massao Hirabara, Renata Gorjao, Rui Curi, Ljubica Tasic

    Résumé Résumé Plan Plan   
  • ·Dual targeting of BCMA and B7-H3 with CAR T cells and bispecific protein engagers enhances anti-myeloma activity

    Article :118820

    Naeramit Sontayananon, Pornpimon Yuti, Nunghathai Sawasdee, Seiji Okada, Mutita Junking, Jatuporn Sujjitjoon, Pa-Thai Yenchitsomanus

    Résumé Résumé Plan Plan   
  • ·Quantitative and qualitative comparison of mRNA loading techniques into extracellular vesicles

    Article :118813

    Mònica Guarro, Stijn van Veen, Salvador Borrós, Lorenzo Albertazzi, Martí Lecina, Cristina Fornaguera

    Résumé Résumé Plan Plan   
  • ·A novel dual CDC25-HDAC inhibitor suppresses glioblastoma progression via chromosomal passenger complex disruption

    Article :118816

    Richa Upadhyay, Bidyadhar Sethy, Wen-Bin Yang, Ming-Hsiao Wu, Ke-Chi Liou, An-Chih Wu, Iin Narwanti, Kunal Nepali, Jing-Ping Liou, Jian-Ying Chuang

    Résumé Résumé Plan Plan   
  • ·Oxytocin treatment reduces cancer cachexia in a pre-clinical model

    Article :118825

    Alexandra Sviercovich, Etsuko Watanabe, Estefania S. Fernandez, Alessandra Renzini, Chao Liu, Grace Xie, Jasmine Cao, Zhenlin Li, Onnik Agbulut, Marilia Seelaender, Jose Pinhata Otoch, Daniele De Meo, Gianluca Cera, Viviana Moresi, Francesca Palermo, Sergio Adamo, Michael J. Conboy, Irina M. Conboy, Dario Coletti

    Résumé Résumé Plan Plan   
  • ·An indole derivative of Ursolic acid, inhibits RANKL-induced osteoclast differentiation via modulating the Nrf2 and NFATc1/c-Fos axis: Targeting oxidative stress and osteoclastogenesis in managing rheumatoid arthritis

    Article :118801

    Rupali Choudhary, Jasha Momo H. Anal, Boobalan Gopu, Ramajayan Pandian, Bhavna Vij, Asha Bhagat, Gurleen Kour, Zabeer Ahmed

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  • ·Triterpenoid saponins from Ilex latifolia inhibit breast cancer growth by disrupting the SREBP1/FASN-mediated lipid metabolic pathway

    Article :118793

    Fangfang Wang, Mingjie Wang, Zihan Shi, Yongchen Wu, Cunqin Wang, Hongting Wang

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  • ·CB1 receptor activation and inhibition differentially modulate cognitive deficits and neuropathology in 3xTg-AD mice

    Article :118818

    Minsook Ye, Jin Su Kim, Insop Shim

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  • ·Differential adipose tissue remodeling and metabolic effects of dolutegravir and bictegravir: implications for HIV therapy

    Article :118831

    Laura Gisbert-Ferrándiz, Patricia García-Martínez, Juan V. Esplugues, Ángeles Álvarez-Ribelles, Ana Blas-García

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  • ·Inhibition of GABA metabolism by β-lactam antibiotics affects encystation in Acanthamoeba

    Article :118841

    Chih-Ming Tsai, Yao-Tsung Chang, Yu-Jen Wang, Chun-Hsien Chen, Chuan-Yi Wang, Jian-Ming Huang

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  • ·Dihydrotricetin from Euonymus hamiltonianus ameliorates neuroinflammation and exhibits neuroprotective effect in LPS-induced microglia

    Article :118810

    Tianqi Huang, Jae Sik Yu, Gyo Chang Keum, Hyun Ok Yang

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  • ·Cyclooxygenase-2 inhibition improves hypercholesterolemia-induced cardiac dysfunction

    Article :118836

    Bernadett Kiss, Regina N. Nagy, Gábor B. Brenner, Barnabás Váradi, Dóra Bihary, Bence Ágg, András Makkos, Csenger Kovácsházi, Nabil V. Sayour, Tamás G. Gergely, Zoltán Husti, István Baczkó, Dóra Reé, Ágota Apáti, Mihály Ruppert, Tamás Radovits, Béla Merkely, Paola Poggi, Alexandros Chatgilialoglu, Zoltán V. Varga, Zoltán Giricz, Péter Ferdinandy, Anikó Görbe

    Résumé Résumé Plan Plan   
  • ·A new biocompatible amino-Gd-metallofullerenol (Amino-Gd-FulOH) nanoplatform as a potential MRI contrast agent and its effect on macrophages

    Article :118842

    Marta Halasa, Beata Brzozowska, Malgorzata Kloc, Christof Karmonik, Maria Andrea Giselle Altenbaugh, Rafik Mark Ghobrial, Piotr Piotrowski, Grzegorz Litwinienko, Jacek Grebowski

    Résumé Résumé Plan Plan   
  • ·Ardisiaoside A, a new triterpenoid glycoside from Ardisia gigantifolia, induces cell senescence and targets cancer stem cells in gastric cancer

    Article :118839

    Van Khang Pham, Thi Thanh Huong Le, Nguyet Mai Hua, Son Hiep Pham, Van Hung Hoang, Thi Kieu Oanh Nguyen, Phu Hung Nguyen

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  • ·Dapagliflozin enhances hemodynamic and metabolic recovery following cardioplegic arrest in the isolated working mouse heart

    Article :118771

    Christopher Dostal, Johanna Reiner, Daniel Spona, Laurenz Wolner, Patrick M. Pilz, Lukas Weber, Gülsüm Yilmaz, Anna Stampfer, Martina Godel, Giulia Guerra, Alessandra Ghigo, Barbara Kapeller, Chiara Riganti, Ana Isabel Antunes Goncalves, Seth Hallström, Attila Kiss, Bruno K. Podesser

    Résumé Résumé Plan Plan   
  • ·Laser-activated NGQDs boost the therapeutic response of 5-FU in breast cancer cells

    Article :118794

    Seyedeh Zohreh Azarshin, Masoud Mozaffari, Jaber Zafari, Mehrdad Behmanesh, Esmaiel Saievar-Iranizad

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  • ·Indoxyl sulfate promoted glutamine metabolism and cell proliferation in urothelial carcinoma involving Runx2

    Article :118865

    Jian-Ri Li, Tung-Min Yu, Yen-Chuan Ou, Chih-Cheng Wu, Shih-Yi Lin, Ya-Yu Wang, Jiaan-Der Wang, Su-Lan Liao, Wen-Ying Chen, Yu-Hsiang Kuan, Chun-Jung Chen

    Résumé Résumé Plan Plan  
  • ·Synergistic antiproliferative and pro-apoptotic activity of dacarbazine combined with 2-aminoethyl dihydrogen phosphate in melanoma cells

    Article :118866

    Thalles Anthony Duarte de Oliveira, Gustavo Henrique Doná Rodrigues Almeida, Ranya Sthephanie Nascimento Ribeiro, Rosa Andrea Nogueira Laiso, Monique Gonçalves Alves, Yasmim Emilly Moreira Sousa, Ícaro Gabriel Teles Pacheco de Matos, Daniel da Conceição Rabelo, Rose Eli Grassi Rici, Solange Castro Afeche, Durvanei Augusto Maria

    Résumé Résumé Plan Plan  
  • ·Androgen receptor blockade and its effect on PSMA-localization in prostate cancer: Implications for radioligand therapy

    Article :118849

    Flavien Devaux, Kareem Beltagi, Thomas Frank Ermler, Sven Gerlach, Anna Herrmann, Jennifer Kranz, Radu Alexa, Agnieszka Morgenroth, Andreas Theodor Josef Vogg, Laura Schäfer, Najaf Mammadbayli, Matthias Saar, Marco Hoffmann

    Résumé Résumé Plan Plan  
  • ·Demonstration of SLU7 as a new cancer target

    Article :118854

    Carla Rojo, Aaron Otero, Maria Elizalde, Maria Azkona, Roberto Barbero, Maria U. Latasa, Iker Uriarte, Alvaro Gutierrez-Uzquiza, Diego Alignani, Laura Guembe, Amaia Lujambio, Fernando Pastor, Maite G. Fernández-Barrena, Matias A. Ávila, Maria Arechederra, Carmen Berasain

    Résumé Résumé Plan Plan   
  • ·β-glucan-loaded nano-niosomes ameliorate spatial and associative memory impairment in a D-galactose-induced aging rat model via modulation of microglial pyroptosis and autophagy

    Article :118834

    Fatemeh Rahmati-Dehkordi, Elham Zahedi, Soheila Adeli, Hamidreza Sahrayi, Seyed Morteza Karimian

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  • ·As48, a first-in-class dual-function TREM2 modulator: Receptor activation and shedding inhibition

    Article :118862

    Sungwoo Cho, Farida El Gaamouch, Saurabh Upadhyay, Hossam Nada, Katarzyna Kuncewicz, Moustafa T. Gabr

    Résumé Résumé Plan Plan   
  • ·Enhanced neurotoxic effects following co-administration of methamphetamine and ethanol in rats: Insights from integrated analysis of behavior, pharmacokinetics, and metabolomics

    Article :118856

    Mingyu Kim, Sang-Hoon Song, Suji Kim, Ye Jin Jung, Seung Jin Yoo, Jung Hoon Jung, Sooyeun Lee

    Résumé Résumé Plan Plan   
  • ·Niosomal co-delivery of metformin and telaglenastat: A targeted nanotherapeutic strategy for breast cancer treatment and metastasis suppression in 2D and 3D models

    Article :118843

    Ahlam Zaid Alkilani, Haneen A. Basheer, Maram A. Alhusban, Walhan Alshaer

    Résumé Résumé Plan Plan  
  • ·Peptide-assisted lipofection enables efficient non-viral delivery of large CRISPR/Cas9 constructs for genome editing applications

    Article :118838

    Yeong Chae Ryu, Gang Bao, Byeong Hee Hwang

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  • ·A comparative study of idarubicin and doxorubicin in a chemically-induced in vivo mouse model for hepatocellular carcinoma

    Article :118859

    Ada Lerma-Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx

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  • ·Synergistic effects of fucoidan from Undaria pinnatifida and grouper peptides on glucocorticoid-induced muscle atrophy via protein turnover modulation

    Article :118851

    Huey-Jine Chai, Tsung-Kai Yi, Jerrell Felim, Ming-Chieh Tu, Zwe-Ling Kong

    Résumé Résumé Plan Plan  
  • ·Temporal and demographic patterns of peripheral nerve proteomes in preclinical neuropathic pain

    Article :118855

    Sabrina Grundtner, Feng Xian, Daniel Malzl, Tina Radits, Allison Marie Barry, Julia Regina Sondermann, Jörg Menche, David Gómez-Varela, Manuela Schmidt

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  • ·Balancing cell cycle arrest and immune activation: A synergistic window for idasanutlin and anti-PD-1 therapy in a syngeneic mouse model

    Article :118868

    Aneta Nieznanska, Malgorzata Statkiewicz, Zuzanna Sandowska-Markiewicz, Katarzyna Unrug-Bielawska, Alicja Majewska, Justyna Kocik-Krol, Marcin Czepiel, Adrianna Galuszka-Bulaga, Michal Mikula, Jerzy Ostrowski, Tad A. Holak, Lukasz Skalniak

    Résumé Résumé Plan Plan   
  • ·Rapid transcellular hepatic copper depletion by ARBM-101 rescues severe liver damage in Wilson disease rodents

    Article :118867

    Jonas Engler, Eun-Jung Kim, Dasol Kim, Noreene M. Shibata, Emilie Munk Lynderup, Mikkel H. Vendelbo, Banu Akdogan, Judith Sailer, Adriana Fontes, Carola Eberhagen, Tamara Rieder, Quirin Reinold, Hongjae Lee, Dongsik Park, Chunwon Jung, Weonbin Im, Susanne I. Wudy, Karin Kleigrewe, Stefan Engelhardt, Alan A. DiSpirito, Thomas Damgaard Sandahl, Valentina Medici, So-Young Eun, Hans Zischka

    Résumé Résumé Plan Plan   
  • ·In vitro assessment of pirfenidone anti-fibrotic properties in a humanized 3D bioprinted kidney tubulointerstitium model

    Article :118880

    Gabriele Addario, Alessandro Bortolin, Lorenzo Moroni, Carlos Mota

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  • ·Metabolic profiles of the human blood-brain barrier cells treated by TNF-alpha and oxysterols

    Article :118853

    Cindy Nguyen, Kenneth C.P. Cheung, Xiaoli Chen, Julien Saint-Pol, Fumitaka Shimizu, Takashi Kanda, Caroline Pot, Maxime Culot, Kannie W.Y. Chan, Wang Lu, Aiping Lyu, Wei Jia, Fabien Gosselet

    Résumé Résumé Plan Plan   
  • ·Protective effect of a novel metal-phenolic network composite against ultraviolet-induced skin damage by modulating MAPK/AP-1/NF-κB signaling pathways and attenuating oxidative stress in human keratinocytes

    Article :118874

    Mi Hee Shin, Youngji Kwon, Seunghee Lee, Hye-been Kim, Hyeyoun Kim, Sugyeong Jeong, SeokKyun Yun, Chun Ho Park, Ohsang Kwon

    Résumé Résumé Plan Plan   
  • ·Enhancing colorectal cancer treatment with a triple therapy approach involving 5-fluorouracil, thymoquinone, Polygonum minus

    Article :118729

    Kshidan Marim Abdullah Salem, Ibrahim Malami, Kim Wei Chan, Md Zuki Abu Bakar, Noorjahan Banu Mohammed Alitheen, Mohammed Alsubbi, Hamidu Ahmed, Ahmad Faizal Abdull Razis, Norsharina Ismail

    Résumé Résumé Plan Plan  
  • ·Role of anthocyanins in protecting chondrocytes from high glucose damage through SIRT-1 and autophagy in diabetic osteoarthritis

    Article :118870

    Benjawan Wudtiwai, Pattaralawan Sittiju, Aitthiphon Chongchai, Sasimol Udomruk, Apichaya Rujiphan, Prachya Kongtawelert, Thanyaluck Phitak, Peraphan Pothacharoen

    Résumé Résumé Plan Plan   
  • ·ASPP-092, a Curcuma comosa diarylheptanoid, inhibits the adipogenic differentiation of human bone marrow-derived mesenchymal stem cells via activation of TGF-β/SMAD2/3 signaling

    Article :118884

    Nareerat Sutjarit, Klodthida Yanukun, Kanit Bhukhai, Nithi Asavapanumas, Sarun Rangketkarn, Umnuaychoke Thongsa-ad, Waraluck Chaichompoo, Apichart Suksamrarn, Sunhapas Soodvilai, Duangrat Tantikanlayaporn

    Résumé Résumé Plan Plan   
  • ·Adipocyte-derived apelin protects against radiation-induced enteropathy through Wnt/β-catenin–mediated intestinal regeneration

    Article :118879

    Jung Moon Kim, Ki-Chun Yoo, Jeong-Won Kim, Seung Bum Lee, Younghoon Son, Hae-June Lee, Sang-Pil Choi, Han Byul Kim, Seokjin Lee, Sang Sik Cho, Hwi-Yool Kim, Hyosun Jang

    Résumé Résumé Plan Plan   
  • ·ENT1 inhibition enhances weight control and metabolic health in diet-induced obesity

    Article :118848

    Lucas Chaible, Julie Preillon, Charlotte Philippart, Alizée Canevat, Laura Saerens, Dimitri Kondratow, Michael Deligny, Alexis Goffaux, Anne-Catherine Michaux, Marie-Claire Letellier, Nicolas Rosewick, David Carbonez, João Marchante, Francesco Strozzi, Erica Houthuys, Reece Marillier, Yvonne McGrath, Steven Van der Plas, Alexander Pfeifer, Julie Chesné

    Résumé Résumé Plan Plan   
  • ·Targeted radioiodine therapy of ovarian cancer via the sodium/iodide symporter (NIS)

    Article :118873

    Lidia Mirela Mielu, Lucía Rodal-Bravo, Cristina Diego-Hernández, Sarai Varona, Dánae Fajardo-Delgado, Rafael Hortiguela, Monica Torres-Ruiz, Isabel Cuesta, Pilar Pallares, Pilar Santisteban, Custodia García-Jiménez, Pilar Martín-Duque, Antonio De la Vieja

    Résumé Résumé Plan Plan   
  • ·Leveraging multi-organ models for drug combination therapy safety

    Article :118847

    Valentin Mieville, Jakub Gubala, Seungsu Han, Marie Ota, Mireia Andreu-Carbó, Filippo Molica, Daniel Benamran, Brenda R. Kwak, Massimo Valerio, Patrycja Nowak-Sliwinska

    Résumé Résumé Plan Plan   
  • ·Bufalin alleviates myocardial ischemia-reperfusion injury by targeting PTGR2 to regulate NF-κB mediated inflammation

    Article :118895

    Jinlin Hu, Teng Ge, Jie Lin, Jingyu Bo, Liangbing Yang, Bo Ning, Miao Zhang, Kunyang He, Chaojie Wang, Guanmou Li, Rongjun Zou, Xiaoping Fan

    Résumé Résumé Plan Plan   
  • ·Curcumin impacts on cisplatin sensitivity determining apoptotic boost in mesothelioma

    Article :118827

    Miriam Piccioni, Emilia Caputo, Rossana Cuciniello, Francesco Di Meo, Anna Valentino, Gianluigi Petillo, Elena Rinaldi, Orsolina Petillo, Alfonso Baldi, Stefania Filosa, Paolo Bergamo, Stefania Crispi

    Résumé Résumé Plan Plan   
  • ·Ziyuglycoside II potentiates the antibacterial activity of tetracycline against multidrug-resistant Staphylococcus aureus

    Article :118844

    Shuo Wei, Yuefeng Wu, Haihong Hao, Yitao Li, Huili Lu, Adil Mohammad, Ali Ahmad, Xingmei Deng, Tianyi Zhao, Jia Guo, Zhen Wang, Hongsu He, Zhihua Sun, Hui Zhang

    Résumé Résumé Plan Plan  
  • ·Cannabidiol promotes fine-tuning of natural killer and monocytic cells subsets as well as cytokine storm during chikungunya virus exposure in vitro: Insights for putative therapeutic interventions

    Article :118900

    Erik Vinicius de Sousa Reis, Ágata Lopes-Ribeiro, Thaís de Fátima Silva Moraes, Geovane Marques-Ferreira, Laura Cardoso Corrêa-Dias, Marília Bueno da Silva Menegatto, Caio Wilker-Teixeira, Adriano de Paula Sabino, Jordana Grazziela Alves Coelho-dos-Reis

    Résumé Résumé Plan Plan   
  • ·In silico virtual screening of natural small molecules for dual inhibition of Aβ and tau aggregation in Alzheimer's disease

    Article :118876

    Sujin Kim, Vijay Kumar, Soo Jung Shin, Yunkwon Nam, Yong Ho Park, Sinae Jang, Jun Young Park, Dong Hyun Kim, Minho Moon

    Résumé Résumé Plan Plan   

• Short Communications

  • ·Mitochondrial stress bridge: Could muscle-derived extracellular vesicles be the missing link between sarcopenia, insulin resistance, and chemotherapy-induced cardiotoxicity?

    Article :118814

    Okechukwu Paul-Chima Ugwu, Fabian C. Ogenyi, Chinyere Nneoma Ugwu, Mariam Basajja, Michael Ben Okon

    Résumé Résumé Plan Plan  
  • ·RETRACTED: Therapeutic prospects of modulating TLR4/MAPK/ROS signalling in obesity-associated neuroinflammation

    Article :118805

    Drashti Sharma, Ram Narayanan Ravi, Amar Daud Iskandar Abdullah, Vetriselvan Subramaniyan

    Résumé Résumé
  • ·Integrated systems vaccinology reveals distinct metabolic responses to SARS-CoV-2 infection and DNA-based vaccines in ferrets

    Article :118858

    Gustaf Ahlén, Anoop Ambikan, Flora Mikaeloff, Sefanit Rezene, Jingyi Yan, Negin Nikouyan, Chandrashekar Bangalore Revanna, Sofia Appelberg, Ali Mirazimi, Matti Sällberg, Ujjwal Neogi, Soham Gupta

    Résumé Résumé Plan Plan   

• Letters to the Editor

  • ·MSC-delivered CXCL10 for solid tumors: Navigating the translational hurdles from precept to clinic

    Article :118735

    Dujiang Yang, Guoyou Wang

    Résumé Résumé Plan Plan  

• Corrigendum

  • ·Corrigendum to “Areca catechu L. ameliorates chronic unpredictable mild stress-induced depression behavior in rats by the promotion of the BDNF signaling pathway” [Biomed. Pharmacother. 164 (2023), 114459]

    Article :118634

    Caihong Yao, Yiwen Zhang, Xinran Sun, Haiyue Pei, Shanshan Wei, Mengdi Wang, Qi Chang, Xinmin Liu, Ning Jiang

     
  • ·Corrigendum to “MiR-130a exerts neuroprotective effects against ischemic stroke through PTEN/PI3K/AKT pathway” [Biomed. Pharmacother. 117 (2019) 109117]

    Article :118700

    Tingting Zheng, Yu Shi, Jun Zhang, Jiao Peng, Xue Zhang, Keke Chen, Yun Chen, Li Liu

     
  • ·Corrigendum to “Cardiac regeneration revisited: Enhanced cardiomyocyte differentiation and repair through composite microenvironments and small molecules” [Biomed. Pharmacother. 192 (2025) 118642]

    Article :118736

    Manizheh Azhdari, Shahram Rabbani, Nader Tanideh, Safieh Boroumand

    
  • ·Corrigendum to “The role of liquid-liquid phase separation in the disease pathogenesis and drug development” [Biomed. Pharmacother. 180 (2024) 117448]

    Article :118740

    Yingjie Zhang, Chengkang Jin, Xiaoling Xu, Junping Guo, Lijun Wang

    
  • ·Corrigendum to “Gene and drug-mediated SERCA2a activation restores cardiac function and metabolic balance in diabetic mice” [Biomed. Pharmacother. 192, November 2025, 118617]

    Article :118779

    Soojeong Kang, Abdul Majid, Nadjib Hammoudi, Djamel Lebeche

    
  • ·Corrigendum to “Apixaban kinetics could be influenced by sex, cytochrome P450 enzymes and SLC6A2 transporter” [Biomed. Pharmacother. 193 (December) (2025) 118732]

    Article :118780

    Eva González-Iglesias, Dolores Ochoa, Houwaida Abbes, Gonzalo Villapalos-García, Manuel Román, Sergio Luquero-Bueno, Samuel Martín-Vilchez, Jesús Novalbos, y Francisco Abad-Santos

    
  • ·Corrigendum to “Mechanical stress protects against chondrocyte pyroptosis through TGF-β1-mediated activation of Smad2/3 and inhibition of the NF-κB signaling pathway in an osteoarthritis model” [Biomed. Pharmacother., 2023 Mar:159:114216. doi: 10.1016/j.biopha.2023.114216. Epub 2023 Jan 11]

    Article :118787

    Yang Wang, Zhuangzhuang Jin, Shuangshuo Jia, Peng Shen, Yue Yang, Ying Huang

     
  • ·Corrigendum to “Undesirable ER stress induced by bavachin contributed to follicular atresia in zebrafish ovary” [Biomed. Pharmacother. 166 (2023) 115322]

    Article :118788

    Cong-Shu Huang, Hui-Fang Deng, Lei Zhou, Pan Shen, Yu-Hao Ni, Ning-Ning Wang, Gao-Fu Li, Lan-Xin Yue, Yong-Qiang Zhou, Wei Zhou, Yue Gao

     
  • ·Corrigendum to “In vitro screening of synbiotics based on a four-strain probiotic blend and their therapeutic potential for ulcerative colitis” [Biomed. Pharmacother., vol. 191 (2025) page 118521]

    Article :118789

    Jiahao Liao, Ying Guo, Zhuoya Guo, Xianqian Zhang, Xiaoqiong Li, Jian Kuang, Jianqiang Li, Xiangyu Bian, Weiwei Wang, Jinjun Li

    
  • ·Corrigendum to “FGF/FGFR inhibitors downmodulate c-Myc oncoprotein and hamper the growth of adrenocortical carcinoma” [Biomed. Pharmacother. 192 (2025) 118677]

    Article :118824

    Sara Taranto, Jessica Faletti, Mariangela Tamburello, Roberto Ronca, Giulia Garattini, Giorgia Gazzaroli, Marta Turati, Edoardo Rocca, Riccardo Castelli, Andrea Abate, Luca Mignani, Marta Laganà, Constanze Hantel, Sandra Sigala, Marco Presta, Arianna Giacomini

    
  • ·Corrigendum to “High potency of magnetic iron oxide nanoparticles covered by piroctone olamine against cystic echinococcosis” [Biomed. Pharmacother., 2023 (161) 114536]

    Article :118832

    Yosra Raziani, Koroush Cheraghipour, Mojtaba Shakibaie, Javad Ghasemian Yadegari, Hossein Mahmoudvand

    
  • ·Corrigendum to “Bicyclol ameliorates nonalcoholic fatty liver disease in mice via inhibiting MAPKs and NF-κB signaling pathways” [Biomed. Pharmacother. 141 (2021) 1–12/111874]

    Article :118888

    Weixin Zhao, Yixiao Yan, Zhongxiang Xiao, Meihong Wang, Mingjiang Xu, Zhe Wang, Yi Wang, Zaishou Zhuang, Daona Yang, Gaozhi Chen, Guang Liang

     
  • ·Corrigendum to “Inhibition of p38 and ERK1/2 pathways by Sparstolonin B suppresses inffammation-induced melanoma metastasis” [Biomed. Pharmacother. 98 (2018) 382–389]

    Article :118890

    Ya-Min Tang, Qing-Yun Cao, Xing-Yu Guo, Shui-Hua Dong, Jin-Ao Duan, Qi-Nan Wu, Qiao-Li Liang

    

• Retractions

  • ·Retraction notice to “Long noncoding RNA OIP5-AS1 promotes the progression of oral squamous cell carcinoma via regulating miR-338-3p/NRP1 axis” [Biomed. Pharmacother. 118 (2019) 109259]

    Article :118821

    Minghe Li, Jun Ning, Zhihong Li, Qianyi Fei, Cong Zhao, Yue Ge, Lei Wang

    
  • ·Retraction notice to “INF2 regulates oxidative stress-induced apoptosis in epidermal HaCat cells by modulating the HIF1 signaling pathway” [Biomed. Pharmacother., 111 (2019) 151–161]

    Article :118822

    Zhixiong Chen, Chenyu Wang, Nanze Yu, Loubin Si, Lin Zhu, Ang Zeng, Zhifei Liu, Xiaojun Wang

    
  • ·Retraction notice to “Chaiqin chengqi decoction alleviates severe acute pancreatitis associated acute kidney injury by inhibiting endoplasmic reticulum stress and subsequent apoptosis” [Biomed. Pharmacother. 125 (2020) 110024]

    Article :118823

    Xuefei Yang, Xiaoxin Zhang, Ziqi Lin, Jia Guo, Xinmin Yang, Linbo Yao, Haoyang Wang, Ping Xue, Qing Xia

    
  • ·Retraction notice to “Long noncoding RNA CRNDE promotes non-small cell lung cancer progression via sponging microRNA-338–3p” [Biomed. Pharmacother. 110 (2019), 825–833]

    Article :118883

    Hongyu Jing, Huan Xia, Ming Qian, Xiaohong Lv

    
  • ·Editor Note to article entitled “TG2 promotes amyloid beta aggregates: Impact on ER-mitochondria crosstalk, calcium homeostasis and synaptic function in Alzheimer’s disease” [Biomed. Pharmacother., 162 (2023) 114596]

    Article :118781

    
  • ·Expression of concern: "Chaenomeles sinensis polysaccharide and its carboxymethylated derivative alleviate dextran sulfate sodium-induced ulcerative colitis via suppression of inflammation and oxidative stress” [Biomed. Pharmacother. 169 (2023) 115941]

    Article :118782